Romand / Varela-Nieto Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear

1. Auflage 2003
ISBN: 978-0-08-049091-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 57, 490 Seiten, Web PDF

Reihe: Current Topics in Developmental Biology

Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike.* Scores of high-quality, full- color figures* Detailed schemes on the structure and timing of ear development* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology

Autoren/Hrsg.

Romand, Raymond

Varela-Nieto, Isabel

Inhaltsverzeichnis

1;Cover;1
2;Copyright Page;5
3;Contents;6
4;Contributors ;14
5;Foreword;16
6;Introduction;18
7;Chapter 1. Molecular Conservation and Novelties in Vertebrate Ear Development;22
7.1;I. Introduction;23
7.2;II. Overview of Ideas Related to Ear Evolution;25
7.3;III. Making the Ear: Implementing and Expanding Genes for Ear Morphogenesis;27
7.4;IV. Evolution of the Ear: Molecular Origin of Mechanosensory Cells Predates Formation of the Ear;32
7.5;V. Developmental Molecular Biology of Hair Cell and Sensory Neuron Formation;34
7.6;VI. Evolution of Sensory Neurons: Heterochronic Alteration of HLH Gene Regulation;43
7.7;VII. Guidance of Afferent Fibers: The Role of Hair Cells and Other Mechanisms Revisited;44
7.8;VIII. Survival of Afferents: Evolving a Novel Mechanism and Expanding it to Fit the Increasing Complexity of Ear Development;50
7.9;IX. Splitting Hair Cell and Neuron Populations: Coevolving Sensory Epithelia and Their Innervation;54
7.10;X. Summary and Conclusions: Evolving Developmental Mechanisms;55
7.11;Acknowledgments;56
7.12;References;56
8;Chapter 2. Use of Mouse Genetics for Studying Inner Ear Development;66
8.1;I. Introduction: The Genetic Revolution;67
8.2;II. Early Morphogenesis of the Inner Ear;71
8.3;III. Development of the Neuroepithelium;76
8.4;IV. Concluding Remarks;96
8.5;References;96
9;Chapter 3. Formation of the Outer and Middle Ear, Molecular Mechanisms;106
9.1;I. Introduction;106
9.2;II. Basic Anatomical and Embryological Overview;107
9.3;III. Genetic Determinants of Outer and Middle Ear Development;110
9.4;IV. Concluding Remarks;128
9.5;References;129
10;Chapter 4. Molecular Basis of Inner Ear Induction;136
10.1;I. Introduction;137
10.2;II. Inner Ear Induction in Fish;139
10.3;III. Inner Ear Induction in Amphibians;148
10.4;IV. Inner Ear Induction in Birds;149
10.5;V. Inner Ear Induction in Mammals;152
10.6;VI. Perspectives on Inner Ear Induction;156
10.7;VII. Conclusions;162
10.8;Acknowledgments;163
10.9;References;163
11;Chapter 5. Molecular Basis of Otic Commitment and Morphogenesis: A Role for Homeodomain-Containing Transcription Factors and Signaling Molecules;172
11.1;I. Introduction;173
11.2;II. Patterning of the Inner Ear Anlagen;173
11.3;III. Transcription Factors and Diffusible Signals: A Complex Network;183
11.4;IV. Patterning and Morphogenesis;186
11.5;V. Conclusions;191
11.6;Acknowledgments;192
11.7;References;192
12;Chapter 6. Growth Factors and Early Development of Otic Neurons: Interactions between Intrinsic and Extrinsic Signals;198
12.1;I. Introduction;199
12.2;II. Early Development of Cochlear (Auditory) and Vestibular Neurons;200
12.3;III. Extrinsic Factors in Inner Ear Neurogenesis: Fibroblast Growth Factor, Nerve Growth Factor, and Insulin-Like Growth Factor-1 Families of Growth Factors;208
12.4;IV. Conclusions;218
12.5;Acknowledgments;218
12.6;References;218
13;Chapter 7. Neurotrophic Factors during Inner Ear Development;228
13.1;I. Neurotrophic Factors;229
13.2;II. The Neurotrophin System;229
13.3;III. The Glial Cell Line–Derived Neurotrophic Factor Family;238
13.4;IV. Conclusions;240
13.5;Acknowledgment;240
13.6;References;240
14;Chapter 8. FGF Signaling in Ear Development and Innervation;246
14.1;I. Introduction;246
14.2;II. Fibroblast Growth Factor Signaling in Ear Development;253
14.3;III. Conclusions and Future Directions;272
14.4;Acknowledgments;273
14.5;References;273
15;Chapter 9. The Roles of Retinoic Acid during Inner Ear Development;282
15.1;I. Introduction;283
15.2;II. Metabolism of Retinoids and Their Receptors;284
15.3;III. Expression of Retinoic Acid Metabolic Enzymes and Receptors in the Developing Inner Ear;286
15.4;IV. Is Retinoic Acid Involved in Otic Placode Induction?;290
15.5;V. Retinoids as Morphogens during Early Embryogenesis;292
15.6;VI. Retinoic Acid and Patterning Genes during Inner Ear Development;299
15.7;VII. Retinoic Acid and Hair Cell Differentiation;301
15.8;VIII. Concluding Remarks;303
15.9;Acknowledgment;304
15.10;References;304
16;Chapter 10. Hair Cell Development in Higher Vertebrates;314
16.1;I. Morphogenesis of the Mammalian Inner Ear;315
16.2;II. Control of Hair Cell Differentiation by Specific Genes;315
16.3;III. Production and Regeneration of New Hair Cells in Mature Inner Ears;331
16.4;IV. Conclusion;333
16.5;Acknowledgments;336
16.6;References;336
17;Chapter 11. Cell Adhesion Molecules during Inner Ear and Hair Cell Development, Including Notch and Its Ligands;342
17.1;I. Introduction;343
17.2;II. Adhesion Molecules;344
17.3;III. Adhesion Molecules and Development of the Inner Ear;351
17.4;IV. Summary;366
17.5;Acknowledgments;367
17.6;References;367
18;Chapter 12. Genes Controlling the Development of the Zebrafish Inner Ear and Hair Cells;378
18.1;I. Introduction;379
18.2;II. General Course of Zebrafish Otic Development;380
18.3;III. Otic Induction;380
18.4;IV. Patterning of the Placode and Early Vesicle;388
18.5;V. Development of Sensory Epithelia;394
18.6;VI. Auditory and Vestibular Function;399
18.7;VII. Conclusions and Prospects;401
18.8;References;402
19;Chapter 13. Functional Development of Hair Cells;410
19.1;I. Introduction;411
19.2;II. Maturation of Function;411
19.3;III. Development of Mechanoelectrical Transduction;416
19.4;IV. Developmental Acquisition of Basolateral Ion Channels;427
19.5;V. Outer Hair Cell Electromotility;446
19.6;VI. Interactions between Developing Hair Cells and Innervating Nerve Fibers;448
19.7;VII. Summary and Concluding Remarks;454
19.8;Acknowledgments;455
19.9;References;455
20;Chapter 14. The Cell Cycle and the Development and Regeneration of Hair Cells;470
20.1;I. Introduction;470
20.2;II. The Cell Cycle and the Regulation of Cell Proliferation;471
20.3;III. Hair Cell Development and Regeneration;474
20.4;IV. Cell Cycle Events during Hair Cell Development;476
20.5;V. The Cell Cycle during Hair Cell Regeneration;480
20.6;VI. Conclusions;483
20.7;Acknowledgments;483
20.8;References;484
21;Index;488
22;Contents of Previous Volumes;504
23;Color Plate Section;512