Handbook of Fluorescent Dyes and Probes

1. Auflage 2015
ISBN: 978-1-118-02869-8
Verlag: Wiley

Buch, Englisch, 464 Seiten, Format (B × H): 221 mm x 286 mm, Gewicht: 1425 g

A COMPLETE, UP-TO-DATE RESOURCE OF INFORMATION ON MORE THAN 150 FLUORESCENT DYES AND PROBES

Handbook of Fluorescent Dyes and Probes is the most comprehensive volume available on the subject, covering all the available dyes and probes known to date in the literature for uses in various fields. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, color, material, physical and related allied fields. The ease of use of the handbook is further enhanced by various appendixes provided at the end of the book to conveniently and easily locate the dye as per the reader's need.

This is the first book to give the CAS registry numbers, chemical structure, Chemical Abstract (CA) index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pKa, absorption maxima, emission maxima, molar extinction coefficient, and quantum yield of fluorescent dyes and probes, as well as to provide access to synthetic procedures (lab scale and industrial scale) of dyes and probes in a single source. This user-friendly handbook also features references on safety, toxicity and adverse effects of dyes and probes on humans, animals and the environment, including:

acute/chronic toxicity
aquatic toxicity
carcinogenicity
cytotoxicity
ecotoxicity
genotoxocity
hematotoxicity
hepatotoxicity
immunotoxicity
marine toxicity
microbial toxicity
mutagenicity
nephrotoxicity
neurotoxicity
nucleic acid damage
oral toxicity
phototoxicity
phytotoxicity
reproductive toxicity
skin toxicity

Containing imaging/labeling applications, biological/medical applications and industrial applications, Handbook of Fluorescent Dyes and Probes is a convenient, vital resource for industrial and academic researchers, and a valuable desktop reference for medical professionals, lab supervisors, scientists, chemists, biologists, engineers, physicists, intellectual property professionals, students, and professors.

- Includes all fluorescent dyes & probes known to date and provides a complete, up-to-date library of information in one reference/handbook
- Includes more than 300 fluorescent dyes & probes organized alphabetically by the commonly used Chemical Name
- Provides access to synthesis procedures (lab scale and industrial scale) of fluorescent dyes & probes
- First book to provide references on safety, toxicity and adverse effects of fluorescent dyes and probes on humans, animals, and the environment
- User-friendly and convenient resource guide for chemical, biological, medical, and intellectual property professionals in a broad range of disciplines

Autoren/Hrsg.

Sabnis, R W

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Technologie der Lacke, Farben und Pigmente

