Chemistry of the Morita-Baylis-Hillman Reaction

Erscheinungsjahr 2011
ISBN: 978-1-84973-129-4
Verlag: RSC Publishing

Buch, Englisch, 563 Seiten, Format (B × H): 158 mm x 240 mm, Gewicht: 894 g

Carbon-carbon bond formations and functional group transformations are the most fundamental reactions for the construction of molecular frameworks and are at the forefront of organic chemistry research. The Morita-Baylis-Hillman (MBH) type reactions possess the two most important requirements - atom economy and generation of multi-functional groups. The last decade has seen exponential growth of the MBH reaction and its applications. In fact, it is already one of the most powerful carbon-carbon bond-forming methods widely used in organic synthesis. Since the 1990s, more and more research groups have initiated work on different aspects of the MBH reaction. These have focused on the scope of the substrates, novel catalysts (especially chiral catalysts), reaction mechanisms, and synthetic applications. Consequently, there is now a need for a reference detailing the chemistry of this important reaction. This unique book summarizes the MBH reaction, aza-MBH reaction and asymmetric MBH/aza-MBH reaction including the latest research and mechanistic investigations. It provides a complete overview of MBH-type reactions aimed at synthetic organic chemists of all levels within academia and industry. The chapters cover the; origin and growth of the Morita-Baylis-Hillman reaction; reactant classes and reaction conditions; catalytic mechanisms; achiral and chiral catalytic systems; transformations of functional groups; use of Morita-Baylis-Hillman adducts and derivatives as starting materials to construct compounds with carbocyclic or heterocyclic frameworks, and the applications of the MBH reaction in synthesizing natural products.

Autoren/Hrsg.

Shi, Min

Zhao, Mei-Xin

Wei, Yin

Wang, Feijun

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Physikalische Chemie Chemische Reaktionen, Katalyse

Inhaltsverzeichnis

Morita-Baylis-Hillman Reaction;

Catalytic System for the Morita-Baylis-Hillman Reaction;

Transformations of Functional Groups in Morita-Baylis-Hillman Adducts;

Morita-Baylis-Hillman Adducts or Derivatives for the Construction of Cyclic Frameworks;

The application of Morita-Baylis-Hillman Reaction for the Synthesis of Natural Products

Über Autor(innen)

Shi, Min
I am currently a professor of organic chemistry in the State Key Lab. of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, where I have been for ten years. My research focuses on the organic synthesis, asymmetric catalysis, organocatalysis, and chemical fixation of CO2. With my twenty years research experiences in these fields, I have a broad body of knowledge in organic chemistry and organometallics and I am familiar with the frontier work in these areas. My research work was published on the most prestigious journals in the world, such as Angew. Chem. Int. Ed., J. Am. Chem. Soc., Chem. Eur. J., Adv. Synth. & Catal., etc. Thus far, I have published 312 regular papers in above journals. I am also a regularly invited reviewer to evaluate submitted scientific papers for multiple journals. In my research career, I have accomplished several significant jobs on aza-Morita-Baylis-Hillman reaction. Please see the following references.

Wang, Feijun
Feijun Wang was born in Shangyu, Zhejiang Province, People's Republic of China, in 1978. He received his B.Sc. degree in 2001 and his M.Sc. degree in 2004 form China University of Mining and Technology. After obtaining his Ph.D degree in the field of synthesis of novel oxazoline ligands with a biphenyl backbone and their applications in asymmetric catalysis in 2007 from School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, he joined the group of Professor Min Shi. His research program is focused on the development of novel rotation restricted ligands and their applications in asymmetric catalysis.

Min Shi has been a professor of organic chemistry in the State Key Laboratory of Organometallic Chemistry at the Shanghai University of Organic Chemistry (SIOC) within the Chinese Academy of Science for the past ten years. Professor Shi's research focuses on the organic synthesis, asymmetric catalysis, organocatalysis, and chemical fixation of CO2. With twenty years experience in the field, Min Shi has published over 300 articles in the most prestigious publications in the field and is also regularly invited to review articles submitted for publication in many academic journals. Feijun Wang obtained a BSc and MSc from the China University of Mining and Technology. After receiving his PhD (on the synthesis of novel ozaloline ligands with a biphenyl backbone and their applications in asymmetric catalysis) from the Shanghai Jiao Tong University School of Chemistry and Technology, he joined the group of Professor Min Shi. His research now focuses on the development of novel rotation restricted ligands and their applications in asymmetric catalysis.