Buch, Englisch, 752 Seiten, Format (B × H): 188 mm x 264 mm, Gewicht: 1787 g
Buch, Englisch, 752 Seiten, Format (B × H): 188 mm x 264 mm, Gewicht: 1787 g
Reihe: Handbooks in Pharmacology and Toxicology
ISBN: 978-0-8493-8308-3
Verlag: CRC Press
The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases.
Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented.
This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin
Weitere Infos & Material
General Aspects of Targeted ImagingTargeted Delivery of Imaging Agents: An Overview, G.L. WolfTargeted Gamma Imaging, H.W. StraussDesirable Properties of Antibodies for Imaging, I.F.C. McKenzieDesigner Antibodies as Targeted Diagnostic Units, M.K. Dewanjee and A.N. SerafiniTarget-Specific Imaging AgentsRadiolabeling of Antibodies for Targeted Diagnostics, A.R. Fritzberg and D.S. WilburAntibody-Associated Chelates for Targeted Imagining, Y. AranoChelating Polymer-Based Immunoconjugates for Targeted Diagnostic Imaging, V.P. TorchilinDrug Targeting in Magnetic Resonance Imaging, R. Weissleder, A.A. Bogdanov, Jr., and M. PapisovTargeted Delivery of Imaging Agents by Liposomes, W.T. Phillips and B. GoinsTargeted Imaging of CancerAntibody-Mediated Imaging of Ovarian Cancer, M.E. Schlegel and D.N. KragOvarian Cancer Visualization with Radiolabeled Antibodies, S. Lastiria, E. Vergara, P. Varrella, W. Acampa, and M. SalvatoreTargeted Visualization of Prostate and Prostate Cancer, J.H. Texter, Jr.Targeted Imaging of Colorectal Cancer, C.G. Gourin and D.N. Krag99mTc-MIBI and 201Thallium Scintigraphy in the Follow-Up of Differentiated Thyroid Carcinoma, E. Klemm, A.L. Hotze, B. Vriele, and H.J. BiersackTumor Necrosis Imaging and Treatment of Solid Tumors, A.L. Epstein, L.A. Khawli, F.-M. Chen, M.S. Glasky, and C.R. TaylorPotential of the Avidin-Biotin System for Diagnostic Applications, G. Paganelli, A. Samuel, P. Magnani, A. Siccardi, and F. FazioAvidin-Biotin System for Targeting Metastases: Basic Aspects, J.M. Jeong, T. Saga, J. Lee, and C.-S. KohEpithelial Membrane Antigens as a Taget for Antibody Mediated Imaging, B.R. Davidson, J. Babich, and C. DeanEnhancement of Radiolabeled Monoclonal Antibody Uptake in Tumors with Local Hyperthermia, M.L. Hauck, M.W. Dewhirst, and M.R. ZalutskyTargeted Visualization of Lymph NodesSpecific Imaging Agents for Lymph Nodes, G.L. WolfSystemic Lymph Node Targeting with Macromolecular Imaging Agents, M.I. Papisov, R. Weissleder, and T.J. BradyMagnetic Resonance Imaging of Lymph Nodes with Gd-Containing Liposomes, V.P. Torchilin, V.S. Trubetskoy, and G.L. WolfTargeted Visualization in Cardiovascular DiseasesAntimyosin Scintigraphy for the Detection of Myocyte Necrosis Associated with Various Cardiovascular Disorders, J. Narula, I. Carrió, and B.-A. KhawNoninvasive Imaging of Atherosclerotic Lesions: Monoclonal Antibodies and Other Approaches, B.-A. Khaw, I. Carrió, and J. NarulaRadioimmunodetection of Thrombi, F.T. Lee, A. Scott, and G.J. BautovichTargeting of Radiolabeled Monoclonal Antibody against Angiotensin-Converting Enzyme to the Pulmonary Vasculature, V.R. Muzykantov and S.M. DanilovIntravascular Magnetic Resonance Imaging Contrast Media, P. NiemiProtected Angiopolymers for Vascular Imaging, A.A. Bogdanov, Jr., R. Weissleder, and T.J. BradyCT Diagnostic Media for Blood Pool Imaging, V.S. TrubetskoyTargeted Imaging in Neurological DisordersCerebrovascular and Metabolic Imaging, A.J. Fischman, E.H. Lo, and B.R. RosenNeuroreceptor Imaging in Health and Disease, A.J. Fischman, J.W. Babich, and E.H. LoImaging of Intracellular Signalling in the Brain, Y. Imahori, K. Matsumoto, and S. UedaMiscellaneous Application of Targeted Imaging AgentsHistory of Antibodies for Visualizing Infection and Inflammation, D.A. RauhTargeted Imaging of Focal Sites of Infection, J.W. Babich and A.J. FischmanThe Role of Octreotide Scintigraphy in Malignant Lymphomas, Granulomatous Diseases and Rheumatoid Arthritis, P.M. Vanhagen, P.J. van den Anker-Lugtenburg, S.W.J. Lamberts, J.C. Reuby, and E.P. KrenningTargeted PET/SPECT ImagingSpatial Localization of Primary and Metastic Colorectal Carcinoma Based on Fusion of CR and SPECT Monoclonal Imaging, H. Loats and A. LoatsFluorine-18 Labeled Monoclonal Antibodies for Positron Emission Tomographic Imaging, M.R. Zalutsky, G. Vaidyanathan, P. Garg, and R.L. PageBromine-76 Labeled Monoclonal Antibodies for Targeted PET Imaging, A. Lövqvist, A. Sundin, and H. Lundqvist
