Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

Erscheinungsjahr 2026
ISBN: 978-0-443-36615-4
Verlag: Elsevier Science

Buch, Englisch, 450 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 450 g

Cutting-edge technology for plant metabolite profiling in drug discovery and quality control offers a comprehensive exploration of advanced methods in plant metabolomics and their integration with industrial applications across various sectors. The book delves into a range of methodologies, including metabolic engineering strategies, metabolite imaging techniques, nuclear magnetic resonance (NMR) for plant metabolite analysis, microfluidics for metabolite profiling, computational methods and bioinformatics tools. It also explores plant metabolomics for crop improvement, pharmaceutical development, archaeological examinations, cosmetic formulations and food quality, with case studies featured throughout the book to showcase real-world applications and scenarios. As the demand for natural products and plant-derived therapeutics continues to rise, there is a need for reliable and effective methods to identify, quantify, and optimize the bioactive compounds present in plants. This book provides a comprehensive guide to the latest advances in this field, while also delivering a multidisciplinary overview of the wide-ranging impact plant metabolites have across a variety of applications. Researchers working with plant metabolites across molecular and cellular biology, pharmaceutical science, biotechnology, biochemistry and plant science will benefit from this book. Additionally, it will be of interest to specialists working across relevant industries, such as pharmaceuticals, nutraceuticals, cosmetics and agriculture.

Autoren/Hrsg.

Ahirwar, Ramesh Kumar

Singh, Chandan

Bhatia, Anil

Yadav, Deepanker

Srivastava, Akhileshwar Kumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Botanik
• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)

Inhaltsverzeichnis

1. Introduction to plant metabolite profiling: Concepts and techniques
2. Metabolic engineering strategies for enhanced plant metabolite production
3. Mass spectrometry in plant metabolomics: Advances and applications
4. Nuclear magnetic resonance spectroscopy for plant metabolite analysis
5. High-performance liquid chromatography in plant metabolomics
6. Metabolite imaging techniques: From principles to applications
7. Isotope tracing and fluxomics in plant metabolism studies
8. Nuclear magnetic resonance (NMR) spectroscopy in plant metabolite analysis: Applications in drug discovery
9. Ambient ionization techniques for rapid metabolite profiling in plant-based drug development
10. Microfluidics for high-throughput plant metabolite profiling
11. Emerging trends in metabolite profiling using microfluidics and lab-on-a-chip technologies
12. Metabolomics in crop improvement: Breeding for bioactive compounds
13. Metabolite profiling of endophytic microorganisms for drug discovery
14. Quality control and standardization of herbal medicines
15. Enhancing herbal medicine quality control through advanced fingerprint analysis
16. Discovery of bioactive-chemical Q-markers for quality control of plant medicine
17. Integrative approaches of metabolomics and DNA barcoding for identifying combinatorial discriminatory quality markers
18. Combining strategy of metabolomics and transcriptomics to identify medicinal properties of plants
19. Advanced computational methods and machine learning for metabolite identification and quantification in plant-derived drugs
20. Integration of plant metabolomics with systems biology approaches
21. Data analysis and bioinformatics tools for plant metabolomics
22. Regulatory considerations in plant-derived drug development
23. A unified framework for the application of plant metabolomics advancement in industries
24. Implication of metabolomics signature in archaeological examinations
25. Environmental metabolomics: Monitoring plant responses to stressors

Über Autor(innen)

Yadav, Deepanker
Dr. Deepanker Yadav is currently working as an Assistant Professor in the Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, India. He has more than ten years of experience in Plant Molecular Biology research. He received his master's degree from Banaras Hindu University and completed his PhD from the University of Hyderabad, India. He was also a visiting scholar at the University of Muenster Germany during his doctorate tenure. He conducted postdoctoral research at the Institute of plant science at Volcani centre, Agricultural Research Organization, Israel. He has been awarded various fellowships and grants. He has published several research papers and is a reviewer of several international journals.

Bhatia, Anil
Dr. Anil Bhatia is an accomplished researcher with a deep technical and analytical knowledge base in metabolomics, particularly in the realm of small molecule analysis and lipidomics. Currently serving as a Specialist III at the Metabolomics Core Facility, Institute for Integrative Genome Biology at the University of California, Riverside, Dr. Bhatia brings extensive expertise in developing and optimizing advanced methodologies for metabolomic studies. His work involves the use of sophisticated analytical platforms such as liquid chromatography-mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR) spectroscopy. He is adept at handling complex instrumentation, including time-of-flight (TOF) and triple quadrupole mass spectrometers, as well as ion mobility spectrometry systems, which are crucial for both targeted and untargeted metabolomics.

Srivastava, Akhileshwar Kumar
Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) at CSIR-Central Food Technological Research Institute, Mysore, India. In his 11 years of research, he has published more than 18 research articles in reputed international journals, along with 4 books and 11 book chapters. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology associated with targeting virulent factors of diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, USA, on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in the Indian Science Congress and the Agriculture, Nutrition and Health Academy, UK.

Ahirwar, Ramesh Kumar
Dr. Ramesh Kumar Ahirwar, a trained ethnobotanist, holds a PhD from Awadhesh Pratap Singh University, Rewa. Currently, he serves as an Assistant Professor in the Department of Botany at Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India, since December 2019. Dr. Ahirwar has over 12 years of extensive experience in ethnobotany, both as a researcher and faculty member, and he has authored more than 64 research papers, many of which have been published in prestigious Elsevier journals such as the Journal of Ethnopharmacology, South African Journal of Botany, and Advances in Traditional Medicine. Additionally, he has contributed four book chapters to edited volumes in reputable publications and authored three books on various aspects of ethnobotany. He has been awarded many projects by various funding agencies. He serves as a reviewer for various journals published by Elsevier and Springer Nature.

Singh, Chandan
Dr. Chandan Singh is an Assistant Professor at Banaras Hindu University, India, and a leading expert in Biological NMR Spectroscopy and Metabolomics, with a focus on membrane proteins. He has published 31 research articles and participated in postdoctoral assignments at Sanford Burnham Prebys Medical Discovery Institute and MIT. Dr. Singh is a life member of the National Magnetic Resonance Society at the NMR Research Centre, Indian Institute of Science, Bangalore, India.