Neurotransmitter Transporters

Investigative Methods
1. Auflage 2016
ISBN: 978-1-4939-3763-9
Verlag: Springer

Buch, Englisch, Band 118, 229 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 6075 g

Reihe: Neuromethods

The volume aims at providing an overview of cutting-edge methods and protocols used in neuroscience and neurological research. Neurotransmitter Transporters: Investigative Methods will be of interest to scientists, graduate students, and advanced undergraduates who seek an overview of methods and protocols in this field of neuroscience. It will also be of interest to physicians who are carrying out imaging and postmortem studies of neurotransmitter transporters in the human brain. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.

Authoritative and practical, Neurotransmitter Transporters: Investigative Methods aims to ensure successful results in the further study of this vital field.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Sitte, Harald H.

Bönisch, Heinz

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Classical Radioligand Uptake and Binding Methods in Transporter Research: An Emphasis on the Monoamine Neurotransmitter Transporters.- Tracer Flux Measurements to Study Outward Transport by Monoamine Neurotransmitter Transporters.- Interrogating the Activity of Ligands at Monoamine Transporters in Rat Brain Synaptosomes.-- Using High-Speed Chronoamperometry to Measure Biogenic Amine Release and Uptake In Vivo.- Experimental Data Guided Docking of Small Molecules Into Homology Models Of Neurotransmitter Transporters.- Immunohistochemical Methods for the Study of the Expression of Low-Affinity Monoamine Transporters in the Brain.- Analysis of Neurotransmitter Transporter Posttranslational Modifications: Phosphorylation and Palmitoylation.- Ensemble and Single Quantum Dot Fluorescence Methods in Neurotransmitter Transporter Research.- Approaches for Investigating Transporter Endocytic Trafficking In Cell Lines and Native Preparations.- Organic Cation Transport Measurements Using Fluorescence Techniques.- Animal Models for Depression and the Mode of Action of Neurotransmitter Transporter-Blocking Antidepressants.- In-Vivo Imaging of Dopamine Metabolism and Dopamine Transporter Function in the Human Brain.