Inhaltsverzeichnis

Preface xv

About the Author xvii

Acridine Homodimer 1

Acridine Orange (AO) 3

Acridine Orange 10-dodecyl Bromide (dodecyl-acridine Orange (DAO)) 10

Acridine Orange 10-nonyl Bromide (nonyl-acridine Orange (NAO)) 12

Alexa Fluor 350 Carboxylic Acid Succinimidyl Ester (AMCA-S) 15

Alexa Fluor 430 Carboxylic Acid Succinimidyl Ester 17

Alexa Fluor 488 Carboxylic Acid Succinimidyl Ester 20

Alexa Fluor 514 Carboxylic Acid Succinimidyl Ester 23

Alexa Fluor 532 Carboxylic Acid Succinimidyl Ester 25

Alexa Fluor 555 Carboxylic Acid Succinimidyl Ester 28

Alexa Fluor 594 Carboxylic Acid Succinimidyl Ester 30

Alexa Fluor 633 Carboxylic Acid Succinimidyl Ester 33

Alexa Fluor 660 Carboxylic Acid Succinimidyl Ester 35

Alexa Fluor 680 Carboxylic Acid Succinimidyl Ester 38

Alexa Fluor 700 Carboxylic Acid Succinimidyl Ester 40

Alexa Fluor 750 Carboxylic Acid Succinimidyl Ester 42

Alexa Fluor 790 Carboxylic Acid Succinimidyl Ester 45

9-amino-6-chloro-2-methoxyacridine (ACMA) 46

4-amino-5-methylamino-2',7'-difluorofluorescein (DAFFM) 50

4-amino-5-methylamino-2',7'-difluorofluorescein Diacetate (DAF-FM DA) 52

7–amino-4-methylcoumarin (AMC) (Coumarin 120) (Coumarin 440) 54

8-aminopyrene-1,3,6-trisulfonic Acid Trisodium Salt (APTS) 63

7-anilinocoumarin-4-acetic Acid (ACAA) 65

9-anthroylnitrile 66

Bobo 1 69

Bobo 3 71

Bodipy Fl C5-ceramide (C5-DMB-ceramide) 74

Bodipy Fl C5-ganglioside Gm 1 77

Bodipy Fl C5-lactosylceramide 79

Bodipy Fl C5-sphingomyelin (C5-DMB-sphingomyelin) 81

Bodipy Fl C5-succinimidyl Ester 83

Bodipy TR Ceramide 85

Bo-pro 1 87

Bo-pro 3 89

4-bromomethyl-6,7-dimethoxycoumarin 91

5-(bromomethyl)fluorescein 93

4-bromomethyl-7-methoxycoumarin 95

Calcein Blue Am 101

5-carboxy-2',7'-dichlorofluorescein 102

6-carboxy-2',7 '-dichlorofluorescein 104

5-carboxy-2',7'-dichlorofluorescein Diacetate 106

6-carboxy-2',7'-dichlorofluorescein Diacetate 108

5-carboxyfluorescein 110

6-carboxyfluorescein 114

5-carboxyfluorescein Diacetate 119

6-carboxyfluorescein Diacetate 121

5-carboxyfluorescein Succinimidyl Ester 125

6-carboxyfluorescein Succinimidyl Ester 129

5-carboxynaphthofluorescein 132

6-carboxynaphthofluorescein 134

Cascade Blue Acetyl Azide Trisodium Salt 136

Cascade Blue Hydrazide Trisodium Salt 138

3-cyano-7-ethoxycoumarin (7-ethoxycoumarin-3-carbonitrile) 139

3-cyano-7-hydroxycoumarin (3-cyanoumbelliferone) 141

4',6-diamidino-2-phenylindole Dihydrochloride (DAPI) 145

7-diethylaminocoumarin-3-carbonyl Azide 148

7-diethylaminocoumarin-3-carboxylic Acid (DAC) (DEAC) 149

7-diethylaminocoumarin-3-carboxylic Acid Hydrazide (DCCH) 153

7-diethylaminocoumarin-3-carboxylic Acid Succinimidyl Ester (DEAC SE) 155

4-[4-(diethylamino)styryl]-n-methylpyridinium iodide (4-Di-2-ASP) 157

3,3'-DIETHYLOXACARBOCYANINE IODIDE (DiOC2 (3)) 160

3,3'-DIHEPTYLOXACARBOCYANINE IODIDE (DiOC7 (3)) 163

3,3'-DIHEXYLOXACARBOCYANINE IODIDE (DiOC6 (3)) 165

Dihydrorhodamine 123 (DHR 123) 169

Dihydrorhodamine 6g (DHR 6g) 173

6,7-dimethoxycoumarin-4-acetic Acid 175

7-dimethylaminocoumarin-4-acetic Acid (DMACA) 176

7-dimethylaminocoumarin-4-acetic Acid Succinimidyl Ester (DMACA SE) 178

7-dimethylamino-4-methylcoumarin-3-isothiocyanate (DACITC) 180

2-[4-(dimethylamino)styryl]-n-ethylpyridinium Iodide (DASPEi) 181

4-[4-(DIMETHYLAMINO)STYRYL]-N-METHYLPYRIDINIUM IODIDE (4-Di-1-ASP) (DASPMI) 183

3,3'-DIMETHYL-a-NAPHTHOXACARBOCYANINE IODIDE (JC-9) 186

3,3'-DIPENTYLOXACARBOCYANINE IODIDE (DiOC5 (3)) 187

3,3'-DIPROPYLTHIADICARBOCYANINE IODIDE (DiSC3 (5)) 189

Ethidium Bromide (homidium Bromide) 193

ETHIDIUM HOMODIMER-1 (EthD-1) 199

ETHIDIUM HOMODIMER-2 (EthD-2) 203

Fluorescein 205

Fluorescein Diacetate (FDA) 213

Fluoroscein-5-isothiocyanate (FITC) 219

Fluorescein-5-thiosemicarbazide 224

4-heptadecyl-7-hydroxycoumarin (4-heptadecylumbelliferone) 227

Hexidium Iodide 229

Hoechst 33258 231

Hoechst 33342 238

Hoechst 34580 244

