E-Book, Englisch, 348 Seiten, Web PDF
ISBN: 978-1-4832-6160-7
Verlag: Elsevier Science & Techn.
Format: PDF
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Dr. Robert Turner is currently the owner and CEO of Network Neurology in Charleston SC. He is also Associate Clinical Professor of Neurosciences at the Medical University of South Carolina in Charleston, as well as an Associate Researcher with the MIND Research Institute in Irvine CA. Dr Turner maintains a full-time clinical, teaching, and neurophysiology practice with patients throughout the southeastern region of the United States. While continuing full time work at MUSC since 1997, he obtained a Master's degree in clinical research (epidemiology & biostatistics) in 2003 in the MUSC College of Graduate Studies, and has since then been actively involved in ongoing clinical research with collaborative studies in non-invasive neurostimulation and neuromodulation techniques as well as advanced techniques of EEG source analysis. Current research involves collaborating with colleagues in Charleston, Cape Town, South Africa, Mexico City, Bejing, and with several academic practices throughout the United States. Dr Turner began as a music and foreign language major in college, changing over to pre-medicine in his 3rd year. During medical school, he also pursued Master's training in Piano Performance at the University of Nebraska at Omaha Graduate School. After Medical School, his postgraduate training consisted of internship/residency in Pediatrics followed by two fellowships, one in Adult/Child Neurology, and the second in Clinical Neurophysiology/EMG/Neuromuscular Disorders, and his current clinical/research emphases are pediatric epilepsy/epileptogenesis, the non-linear effects of auditory and music stimulation on the brain, as well as neuromodulation techniques. He continues to pursue his love of music, and is an accomplished classical pianist. He has received numerous awards and honors in Charleston over the past 16 years, including multiple Faculty Excellence Awards for teaching, AREA Awards for excellence in ambulatory care, Golde Apple Nominations and Awards, and double honors in humanism with the AAMC Humanism in Medicine Award and the Leonard Tow Humanism in Medicine AwardDr. Turner is multiply Board-Certificated by the National Board of Medical Examiners, became a certified member of the American Society of Neurorehabilitation in 1992, and has eight medical specialty boards certifications:1. American Board of Psychiatry and Neurology With Special Qualification in Child Neurology,2. American Board of Pediatrics,3. American Board of Electrodiagnostic Medicine, 4. American Board of Clinical Neurophysiology,5. American Board of Psychiatry and Neurology With Added Qualification in Clinical Neurophysiology,6. American Board of Psychiatry and Neurology With Added Qualification in Neurodevelopmental Disabilities ,7. Quantitative Electroencephalograpy (QEEG) Certification Board, and8. American Board of Psychiatry and Neurology With Added Qualification in Epilepsy.
Autoren/Hrsg.
