Stromgaard / Krogsgaard-Larsen / Madsen Textbook of Drug Design and Discovery, Fifth Edition

5. Auflage 2016
ISBN: 978-1-4987-0279-9
Verlag: CRC Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 450 Seiten

Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

Autoren/Hrsg.

Stromgaard, Kristian

Krogsgaard-Larsen, Povl

Madsen, Ulf

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein

Inhaltsverzeichnis

Introduction to Drug Design and Discovery
Ulf Madsen and Povl Krogsgaard-Larsen

Molecular Recognition
Thomas Balle and Tommy Liljefors

Ligand-Based Drug Design
Erica S. Burnell, David E. Jane, and Robert J. Thatcher

Biostructure-Based Drug Design
Flemming Steen Jørgensen and Jette Sandholm Kastrup

Drug-Like Properties and Decision Making in Medicinal Chemistry
Jan Kehler, Lars Kyhn Rasmussen, and Morten Jørgensen

Chemical Biology
Louise Albertsen and Kristian Strømgaard

Natural Products in Drug Discovery
Guy T. Carter

In Vivo Imaging in Drug Discovery
Jesper L. Kristensen and Matthias M. Herth

Peptide and Protein Drug Design
Jesper Lau and Søren Østergaard

Prodrugs in Drug Design and Development
Jarkko Rautio and Krista Laine

Enzyme Inhibitors: Biostructure- and Mechanism-Based Design
Robert A. Copeland and P. Ann Boriack-Sjodin

Receptors: Structure, Function, and Pharmacology
Hans Bräuner-Osborne

Ion Channels: Structure and Function
Søren-Peter Olesen, Bo Hjorth Bentzen, and Daniel B. Timmermann

Neurotransmitter Transporters: Structure, Function, and Drug Binding
Claus J. Løland and Ulrik Gether

GABA and Glutamic Acid Receptor and Transporter Ligands
Bente Frølund and Lennart Bunch

Acetylcholine
Anders A. Jensen

Histamine Receptors
Iwan de Esch, Henk Timmerman, and Rob Leurs

Dopamine and Serotonin
Benny Bang-Andersen, Lena Tagmose, and Klaus P. Bøgesø

Opioid and Cannabinoid Receptors
Rasmus P. Clausen and Harald S. Hansen

Neglected Diseases
Søren B. Christensen and Ib C. Bygbjerg

Anticancer Agents
Fredrik Björkling, José Moreira, and Jan Stenvang

Targeting Receptor Tyrosine Kinases
Bo Falck Hansen and Steen Gammeltoft

Antibiotics
Smitha Rao C.V., Piet Herdewijn, and Anastassios Economou

Über Autor(innen)

Kristian Strømgaard is a professor of chemical biology in the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, at the University of Copenhagen and a director of the Center for Biopharmaceuticals, Copenhagen, Denmark. He earned his master’s degree in chemical research from the Department of Chemistry at the University College London under the supervision of Professor C. Robin Ganellin and his PhD in medicinal chemistry from the Royal Danish School of Pharmacy (now School of Pharmaceutical Sciences). Dr. Strømgaard also is cofounder of a biotech company, Avilex Pharma, which explores peptidebased inhibitors of protein–protein interactions as a novel treatment for stroke.

Povl Krogsgaard-Larsen is a professor of medicinal chemistry in the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, at the University of Copenhagen, Copenhagen, Denmark. In 1970, he earned his PhD in natural product chemistry from the former Royal Danish School of Pharmacy. In 1980, Dr. Krogsgaard-Larsen earned his DSc. He has published nearly 460 scientific papers and edited a number of books, and during the period 1998–2013, he was editor of the Journal of Medicinal Chemistry. He has been awarded honorary doctorates at the universities of Strasbourg (1992), Uppsala (2000), and Milan (2008), apart from receiving numerous other scientific awards and prizes.

Ulf Madsen is currently director at the School of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. In 1988, he earned his PhD in medicinal chemistry from the Royal Danish School of Pharmacy, where he later became an associate professor in the Department of Medicinal Chemistry. Dr. Madsen has been a visiting scientist at the University of Sydney, Australia; at Johan Wolfgang Goethe University, Frankfurt, Germany; and at Syntex Research, California. He has extensive research experience with design and synthesis of glutamate receptor ligands. His work has led to 120 scientific papers.