Sugi Mysteries in Muscle Contraction

Evidence Against Current Dogmas
Erscheinungsjahr 2018
ISBN: 978-1-351-59048-8
Verlag: Taylor & Francis
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 302 Seiten

The book explores author’s wide-ranging work on muscle research for more than 50 years. It delves into the dogmas of muscle contraction, how the models were constructed and what was overlooked during the process, including their resulting shortcomings. In all chapters, the author intends to stimulate interest of general readers and specific researchers which also highlights the author’s pioneering work on the electron microscopic recording of myosin head power and recovery strokes, including a frank discussion on how the original work sometimes tends to be overlooked by competing scientists, who hinder the progress of science.

Zielgruppe

Advanced undergraduate and graduate level students in physiology, biochemistry, and biophysics; researchers in muscle physiology, muscle biochemistry, muscle biophysics, and muscle biology, especially those who are interested in the mechanism of muscle contraction; researchers in sports medicine.

Autoren/Hrsg.

Sugi, Haruo

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Anatomie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Naturwissenschaften Physik Physik Allgemein

Inhaltsverzeichnis

Historical Background
Dogmas of Huxley-Simmons Model not Supported Experimentally

New Methods and New Dogmas and Their Shortcomings
The Swinging Lever Arm Hypothesis: A Most Prominent Current Dogma
Dynamic Electron Microscopy on Myosin Head Movement Using Quick-Freeze, Deep-Etch Replica Method

Electron Microscopic Recording of ATP-Induced Myosin Head Movement

Evidence against Current Dogmas of Muscle Contraction as Revealed by the Effect of Antibodies to Myosin Head
Electron Microscopic Recording of Myosin Head Power Stroke: Possible Sequence of Actin-Myosin Interaction in Muscle
The Fenn Effect: A Fundamental Mystery in Muscle
Load-Dependent Mechanical Efficiency of Myosin Heads
Past History Dependence of Myosin Head Performance
Reminiscences of My Early Work I. Summation of Force Responses in Muscle
Reminiscences of My Early Work II. Transverse Spread of Contraction Initiated by Local Membrane Depolarization in Single Muscle Fibers

Über Autor(innen)

Haruo Sugi graduated from the Postgraduate School in the University of Tokyo, Japan, with a PhD in 1962 and was appointed instructor in the Department of Physiology at the University of Tokyo. From 1965 to 1966, he worked at Columbia University as a research associate and at the National Institutes of Health as a visiting scientist. He was a professor and chairman of the Department of Physiology, Teikyo University Medical School, Japan, from 1973 to 2004, when he became emeritus professor.