Weitere Infos & Material
1;Front Cover;1
2;Screening Methods in Pharmacology;4
3;Copyright Page;5
4;Table of Contents;10
5;Dedication;6
6;PREFACE;8
7;Chapter 1. INTRODUCTION;18
8;Chapter 2. A BRIEF REVIEW OF THE BIOCHEMISTRY OF THE NERVOUS SYSTEM;20
8.1;I. Chemical Mediators;20
8.2;II. Some Mechanisms of Drug Effects Within the Autonomic System;24
8.3;III. Mechanisms Within the Parasympathetic System;25
8.4;IV. Mechanisms Within the Sympathetic System;28
9;Chapter 3. THE ORGANIZATION OF SCREENING;39
9.1;I. Introduction;39
9.2;II. Further Remarks on Blind Screening;41
9.3;III. Neuropharmacological Tests in Blind Screening;43
9.4;IV. An Alternative Schedule;51
9.5;V. Tests Other than Neuropharmacological;53
9.6;VI. Tests Subsequent to Those in Blind Screening;57
10;Chapter 4. GENERAL METHODS;59
10.1;I. Introduction;59
10.2;II. Tests on Isolated Organs;59
10.3;III. The Guinea Pig Ileum;60
10.4;IV. The Vas Deferens of the Guinea Pig;64
10.5;V. The Jejunum of the Rat;66
10.6;VI. The Seminal Vesicle of the Rat;66
10.7;VII. Seminal Vesicle of the Guinea Pig;67
10.8;VIII. Fundus Strip of the Rat;68
10.9;IX. The Duodenum of the Rat;70
10.10;X. Other Isolated Organs;70
10.11;XI. Cardiovascular Tests (Electrical and Chemical);72
10.12;XII. Food Consumption;75
11;Chapter 5. QUANTAL RESPONSES. CALCULATION OF THE ED;77
11.1;I. Introduction;77
11.2;II. Graphical Calculation of Miller and Tainter;78
11.3;III. Arithmetical Method of Reed and Muench;79
11.4;IV. Arithmetical Method of Kärber;80
11.5;V. The pA Scale;81
11.6;VI. Tests with Superfusion; Drug Antagonism;81
11.7;VII. The Graphical Method of Litchfield and Wilcoxon;84
12;Chapter 6. DEPRESSANTS OF THE CENTRAL NERVOUS SYSTEM;86
12.1;I. Introduction;86
12.2;II. The Righting Reflex;86
12.3;III. Antagonism to Various Chemical Stimulants;87
12.4;IV. Palpebral Test;91
12.5;V. Runway Test for Thirsty Rats;91
12.6;VI. Motor Deficit;92
12.7;VII. Motor Control on an Inclined Plane;92
12.8;VIII. Natatory Exhaustion;93
12.9;IX. Amphetamine Antagonism;94
12.10;X. Motor Activity;95
12.11;XI. Cornea and Pinna Reflexes;95
12.12;XII. Pentylenetetrazol (Metrazol) Antagonism;96
12.13;XIII. A Test Group for Central Depressants;97
12.14;XIV. Central Anesthetics;99
13;Chapter 7. ATARACTIC (TRANQUILLIZING, NEUROLEPTIC) AGENTS;104
13.1;I. Introduction;104
13.2;II. Behavioral Test Group;105
13.3;III. Ratio of Reflexes in the Mouse;109
13.4;IV. Avoidance of Electrical Shock. A Test of Suppression of a Conditioned Response;111
13.5;V. Suppression of Combativeness;111
13.6;VI. Head-Withdrawal Reflex;115
13.7;VII. Yohimbine Syndrome;115
13.8;VIII. Open Field Test;116
13.9;IX. Conclusion;116
14;Chapter 8. ANALGESICS;117
14.1;I. Introduction;117
14.2;II. Narcotic Analgesics;118
14.3;III. Nonnarcotic Analgesics;130
15;Chapter 9. OXYTOCIC AGENTS;135
15.1;I. Introduction;135
15.2;II. Qualitative Test for Uterine Stimulation;135
15.3;III. Quantitative Procedure;136
15.4;IV. Tests Performed on the Uterus in situ;142
16;Chapter 10. ANTISEROTONIN AGENTS;144
