Plant-Based Drug Discovery

Unveiling Molecular Targets for Metabolic Conditions
Erscheinungsjahr 2025
ISBN: 978-0-443-31698-2
Verlag: Elsevier Science

Buch, Englisch, 400 Seiten, Format (B × H): 191 mm x 235 mm

Plant-Based Drug Discovery: Unveiling Molecular Targets for Metabolic Conditions provides an in-depth examination of the molecular mechanisms of phytochemicals and their potential in treating metabolic diseases. This comprehensive guide begins with an introduction to the prevalence and impact of metabolic disorders, emphasizing the significant role of phytochemicals in their management. The book delves into scientific concepts and research findings, offering valuable insights for researchers and healthcare professionals in the fields of molecular biology, biochemistry, pharmacology, and biotechnology. Chapters cover various crucial topics such as oxidative stress, epigenetic mechanisms, and mitophagy.

In addition, they explore the targeting of molecular chaperones and the molecular targets of plant nutraceuticals for treating obesity, cardiovascular disease, and type 2 diabetes. The book also addresses technological advances, including AI and nanotechnology, highlighting opportunities and challenges in improving the use of plant molecules for metabolic disorder treatments. It serves as an essential resource for those engaged in drug discovery and related areas.

Autoren/Hrsg.

Srivastava, Akhileshwar Kumar

Bisht, Mamta

Singh, Ajay

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Section 1: Introduction
1. Overview of human metabolic diseases associated with lifestyle

Section 2: Phytochemicals and molecular targets
2. Significance of phytochemicals in metabolic disorders
3. Molecular connection of oxidative stress and metabolic syndrome: Therapeutic role of phytocomponents
4. Epigenetic mechanisms of phytochemicals in cure of metabolic diseases
5. Plant-derived bioactive peptides for treatment of metabolic disorders
6. Efficiency of phytochemicals to cure metabolic diseases by targeting mitophagy
7. Phytochemicals as promising therapeutic approaches for inflammasome-related metabolic diseases
8. Regulatory impact of phytochemicals on metabolic diseases by targeting Nrf2-ARE signaling mechanism
9. Targeting molecular chaperones with phytochemicals for drug discovery in metabolic ailments
10. Molecular targets of plant nutraceuticals against obesity
11. Molecular insight to cure cardiovascular diseases through plants compounds
12. Mechanistic insights of important medicinal plant compounds in managing type 2 diabetes mellitus

Section 3: Nanotechnology methods
13. Attenuation of hyperlipidemia by medicinal plants with nanotechnological methods

Section 4: Clinical study
14. Clinical evidences of phytochemicals in cure of metabolic diseases

Section 5: Technologies and challenges for plant-based drug discovery
15. Artificial intelligence in plant-based drug discovery against metabolic disorders
16. Integration of high-throughput omics technologies in discovery of phytodrugs to treat metabolic diseases
17. Multi-targets drug design for screening of phytochemicals to cure of metabolic disorders
18. New opportunities and challenges for improving the druggability of plant product against metabolic disorders

Über Autor(innen)

Bisht, Mamta
Dr. Mamta Bisht is presently working as an Assistant Professor in the Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University (NAAC A+), Dehradun, Uttarakhand, India. She is actively involved in the extraction, isolation, characterization of natural products obtained from the medicinal and aromatic plants with bioactivity. Furthermore she is involved in the promotion of endangered and economically important species from the youngest Himalayan region. She has published ten papers in peer-reviewed international journals and four book chapter. Further to this, she has participated in over ten national and international conferences. She is a lifetime member of the Indian Science Congress Association. Under her guidance two P.G. and one U.G. student successfully completed their project thesis and she also guides the PhD students in the university.

Singh, Ajay
Professor Ajay Singh is currently working as Dean of Sciences and Research and Studies in Uttaranchal University, Dehradun, India. He has more than 20 years of research experience. He has published more than 50 research articles in reputed journals and several chapters during his research work. More than 5 patents and projects are also credited to him. He has also written 2 academic books for UG and PG students. He has guided more than 50 students for project thesis of U.G and P. G. students and awarded more than 5 PhD students and several are registered under him. He is the recipient of the Young Scientist award by Scientific Planet Society India and several other awards.

Srivastava, Akhileshwar Kumar
Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) in CSIR-Central Food Technological Research Institute, Mysore, India. In his eight years of research, he has published approximately 20 research articles and book chapters in international and national journals of repute. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology-associated targeting cancer diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, United States on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in Indian Science Congress and Agriculture, Nutrition and Health Academy, United Kingdom.