Ridley / Peckham / Clark Cell Motility

From Molecules to Organisms
1. Auflage 2005
ISBN: 978-0-470-09409-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 364 Seiten, E-Book

Recent advances in molecular and biophysical techniques,particularly fluorescence and live cell imaging, arerevolutionizing the study of cell motility. New bioprobes not onlyreveal simple intracellular localization, but also contain detailsof post-translational modifications, conformational state andprotein-protein interactions. Coupling these insights withcomplementary advances in genetic and biochemical methods isenabling scientists to understand the processes involved in cellmotility - from molecular motors to cell movements in vivo in arange of organisms and cell types.
This book features landmark essays that provide an up to date andfascinating account of current research and concepts in cellmotility.These cover the roles of molecular motors that drivemovement and their interactions with the cytoskeleton as well asmembrane dynamics that allow cells to change shape and tomove.
Cell motility plays a key role in development - there are chapterson the genetics of cell migration, the regulation of contactrepulsion in growth cones, and the progression from cell migrationto cell-cell adhesion. Cell motility is directional - expertsdescribe the molecules that regulate chemotaxis, allowing cells tomigrate along pathways specified by chemical gradients. Finally,cell motility can be perturbed by mutation--metastasis occurs whencells lose their normal intercellular interactions and invade othertissue types. All these processes are regulated by signals from theenvironment, including other tissues in the body, and the variousmolecules that transmit and transduce these signals arediscussed.
This book is a 'must read' for cell biologists working in a varietyof fields, from development to wound healing, at all levels -post-doctoral fellows, post-graduate students and lab technicians.It is also stimulating reading for molecular and developmentalbiologists, biophysicists and biochemists.

Autoren/Hrsg.

Ridley, Anne

Peckham, Michelle

Clark, Peter J.

Inhaltsverzeichnis

Preface.
List of contributors.
1. Molecular mechanisms regulating actin filament dynamics atthe leading edge of motile cells (Thomas D. Pollard).
2. The Role of Talin and Myosin VII in Adhesion - A FERMConnection (Margaret A. Titus).
3. Do class I myosins exert their functions through regulationof actin dynamics? (Thierry Soldati and Claudia Kistler).
4. Ephrin regulated contact repulsion of growth cones (Lene K.Harbott, Daniel J. Marston and Catherine D. Nobes).
5. Interplay between the actin cytoskeleton, focal adhesions,and microtubules (Christoph Ballestrem, Natalia Magid, Julia Zonis,Michael Shtutman, and Alexander Bershadsky).
6. Initial Steps from cell migration to cell-cell adhesion(Jason S. Ehrlich,W. James Nelson and Marc D. H. Hansen).
7. Using bioprobes to follow protein dynamics in living cells(Mark R. Holt, Daniel Y.H. Soong, James Monypenny, Ian M. Dobbie,Daniel Zicha and Graham A. Dunn).
8. Actin Filament Assembly: The Search for a Barbed End (CraigF. Stovold, Stewart J. Sharp and Laura M. Machesky).
9. Role of WASP family proteins in cytoskeletal reorganizationand cell motility (Tadaomi Takenawa and Shiro Suetsugu).
10. Regulation and function of the small GTP-binding proteinARF6 in membrane dynamics (Thierry Dubois, Emma Colucci-Guyon,Florence Niedergang, Magali Prigent and Philippe Chavrier).
11. Chemotaxis of cancer cells during invasion and metastasis(John Condeelis, Xiaoyan Song, Jonathan M. Backer, Jeffrey Wyckoffand Jeffrey Segall).
12. Dynamin and cytoskeletal-dependent membrane processes (JamesD. Orth, Noah W. Gray, Heather M. Thompson and Mark A.McNiven).
13. Regulation of microtubule dynamics in migrating cells: a newrole for Rho GTPases (Torsten Wittmann and Clare M.Waterman-Storer).
14. Calpain regulation of cell migration (AnnaHuttenlocher).
15. Role of villin in the dynamics of actin microfilaments(Rafika Athman, Sylvie Robine and Daniel Louvard).
16. Scar, WASP and the Arp2/3 complex in dictyosteliummigration (Simone Blagg and Robert Insall).
17. Directional sensing: subcellular targeting of GPCRdownstream effectors during chemotaxis (Satoru Funamoto and RichardA. Firtel).
18. Cell crawling, cell behavior and biomechanics duringconvergence and extension (Ray Keller and Lance Davidson).
19. Regulation of cell migration in vitro and invivo (Donna J. Webb, Karen Donais, Shin-ichi Murase, HanneloreAsmussen and Alan F. Horwitz).
20. Genes that control cell migration during mouse development(Carmen Birchmeier).
Index.