Wuts Greene's Protective Groups in Organic Synthesis

5. Auflage 2014
ISBN: 978-1-118-90512-8
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 1408 Seiten, E-Book

An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene's as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology.
* Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching
* Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner
* Adds over 2800 new references to update since thepublication of the last edition
* Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)

Autoren/Hrsg.

Wuts, Peter G. M.

Inhaltsverzeichnis

Preface to the Fifth Edition
Preface to the Fourth Edition
Preface to the Third Edition
Preface to the Second Edition
Preface to the First Edition
Abbreviations
1. The Role of Protective Groups in Organic Synthesis
2. Protection for the Hydroxyl Group, Including 1,2- and 1,3-Diols
Ethers
Esters
Protection for 1,2- and 1,3-Diols
3. Protection for Phenols and Catechols
Protection for Phenols
Protection for Catechols
Protection for 2-Hydroxybenzenethiols
4. Protection for the Carbonyl Group
Acetals and Ketals
Miscellaneous Derivatives
Monoprotection of Dicarbonyl Compounds
5. Protection for the Carboxyl Group
Esters
Amides and Hydrazides
6. Protection for the Thiol Group
Thioethers
Thioesters
Miscellaneous Derivatives
7. Protection for the Amino Group
Carbamates
Amides
Special -NH Protective Groups
Protection for Imidazoles, Pyrroles, and Indoles
Protection for Amides
8. Protection for the Alkyne -CH
9. Protection for the Phosphate Group
Some General Methods of Phosphate Ester Formation
Removal of Protective Groups from Phosphorous
Alkyl Phosphates
Phosphates Cleaved by Cyclodesesterification
Benzyl Phosphates
Phenyl Phosphates
Photochemically Cleaved Phosphate Protective Groups
Amidates
Miscellaneous Derivatives
10. Reactivities, Reagents, and Reactivity Charts
Reactivities
Reagents
Reactivity Charts
Index

Über Autor(innen)

Peter G.M. Wuts is a Distinguished Scientist at Kalexsyn, Inc. in Kalamazoo, Michigan.