16.1;I. The Isolated Uterus of the Rat;144
16.2;II. Isolated Uterus Bathed in Antagonist;145
16.3;III. Uterus Bathed in Antagonist. Alternative Method;146
16.4;IV. Antiedema Test on the Foot of the Rat;147
16.5;V. Cardiovascular Test on the Dog Given Chlorisondamine;148
16.6;VI. Antagonism to Serotonin-Induced Convulsions;148
16.7;VII. Ileum of the Guinea Pig; D Receptors;149
16.8;VIII. Pyretogenic Effects;150
17;Chapter 11. PARASYMPATHOLYTIC AGENTS;152
17.1;I. Mydriasis;152
17.2;II. Antisialagogue Activity;154
17.3;III. Prevention of Intestinal Spasm;156
17.4;IV. Lacrimation;157
17.5;V. Tests in vitro;157
17.6;VI. Gastrointestinal Propulsion;159
18;Chapter 12. SYMPATHOLYTIC AGENTS;160
18.1;I. Introduction;160
18.2;II. Epinephrine Antagonism;160
18.3;III. Prolapse of the Nictitating Membrane;162
18.4;IV. Blood Pressure of the Rat; The ADC;163
18.5;V. Splenic Strip of the Cat;163
18.6;VI. The Two Kinds of Receptor;165
18.7;VII. The Perfused Rabbit Ear;167
19;Chapter 13. ANTI-INFLAMMATORY AGENTS;169
19.1;I. Introduction;169
19.2;II. Pedal Inflammation Induced by Chemical Agents;169
19.3;III. Implantation of a Pellet;175
19.4;IV. Granuloma Pouch;175
19.5;V. Erythema;177
19.6;VI. Tuberculin Sensitivity;177
19.7;VII. Inhibition of Ascites;178
19.8;VIII. Hyaluronidase Inhibition;178
19.9;IX. Pleural Fluid;179
19.10;X. Freund's Adjuvant;179
20;Chapter 14. ANTICONVULSANTS;181
20.1;I. Introduction;181
20.2;II. Convulsions Induced by Chemicals;181
20.3;III. Convulsions Induced by Electroshock;183
20.4;IV. Combined Procedures;183
20.5;V. Tryptamine Potentiation and Antagonism;185
20.6;VI. Tremorine;186
20.7;VII. The Rapid Screening for Myorelaxant Agents;188
21;Chapter 15. SYMPATHOMIMETIC AGENTS;190
21.1;I. Introduction;190
21.2;II. Mydriasis;191
21.3;III. The Uterus and Ascending Colon of the Rat;192
21.4;IV. The Rectal Cecum of the Hen;193
21.5;V. The Isolated Spleen of the Cat;193
22;Chapter 16. CENTRAL STIMULANTS;195
22.1;I. Introduction;195
22.2;II. Analeptic Agents;196
22.3;III. "Sandauswurf" (Displacement of Sand);196
22.4;IV. Registration of Motor Activity;198
22.5;V. Runway Test;198
22.6;VI. Ptosis Test;199
22.7;VII. "Zwangsnagen" Induced by Apomorphine;199
22.8;VIII. Intracerebral Test;201
22.9;IX. Ingestion of Food; Anoretic and Central Stimulant Activity;202
22.10;X. Duration of Anesthesia; Respiratory Analeptics;204
23;Chapter 17. MUSCARING AGENTS;207
23.1;I. The Isolated Eye of Rodents;207
23.2;II. The Isolated Trachea of the Rat;208
24;Chapter 18. GANGLION-BLOCKING AGENTS;210
24.1;I. Introduction;210
24.2;II. Antagonism of Nicotine;211
24.3;III. The Inferior Eyelid of the Rat;212
24.4;IV. The Blood Pressure of the Upright Rabbit;213
25;Chapter 19. ANTIFIBRILLATORY AGENTS;214
25.1;I. Introduction;214
25.2;II. Arrhythmia Induced by Acetylcholine and Potassium Deficiency;215
25.3;III. Arrhythmia Induced by Aconitine;216
25.4;IV. Arrhythmia Induced by Maximum Frequency;217
25.5;V. Ventricular Arrhythmia induced by Calcium;219
26;Chapter 20. CARDIOTONIC AGENTS;220
