Smith RNA and DNA Editing

Molecular Mechanisms and Their Integration into Biological Systems
1. Auflage 2008
ISBN: 978-0-470-26225-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 456 Seiten, E-Book

RNA and DNA Editing assembles a team of leading experts who present the latest discoveries in the field alongside the latest models and methodology. In addition, the authors set forth the many open questions and suggest routes for further investigation. Overall, the book serves as a practical guide for professionals in the field who need to understand the interrelationship of RNA and DNA editing with other chemical and biological processes.

Autoren/Hrsg.

Smith, Harold C.

Inhaltsverzeichnis

Preface.
Acknowledgements.
Contributors.
Part I: Diversification of the Proteome through RNA and DNAEditing.
Chapter 1. Diversifying Exon Code Through A-To-I RNAEditing.
Chapter 2. Antibody Gene Diversification by Aid-Catalyzed DNAEditing.
Chapter 3. Protein-Protein and RNA-Protein Interactions inU-Insertion/Deletion RNA Editing Complexes.
Chapter 4. Machinery of RNA editing in Plant Organelles.
Part II: Functional Coordination of RNA Editing With OtherCellular Mechanisms.
Chapter 5. Transfer RNA Editing Enzymes: At the Crossroads ofAffinity and Specificity.
Chapter 6. A-To-I Editing as a Co-Transcriptional RNA ProcessingEvent.
Chapter 7. Studying and Working with Ribonucleoproteins thatCatalyze H/ACA Guided RNA Modification.
Chapter 8. Functional Roles of Spliceosomal SNRNAModifications in Pre-mRNA Splicing.
Chapter 9. A Role for A-To-I Editing in Gene Silencing.
Chapter 10. biological Implications and Broader-Range FunctionsFor Apobec-1 and Apobec-1 Complementation Factors (ACF)
Chapter 11. Antiviral Function of APOEC3 CytidineDeaminases.
Part III: Predictive Structures.
Chapter 12. A-To-I Editing of ALU Repeats.
Chapter 13. RNA Editing in Dinoflagellates and Implications forthe Evolutionary History of the Editing Machinery.
Part IV: Structural Approaches.
Chapter 14. The Box C/D RNPs: Evolutionarily Ancient NucleotideModification Complexes.
Chapter 15. Structural Features of the Adar Family of Enzymesand Their Substrates.
Chapter 16. Chemistry, Phylogeny, and three-DimensionalStructure of the Apobec Protein Family.
Index.

Über Autor(innen)

Harold C. Smith, PhD, is Professor in the Department of Biochemistry and Biophysics at the University of Rochester and the founder and Chief Scientific Officerof OyaGen, a biotech company that develops drugs that target editing enzymes. Dr. Smith organized the first Gordon Research Conference on RNA Editing in 1997 and holds four patents.