Seneci Solid-Phase Synthesis and Combinatorial Technologies

1. Auflage 2003
ISBN: 978-0-471-46073-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 656 Seiten, E-Book

A unique, integrated look at solid-phase synthesis and advancesin combinatorial chemistry and technologies
The last decade has seen a rapid expansion in combinatorialtechnologies, a field where chemistry disciplines intersect withautomation, statistics, and information science, as well as certainbiological disciplines. Reflecting these multidisciplinary trends,this new work provides a comprehensive overview of the mostimportant aspects of solid-phase synthesis (SPS), combinatorialchemistry, and related combinatorial technologies. It clearlydemonstrates how SPS and combinatorial chemistry have extendedtheir application from the pharmaceutical arena to new areas,including biotechnology, material sciences, catalysis, andagrochemical industries, and explores in detail strategies forplanning, designing, preparing, and testing of combinatoriallibraries in various disciplines. Designed to meet the needs ofboth experienced combinatorial chemists and newcomers to the field,Solid-Phase Synthesis and CombinatorialTechnologies:
* Surveys the most recent developments in SPS and combinatorialchemistry
* Explains the entire process, from determining the need for alibrary to the details necessary for synthesis of the library
* Discusses choice of format, size, and the rationale behind thedesign of each synthetic step
* Surveys the analytical techniques and the purification methodsused to characterize and purify combinatorial libraries
* Employs a large number of examples to illustrate importantconcepts
* Includes problems geared toward applying acquired knowledge anddesigning the steps to SPS/library synthesis
* Describes the quality control and activity screening ofcombinatorial libraries for various applications
* Features a detailed bibliography of more than 1,700 relevantsources

Autoren/Hrsg.

Seneci, Pierfausto

Inhaltsverzeichnis

Solid-Phase Synthesis: Basic Principles.
Solid-Phase Synthesis: Oligomeric Molecules.
Solid-Phase Synthesis: Small Organic Molecules.
Combinatorial Technologies: Basic Principles.
Synthetic Organic Libraries: Library Design and Properties.
Synthetic Organic Libraries: Solid-Phase Discrete Libraries.
Synthetic Organic Libraries: Solid-Phase Pool Libraries.
Synthetic Organic Libraries: Solution-Phase Libraries.
Applications of Synthetic Libraries.
Biosynthetic Combinatorial Libraries.
Materials and Polymeric Combinatorial Libraries.
Index.

Über Autor(innen)

PIERFAUSTO SENECI, PhD, is Associate Director of Chemistry at the Glaxo Wellcome Medicines Research Centre, Verona, Italy.