Plant-Based Therapeutics, Volume 2

The Brassicaceae Family
2024
ISBN: 978-3-031-63680-6
Verlag: Springer Nature Switzerland

Buch, Englisch, 820 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 1414 g

For centuries, research has been conducted on the therapeutics of Brassicaceaeplants and their health-promoting effects. Cato the Elder (234-149 BCE) documented their properties in his work  and recommended using cabbage to compress wounds, swelling, burns, and bone dislocations. For arthritis, he recommended chopped raw cabbage mixed with coriander and cured cabbage mixed with vinegar and honey.

In a groundbreaking discovery in the 1990s, scientists at Johns Hopkins University isolated sulforaphane from broccoli, revealing its potent anticancer properties. This naturally occurring compound has proven highly effective, safe, and tolerable and holds immense promise as a chemoprevention agent. It has the potential to combat various cancers, including breast, prostate, gastrointestinal, melanoma, lung, brain, and bladder. But its potential does not stop there. It also shows promise in treating cardiovascular and neurodegenerative diseases and diabetes, offering hope for those affected.

The cancer-protecting properties ofare mediated through compounds that induce a variety of physiological processes, including antioxidant action, detoxifying enzymes, inducing apoptosis, and cell cycle regulation. Glucosinolate breakdown products can affect several stages of cancer development, including the inhibition of activation enzymes (phase I) and the induction of detoxification enzymes (phase II). Isothiocyanates and indole products formed from glucosinolates regulate cancer cell development by regulating target enzymes, controlling apoptosis, inhibiting angiogenesis, metastasis, and the migration of cancer cells, and blocking the cell cycle.

Sulforaphane, found in abundance in broccoli sprouts, plays a crucial role in upregulating the transcriptional activity of specific genes and restoring epigenetic alterations. This is particularly significant as it modifies epigenetic pathways by targeting histone deacetylases and DNA methyltransferases. These modifications, in turn, alter gene transcription and expression, particularly in the case of cancers. This intricate process of gene regulation is a fascinating study area, making broccoli sprouts a compelling component of the 'epigenetic diet.'

Sulforaphane induces the cytoprotective enzyme NQO1. The inducible expression of NQO1 is regulated principally through the Keap1-Nrf2-ARE signaling pathway. The activation of the Nrf2-Keap1 signaling pathway heralds the beneficial actions of drugs known to affect Nrf2 signaling, such as dimethyl fumarate, an FDA-approved treatment for multiple sclerosis, and bardoxolone methyl for chronic kidney disease. There is optimism that the overall strategies are moving forward. Sulforaphane-rich broccoli sprout extracts provide one avenue toward this end.

Zielgruppe

Research

Autoren/Hrsg.

Ross, Ivan A.

Fachgebiete

• Naturwissenschaften Agrarwissenschaften Agrarwissenschaften
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Komplementäre Medizin, Asiatische Medizin (TCM), Heilpraktiker
• Naturwissenschaften Biowissenschaften Botanik

Inhaltsverzeichnis

Ch01: The History of Brassicaceae Plants.- Ch-02: The Bioactive Components of Chemical Constituents of Brassicaceae.- Nutrigenomics and Metabolomics of the Bioactive Compounds.- ch-05: The Anticarcinogenic Properties of Vegetables.- ch-06: Neurodegenerative Diseases.- ch-07: Epigenetic Modulation by Isothiocyanates.- ch-08: Breast Cancer.- ch-09: Brain Cancer.- ch-10: Cancer of the Urinary Bladder.- ch-12: Prostate Cancer.- Ch13: Vegetables and Hypothyroidism.- ch14: Brassicaceae and Viral Diseases.- ch15:Melatonin in Plants and Animals.

Über Autor(innen)

Ivan A. Ross, Biologist (Ret'd), U.S. Food and Drug Administration (FDA), participated in planning and conducting toxicology research projects and related programs and policies to ensure they meet the needs of the United States of America's food programs and responsibilities. He also developed, validated, and documented state-of-the-art analytical methods for specific specimens, compounds, or classes of compounds as necessary for increased efficiency and assurance of accuracy. Dr. Ross has published several research articles; four reference books, Medicinal Plants of the World: , and Volume One of this series, Plant-Based Therapeutics, Volume One, .