Alt Advances in Immunology

1. Auflage 2009
ISBN: 978-0-08-095102-7
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 300 Seiten

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future.
* Contributions from leading authorities and industry experts
* Informs and updates on all the latest developments in the field

Autoren/Hrsg.

Alt, Frederick W.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Immunology;4
3;Copyright Page;5
4;Contents;6
5;Contributors;8
6;Chapter 1: Antigen Presentation by CD1: Lipids, T Cells, and NKT Cells in Microbial Immunity;10
6.1;1. Introduction;12
6.2;2. The CD1 Antigen Presentation Pathway: Chemistry, Structure, and Cell Biology;12
6.3;3. Group I CD1: CD1a, b, and c Molecules and T Cells;37
6.4;4. Group II CD1: CD1d-Restricted T Cells: Activation, Function, and Role in Antimicrobial Immunity;44
6.5;5. Role of CD1d-Restricted NKT Cells in Specific Microbial Infections;58
6.6;6. Conclusions;77
6.7;Acknowledgments;79
6.8;References;79
7;Chapter 2: How the Immune System Achieves Self-Nonself Discrimination During Adaptive Immunity;104
7.1;1. Introduction;106
7.2;2. Is Peripheral Immune Regulation Necessary for Self-Nonself Discrimination?;108
7.3;3. Self-Nonself Discrimination Achieved During Thymic Negative Selection Determines How the Adaptive Immunity is Regulated...;118
7.4;4. The Impact of the Conceptual Framework of the "Avidity Model" on the Development and Control of Pathogenic Autoimm...;127
7.5;Acknowledgments;136
7.6;References;136
8;Chapter 3: Cellular and Molecular Mechanisms in Atopic Dermatitis;144
8.1;1. Introduction;145
8.2;2. Physiology and Immunology of Normal Skin;146
8.3;3. Clinical Aspects of AD;152
8.4;4. Epidemiology;160
8.5;5. Genetics;162
8.6;6. Pathophysiology of AD;167
8.7;7. Animal Models of AD;180
8.8;8. Treatment of AD;210
8.9;9. Conclusion;212
8.10;Acknowledgments;213
8.11;References;213
9;Chapter 4: Micromanagers of Immune Cell Fate and Function;236
9.1;1. Introduction;237
9.2;2. miRNA Biogenesis;237
9.3;3. miRNA Regulation of Gene Expression;238
9.4;4. miRNA Target Genes;239
9.5;5. miRNAs Regulate Hematopoietic Differentiation and Immune Function;240
9.6;6. miRNA Regulation of Lymphocyte Development and Function;243
9.7;7. miRNA Regulation of Inflammatory Responses;244
9.8;8. Viruses Harness the miRNA Machinery;244
9.9;9. Some Viral miRNAs Mimic Host miRNAs;246
9.10;10. Host miRNAs also Regulate Viral Replication;246
9.11;11. Prospects for Manipulating miRNA Function for Immunomodulatory Therapy;247
9.12;Acknowledgment;248
9.13;References;248
10;Chapter 5: Immune Pathways for Translating Viral Infection into Chronic Airway Disease1;254
10.1;1. Introduction;255
10.2;2. Background for the Model;258
10.3;3. cDC T Cell Immune Axis;260
10.4;4. NKT Cell-Macrophage Immune Axis;267
10.5;5. Summary;278
10.6;Acknowledgments;281
10.7;References;281
11;Subject Index;286
12;Contents of Recent Volumes;294
13;Color Plates;302