26.1;I. The Papillary Muscle of the Cat;220
26.2;II. The Atrium of the Cat and the Rat;222
26.3;III. The Aortic Strip of the Rabbit;224
27;Chapter 21. HISTAMINE-LIKE AGENTS;227
27.1;I. Perfusion of the Hind Quarters and the Lung;227
27.2;II. Perfusion of the Skin;228
28;Chapter 22. ANTIHISTAMINE AGENTS;230
28.1;I. Introduction;230
28.2;II. Intravenous Toxicity;231
28.3;III. Histamine Aerosol;231
28.4;IV. Direct Antagonism to Histamine;233
28.5;V. Anaphylactic Microshock;234
28.6;VI. Other Methods;234
29;Chapter 23. ANTITUSSIVE AGENTS;235
29.1;I. Cough Induced by Ammonia in the Cat;235
29.2;II. Cough Induced by Citric Acid in the Guinea Pig;236
29.3;III. Cough Induced by Sulfuric Acid in the Dog;237
30;Chapter 24. ANTACID AGENTS;238
30.1;I. Ulceration and Acidity in the Shay Rat;238
30.2;II. Gastric Perfusion in the Rat;239
30.3;III. The Isolated Heal Segment;241
31;Chapter 25. THYROMIMETIC AGENTS;242
32;Chapter 26. HYPOGLYCEMIC AGENTS;244
33;Chapter 27. CHOLERETIC AGENTS;246
34;Chapter 28. ANTIPARKINSON AGENTS;248
35;Chapter 29. ANTI-INFLAMMATORY AND GLUCOCORTICOIDAL AGENTS;250
36;Chapter 30. ANTIEMETIC AGENTS;252
37;Chapter 31. BRONCHODILATANT AGENTS;255
38;Chapter 32. CURARIFORM AGENTS;257
38.1;I. Paralysis of Intact Animals;257
38.2;II. The Phrenic Nerve and Diaphragm of the Rat;258
38.3;III. The Biventer Cervicis of the Chicken;259
39;Chapter 33. ANABOLIC, ANDROGENIC, AND ANTIANDROGENIC AGENTS;261
40;Chapter 34. POTENTIATORS AND ANTAGONISTS OF TRYPTAMINE;264
41;Chapter 35. VASOPRESSIVE PEPTIDES;266
42;Chapter 36. DIURETIC AND NATRIURETIC AGENTS;268
43;Chapter 37. ANTICHOLINESTEHASE AGENTS;272
44;Chapter 38. ANTICHOLESTEROL AGENTS;276
45;Chapter 39. URICOSURIC AGENTS;279
46;Chapter 40. ANTISHOCK AGENTS;281
47;Chapter 41. HEMOSTATIC AGENTS;283
48;Chapter 42. LOCAL AND SPINAL ANESTHETICS;285
49;Chapter 43. ABORTIFACIENT AGENTS;287
50;Chapter 44. THYMOLEPTIC AGENTS;290
50.1;I. Introduction;290
50.2;II. Qualitative Screening Methods;290
50.3;III. Amine Depletion in the Central Nervous System;292
50.4;IV. Inhibition of Monoamine Oxidase;293
50.5;V. Rats Having Septal Lesions;295
51;Chapter 45. DERMAL IRRITANTS;296
52;Chapter 46. TERATOGENIC AGENTS;299
53;APPENDIX;301
53.1;I. A Summary of Often Used Formulas in Statistics;301
53.2;II. An Approximate Formula for Statistical Significance;303
53.3;III. Statistical Analysis of Responses in Groups of Animals: Salivation in Rabbits;304
53.4;IV. Four-Point Assay of Substances Causing Tachyphylaxis;308
53.5;V. Right-Left Assay;310
53.6;VI. The Composition of Solutions Used for the Bathing of Tissues;314
53.7;VII. Formulas for Use in the Injection of Animals;314
53.8;VIII. An Antipyretic Test;315
53.9;IX. A Test for Dermal Absorption;316
53.10;X. Tests for Hepatotoxicity;316
53.11;XI. Serum Cholesterol;317
53.12;XII. Anesthetics for Laboratory Animals;318
53.13;XIII. Acute Toxicity: The Determination of the LD50;319
53.14;XIV. A Test for the Normal Distribution of a Set of Numbers;321
54;REFERENCES;322
55;AUTHOR INDEX;332
56;SUBJECT INDEX;339
