Biomedical Aspects of Drug Targeting

1. Auflage. Softcover version of original hardcover Auflage 2002
ISBN: 978-1-4419-5312-4
Verlag: Springer US

Buch, Englisch, 506 Seiten, Previously published in hardcover, Format (B × H): 155 mm x 235 mm, Gewicht: 791 g

Drugs usually have no natural affinity for the cells, tissues and organs where therapeutic effects are needed, which frequently results in low efficiency and unwanted side effects. This concern is even more profound when using highly potent and cytotoxic anticancer drugs or specific agents, such as enzymes and genetic materials, since their effective and safe action requires precise cellular or even sub-cellular addressing in the target organ. To meet safety, efficiency and specificity requirements, drugs somehow must be targeted to the sites of their expected therapeutic action. The idea of the "magic bullet," or drug targeting, proposed by Erlich a century ago, generates great and continuously growing interest in biomedical, industrial and financial circles. This book is focused on the strategies designed to target therapeutic or diagnostic agents to the disease sites. In an attempt to include in this volume the set of chapters reflecting both traditional and emerging areas of drug targeting, we have contacted many leading scientists in the field asking for their contributions. Their responses were most favorable and encouraging. As a result, we have succeeded in assembling a series of outstanding contributions reflecting practically all the key areas of drug targeting. The final structure of this book is as follows.

Zielgruppe

Research

Autoren/Hrsg.

Torchilin, Vladimir P.

Muzykantov, Vladimir R.

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Polymerchemie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Kunststoffe und Polymere
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Polymerwerkstoffe

Inhaltsverzeichnis

Section 1: General Principles of Drug Targeting.- 1 Strategies and Means for Drug Targeting: An Overview.- 2 Biological Barriers for Drug Targeting.- Section 2: Cardiovascular Targeting.- 3 Targeting the Pathological Myocardium.- 4 Targeting Atherosclerotic Plaques.- 5 Thrombus Targeting of Plasminogen Activators and Anticoagulants.- 6 Tissue-Specific Pharmacodelivery and Overcoming Key Cell Barriers in Vivo: Vascular Targeting of Calveolae.- 7 Targeting Pulmonary Endothelium.- 8 Targeting Inflammation.- 9 Intravascular Re-Targeting of Viral Vectors.- Section 3: Tumor Targeting.- 10 Polymer-Drug Conjugates: Targeting Cancer.- 11 Enhanced Permeability and Retention (EPR) Effect: Basis for Drug Targeting to Tumor.- 12 Ligand-Directed Destruction of Tumor Vasculature.- 13 Tumor Necrosis Treatment and Imaging of Solid Tumors.- 14 Targeted Apoptosis: Antibodies Linked to Rna Damaging Agents.- 15 Immunotoxins and Antibody-Drug Conjugates for Cancer Treatment.- Section 4: Targeting to Brain.- 16 Blood-Brain Barrier Transport and Drug Targeting to the Brain.- 17 LDL-Receptor Mediated Drug Targeting to Malignant Tumors in the Brain.- 18 Targeting Brain Trauma and Stroke.- 19 Targeting Drugs Into the Central Nervous System.- Section 5: Miscellaneous, New Horizons in Targeting.- 20 Strategies for Targeting Infection.- 21 Anti-HIV Immunotoxins.- 22 Ligand-Mediated Gastrointestinal Targeting.- 23 Transmembrane Targeting of Dna with Membrane Active Peptides.- 24 Polymersomes: A New Platform for Drug Targeting.- 25 Targeting Mitochondria.