Multifunctional Nanoparticles for Cancer Therapeutic Applications

Design and Challenges
Erscheinungsjahr 2025
ISBN: 978-0-443-21686-2
Verlag: Elsevier Science

Buch, Englisch, 600 Seiten, Format (B × H): 191 mm x 234 mm

Multifunctional Nanoparticles for Cancer Therapeutic Applications: Design and Challenges describes the use of multifunctional nanoparticles for cancer treatment, highlighting their toxicological evaluation and opportunities for prospective clinical therapeutic development. Besides significant research and clinical success, cancer nanomedicines currently face challenges towards clinical translation and this book aims to shed a light on complex issues. Sections discuss synthetic strategies and functionalization of nanoparticles, routes of administration, biological barriers and how to overcome them, nanoparticles for cancer treatment available in the market, active targeting approach, non-viral gene-based therapy with multifunctional nanoparticles, and the use of nanoparticles in immunotherapy. In addition, the book covers image guided cancer therapy, stem cell targeted therapy, and toxicity. This is a valuable resource for cancer researchers, oncologists, clinicians, and members of the biomedical field who need to understand the potential of multifunctional nanoparticles in cancer drug delivery, diagnosis, and treatment.

Autoren/Hrsg.

Thomas, Sabu

Samuel Oluwafemi, Oluwatobi

Varghese, Jose

Fachgebiete

• Mathematik | Informatik EDV | Informatik Business Application Unternehmenssoftware
• Wirtschaftswissenschaften Betriebswirtschaft Unternehmensforschung

Inhaltsverzeichnis

1. Synthetic strategies of nanoparticles: scale up strategies and issues
2. Functionalization of nanoparticles
3. Characterization of nano particles intended for tumor therapy
4. Routes of administration of nanoparticles
5. Structures of multifunctional nanoparticle platforms
6. Crossing the biological barriers: multifunctional nanoparticles
7. Nanoparticles for cancer therapeutic application in the market/clinical phases
8. Challenges with active targeting approach using Multifunctional nanoparticles
9. Internal stimuli-responsive targeting system
10. External stimuli-responsive nano system
11. Bio inspired nanomaterials in cancer theragnostic: liposomes, lipids, protein and viral based multifunctional nanoparticles
12. Biomimetic Magnetic Nanoparticles in cancer theragnostic
13. Non-viral gene-based tumor therapy using multifunctional nanoparticles
14. Cancer immunotherapy: mechanism, advantages, and role of nanoparticles
15. Liposomes-Based Nanoparticles for Tumor Therapy and in vivo imaging
16. Quantum Dots for Cancer diagnosis and Therapy
17. Polymeric Nanoparticles for Cancer diagnosis and Therapy
18. Stem cell targeted cancer therapy: role of nanoparticles
19. Gold Nanoparticles for tumor Imaging and Therapy
20. Image guided cancer therapy: a new approach using multifunctional nanoparticle
21. Protein corona over nanoparticles: implications and strategies for cancer therapy
22. Multifunctional nanoparticle induced toxicity: invitro, in vivo and its bioelimination

Über Autor(innen)

Samuel Oluwafemi, Oluwatobi
Professor Oluwafemi is a fully-fledged academic that is involved in Teaching & Learning, Research, Community Engagement, staff and student mentorship among many other activities. His research interest is in the synthesis of binary, ternary and quaternary semiconductor nanomaterial and nanostructures such as quantum dots, metal nanomaterials, core-shells, doped nanostructures and polymer nanocomposites for different applications which includes biological, (basically for cancer treatment ie imaging, labelling, drug delivery photodynamic therapy and photothermal therapy), optical (development of optical devices), environmental (sensing and determination of environmental pollutants), nanotoxicology and water treatment. He is also involved in the indigenous knowledge system (IKS) for value added chain using different South African medicinal plants. This involves isolation, extraction, biological activity testing, and synthesis of nanomaterial using the plant extract and packaging for pharmaceutical purposes.

Varghese, Jose
Jose Varghese R is a PhD researcher in Department of Chemical Science, University of Johannesburg, South Africa. He has received an integrated master's degree in Nanoscience and Nanotechnology from Karunya University, Tamil Nadu, India. He has attended various internships and training including from Denmark Technical University. He is currently pursuing his research on designing of multifunctional nanoparticles for cancer imaging and drug delivery. He has published in international journals regarding drug delivery and imaging using nanoparticles and mesoporous silica with book chapter relating to the same.

Thomas, Sabu
Prof. Sabu Thomas is the Director of the International and Interuniversity Centre for Nanoscience and Nanotechnology at Mahatma Gandhi University in Kerala, India. He also serves as the Chairman of Trivandrum Engineering Science and Technology Research Park (TrESPARK) in Kerala, India. Formerly, he was the Vice Chancellor of Mahatma Gandhi University. His ground-breaking research has covered the areas of polymer science and engineering, polymer nanocomposites, elastomers, polymer blends, interpenetrating polymer networks, polymer membranes, green composites and nanocomposites, nanomedicine, and green nanotechnology. Prof. Thomas has received several national and international awards in recognition for his work and recently received Honoris Causa (DSc) from the University of South Brittany, Lorient, France, in recognition for his contributions to polymer science and engineering. Prof. Thomas has published more than 1400 peer-reviewed research papers, reviews, and book chapters. He has also edited and written 210 books. His H-index stands at 139, accompanied by a citation count of 43,000.