Cell-Cell Interactions in the Release of Inflammatory Mediators

Eicosanoids, Cytokines, and Adhesion
1991
ISBN: 978-0-306-44108-0
Verlag: Springer US

Buch, Englisch, 400 Seiten, Book, Gewicht: 880 g

This volume constitutes. in part. the proceedings of the symposium on "Cell-Cell Interaction and Release of Inflammatory Mediators" organized by Drs. Patrick Y-K Wong and Charles N. Serhan and presented at the FASEB meeting in Washington. D.C. in April. 1990. It contains chapters by the symposium speakers as well as contributions from investigators in this field. Readers will find exciting advances in this volume. which contains chapters dedicated to state-of-the-art knowledge in the field of Cell-Cell Interaction and the functions of released mediators in inflammatory diseases. This book includes "cutting edge" investigations on transcellular eicosanoid biosynthesis. cytokines. PAF, and adhesion as well as interactions of inflammatory cells with endothe 1 i um. 1 ung • and kidney. A 1 so. the contro 1 and regu 1 at ion of renal function by lipid mediators generated during cell-cell i nteracti ons between rena 1 mesangi a 1 cells and 1 eukocytes has generated insight into the cell biology and regulatory role of these mediators in the kidney. Moreover. the relationship between these areas is discussed in sequelae of both asthmatic and renal diseases. We hope that some of the enthusiasm and excitement present in this research are also evident here and that this volume will serve as a reference for researchers. teachers. and students to survey thi s rapidly growing field.

Zielgruppe

Research

Autoren/Hrsg.

Wong, Patrick Y-K

Serhan, Charles N.

Inhaltsverzeichnis

IA: Leukocytes, Adhesion and Mediators.- Leukocyte Adhesion: Molecular Basis and Relevance in Inflammation.- Products of Inflammatory Cells Synergistically Enhance Superoxide Production by Phagocytic Leukocytes.- Granulocyte-Macrophage Colony-Stimulating Factor and the Neutrophil: Mechanisms of Action.- IB: Transcellular Eicosanoid Biosynthesis.- Transcellular Metabolism of Arachidonic Acid in Platelets and Polymorphonuclear Leukocytes Activated by Physiological Agonists: Enhancement of Leukotriene B4 Synthesis.- Interactions of Platelets and Neutrophils in the Generation of Sulfidopeptide Leukotrienes.- Red Cell-Neutrophil Interactions in the Regulation of Active Oxygen Species and Lipoxygenase Products.- The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils.- Hepoxilins Modulate Second Messenger Systems in the Human Neutrophil.- II: Vascular Interactions.- Regulated Secretion in Vascular Endothelium.- Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells.- Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4.- III: Paf, Eicosanoids and Cytokines.- PAF and TNF? Interactions in the Pathophysiology of Septic Shock..- LTB4 and PAF in the Cytokine Network.- Platelet-Activating Factor (PAF) — A Putative Mediator in Inflammatory Tissue Injury.- IV: Inflammatory Mediators in Lung.- Transcellular Metabolism of Leukotrienes in the Lung.- The Role of Lipid Mediators in Oxygen-Induced Lung Injury.- Interactions Between Macrophages and Granulocytes in Bronchial Asthma.- Metabolism of Granulocyte-Derived Leukotriene A4 in Human Platelets and Respiratory Tissue: Transcellular Formation of Lipoxins and Leukotrienes.- Metabolism of Arachidonic Acid by Isolated Lung Cells and Transcellular Biosynthesis of Thromboxanes.- V: Cell-Cell Interactions in other Tissues.- The Role of Leukotriene A4 Hydrolase in Cells and Tissues Lacking 5-Lipoxygenase.- Keratinocytes Can Regulate Prostaglandin Synthesis by Fibroblasts: Potential Roles for Interleukin 1.- Neutrophil-Epithelial Cell Interactions in the Intestine.- VI: Inflammatory Mediators and Renal Cell Interaction.- Cell-Cell Interactions in the Regulation of Glomerular Inflammation by Arachidonate Lipoxygenase Products.- Neutrophil Adhesion to Glomerular Mesangial Cells: Regulation by Lipoxygenase-Derived Eicosanoids.- Enzymatic Formation and Regulatory Function of Lipoxins and Leukotriene B4 in Rat Kidney Mesangial Cells.- Contributors.