Shafrir Animal Models of Diabetes, Second Edition

Frontiers in Research
2. Auflage 2007
ISBN: 978-1-4200-0945-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 384 Seiten

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes. The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease. Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Zielgruppe

Laboratory animal scientists, researchers specializing in diabetes, endocrinologists, physiologists, biochemists, and geneticists.

Autoren/Hrsg.

Shafrir, Eleazar

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Diabetologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Rat Models of Type 1 Diabetes, Genetics Environment, and Autoimmunity, J.P. Mordes, P. Poussier, A.A. Rossini, E.P. Blankenhorn, and D.L. Greiner
The NOD Mouse and its Related Strains, H. Taniguchi, S. Makino, and H. Ikegami
Obesity/Diabetes in Mice with Mutations in Leptin or Leptin Receptor Genes, S. Chua, Jr., L. Herberg, and E.H. Leiter
The Zucker Diabetic Fatty (ZDF) Rat—Lessons from a Leptin Receptor Defect Diabetic Model, R.G. Peterson
The Goto–Kakizaki Rat, C.-G. Östenson
The New Zealand Obese Mouse: Polygenic Model of Obesity, Glucose Intolerance, and the Metabolic Syndrome, B.C. Fam and S. Andrikopoulos
The JCR:LA-cp Rat: Animal Model of the Metabolic Syndrome Exhibiting Micro- and Macrovascular Disease, J.C. Russell, S.E. Kelly, and S.D. Proctor
The SHROB (Koletsky) Rat as a Model for Metabolic Syndrome, R.J. Koletsky, R.A. Velliquette, and P. Ernsberger
OLETF Rats: Model for the Metabolic Syndrome and Diabetic Nephropathy in Humans, K. Kawano
Neonatally Streptozotocin-Induced (n-STZ) Diabetic Rats: A Family of Type 2 Diabetes Models, B. Portha, J. Movassat, C. Cuzin-Tourrel, D. Bailbe, M. H. Giroix, P. Serradas, M. Dolz, and M. Kergoat
The Rhesus Monkey (Macaca mulatta) Manifests all Features of Human Type 2 Diabetes, B.C. Hansen and X.T. Tigno
Pigs in Diabetes Research, with Special Focus on Type 2 Diabetes Research, M.O. Larsen and B. Rolin
Psammomys Obesus: Nutritionally Induced Insulin Resistance, Diabetes, and Beta Cell Loss, E. Ziv, R. Kalman, and E. Shafrir
The Spontaneously Diabetic Torii (SDT) Rat with Retinopathy Lesions Resembling Those of Humans, M. Shinohara, T. Masuyama, and A. Kakehashi
Cohen Diabetic Rat, S. Weksler-Zangen, E. Orlanski, and D.H. Zangen
KK and KKA y Mice: Models of Type 2 Diabetes with Obesity, S. Taketomi
Animal Models to Study Obesity and Type 2 Diabetes Induced by Diet, T. Coskun, Y. Chen, D. Sindelar, and M. Heiman Index