Systemic Sclerosis

1. Auflage 2016
ISBN: 978-4-431-55707-4
Verlag: Springer Japan

Buch, Englisch, 247 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 5552 g

This book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Takehara, Kazuhiko

Kuwana, Masataka

Fujimoto, Manabu

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Dermatologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1.- Fibrosis: overview 2.- Autoimmunity in systemic sclerosis: Overview 3.- Endothelial progenitor cell 4.- Animal models of systemic sclerosis 5.- Genetics of Systemic Sclerosis 6.- Role of the Interleukin-1 Family in the Fibrogenic Phenotype in Systemic Sclerosis 7.- Interleukin-6 in the Pathogenesis of Systemic Sclerosis 8.- Epigenetics 9.- Transforming Growth Factor-ß and Connective Tissue Growth Factor 10.- Endothelin 11.- The Role of B cells in Systemic Sclerosis 12.- Fli1 13.- Biomarker 14.- Autoantibodies in Systemic Sclerosis

Über Autor(innen)

Dr. Kazuhiko Takehara
Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan

Dr. Manabu Fujimoto
Department of Dermatology, University of Tsukuba, Japan

Dr. Masataka Kuwana
Department of Allergy and Rheumatology, Nippon Medical School, Japan