7-hydroxycoumarin-3-carboxylic Acid (umbelliferone-3-carboxylic Acid) 246

7-hydroxycoumarin-3-carboxylic Acid Succinimidyl Ester 250

7-hydroxy-4-methylcoumarin-3-acetic Acid 252

8-hydroxypyrene-1,3,6-trisulfonic Acid Trisodium Salt (HPTS) (PYRANINE) 253

Jojo 1 263

Jo-pro 1 265

Lolo 1 267

Lysosensor Blue Dnd 167 269

Lysosensor Blue Dnd 192 271

Lysosensor Green Dnd 153 272

Lysosensor Green Dnd 189 273

Lysosensor Yellow/blue Dnd 160 (PDMPO) 275

MARINA BLUE (6,8-DIFLUORO-7-HYDROXY-4-METHYLCOUMARIN) (DiFMU) 277

7-methoxycoumarin-3-carbonyl Azide 280

7-methoxycoumarin-3-carboxylic Acid 281

7-methoxycoumarin-3-carboxylic Acid Succinimidyl Ester 285

8-methoxypyrene-1,3,6-trisulfonic Acid Trisodium Salt (mpts) 287

Nbd C6-ceramide 289

Nbd Methylhydrazine (MNBDH) 293

Nuclear Yellow (hoechst S 769121) 295

Oregon Green 488 (2',7'-difluorofluorescein) 297

Oregon Green 488 Cadaverine 300

Oregon Green 488 Carboxylic Acid 302

Oregon Green 514 Carboxylic Acid 304

Oregon Green 488 Carboxylic Acid Diacetate 306

Oregon Green 488 Carboxylic Acid Succinimidyl Ester 308

Oregon Green 514 Carboxylic Acid Succinimidyl Ester 310

Oregon Green 488 Maleimide 312

Pacific Blue (6,8-difluoro-7-hydroxycoumarin-3-carboxylic Acid) 315

Pacific Blue C5-maleimide 317

Pacific Blue Succinimidyl Ester 318

Popo 1 320

Popo 3 322

Po-pro 1 324

Po-pro 3 326

Propidium Iodide (pi) 328

1-pyrenebutanoic Acid Hydrazide (PBH) 334

1-pyrenebutanoic Acid Succinimidyl Ester 336

1-pyrenedecanoic Acid (PDA) 340

1-pyrenedodecanoic Acid (PDDA) 343

1-pyrenehexadecanoic Acid 346

1-pyrenehexanoic Acid (PHA) 348

1-pyrenesulfonyl Chloride 350

1,3,6,8-pyrenetetrasulfonic Acid Tetrasodium Salt 352

N-(1-pyrenyl)iodoacetamide 355

N-(1-pyrenyl)maleimide 357

Qsy 7 Carboxylic Acid Succinimidyl Ester 361

Qsy 9 Carboxylic Acid Succinimidyl Ester 364

Qsy 21 Carboxylic Acid Succinimidyl Ester 366

Redoxsensor Red CC- 1 369

Resazurin Sodium Salt (alamar Blue) 370

Rhodamine 6g (RH 6g) 373

Rhodamine 110 (RH 110) 380

Rhodamine 123 (RH 123) 384

5,5',6,6' -tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine Iodide (JC-1) 389

Tetramethylrhodamine Ethyl Ester Perchlorate (TMRE) 394

Tetramethylrhodamine Methyl Ester Perchlorate (TMRM) 396

To-pro 1 398

To-pro 3 400

To-pro 5 403

Toto 1 405

Toto 3 408

True Blue (true Blue Chloride) 411

Vita Blue 413

Yo-pro 1 415

Yo-pro 3 419

Yoyo 1 421

Yoyo 3 425

Appendix A Index of Cas Registry Numbers 427

Appendix B Index of Acridines 431

Appendix C Index of Anthracenes 433

Appendix D Index of Boron Co-ordination Compounds/dyes 435

Appendix E Index of Coumarins 437

Appendix F Index of Cyanines/styryls 439

Appendix G Index of Heterocycles 441

Appendix H Index of Pyrenes 443

Appendix I Index of Xanthenes 445

Über Autor(innen)

R. W. SABNIS, PhD, is a registered Patent Agent with U.S. Patent and Trademark Office (USPTO). Dr. Sabnis is one of the world’s foremost experts in dyes, inventing world’s first colored bubbles (non-staining) and color changing dye system with many applications. He has immensely contributed to color science and technology for the past 25 years, particularly, dyes for biomedicine, personal care products, health/beauty products, electronics (displays, OLEDs), inks, paints, plastics, textiles and toys/bubbles. He has over 200 publications which include books, book chapters, encyclopedia chapters, patents, reviews, papers, and symposia presentations. He is also an inventor of several US and international patents (issued/published). Dr. Sabnis is the recipient of Pfish Award, Perkin Innovation Award, Grand Innovation Award, Competitive Spirit Award and Best Doctoral Thesis Award. Dr. Sabnis is awarded the Gold Medal for “Outstanding service to the coloration industry” by the Society of Dyers and Colourists, Bradford, U.K. He has written two books on color chemistry, namely, Handbook of Biological Dyesand Stains and Handbook of Acid-Base Indicators.