Thubrikar Vascular Mechanics and Pathology

1. Auflage 2007
ISBN: 978-0-387-68234-1
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 520 Seiten, eBook

Nowhere in the scientific progress has the schism in the knowledge been as striking as in the case of vascular mechanics and pathology. This joint subject would serve as a classic example of science developed in two different directions. It provided the motivation to put forth this book and establish a correlation between vascular mechanics and pathology. The book focuses on the artery and arterial diseases. The most fundamental functions of the artery are (1) to serve as a conduit of blood flow and (2) to serve as a container of blood pressure. The artery carries the blood to all organs of the body and it uses pressure to drive the blood through the tissue to provide nourishment. Hence, the artery is both a pipe and a pressure vessel. The artery pulsates about 103,000 times a day along with the beating heart. In a lifetime, the artery sustains cyclic pressure for about 3. 8 billion cycles. This obviously poses a significant challenge to the artery and therefore the artery must be endowed with special structure and properties to meet this challenge. In the event that additional challenges are imposed, such as high blood pressure, it would not be surprising that the artery could “break down” or become diseased. In the book, we examine the structure and properties of the artery and study the challenges imposed on it with a view to understand the survival of and the development of the diseases in the artery.

Zielgruppe

Research

Autoren/Hrsg.

Thubrikar, Mano J.

Inhaltsverzeichnis

Atherosclerosis I.- Atherosclerosis II.- Structure and Mechanics of the Artery.- Pressure Vessel Principles.- Pressure Vessel Intersections.- Stress-Concentration in the Artery I.- Stress-Concentration in the Artery II.- Endothelial Cells and Low-Density Lipoproteins at the Branch.- Smooth Muscle Cells and Stretch.- Stress Reduction and Atherosclerosis Reduction.- The Vein Graft.- Anastomosis.- Anastomotic Aneurysms and Anastomotic Intimal Hyperplasia.- Intracranial Aneurysms.- Aortic Aneurysms.- Aortic Dissection.

Über Autor(innen)

Dr. Mano J. Thubrikar has been with Edwards Lifesciences since December 2004. Previously, he was the Director of the Biomedical Engineering Program at the Heineman Medical Research Center at Carolinas Medical Center, Charlotte, NC. Dr. Thubrikar is a recipient of the Research Career Development Award from the National Institute of Health, the Certificate of Merit awarded by the New York Academy of Medicine, and the Minna-James Heineman Stiftung Research Award for Outstanding Research Achievements in the area of Life Sciences.