Organofluorine Compounds in Biology and Medicine

Erscheinungsjahr 2015
ISBN: 978-0-444-53748-5
Verlag: Elsevier Science & Technology

Buch, Englisch, 330 Seiten, Format (B × H): 159 mm x 241 mm, Gewicht: 637 g

Organofluorine Compounds in Biology and Medicine covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area.

Zielgruppe

<p>This book suits a wide audience, including organic chemists, physical organic chemists, synthetic chemists, medicinal and pharmaceutical chemists, organometallic chemists, biologists, and graduate and post graduate students.</p>

Autoren/Hrsg.

Reddy, Prakash

Reddy, V Prakash

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Physik, Chemie, Biologie für Mediziner
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

1. Introduction: General aspects of organofluorine compounds2. C-F bond strengths3. Effect of the neighboring C-F bonds on the C-H bond dissociation energies4. Effect of fluorine on the acidity and basicity5. Effect of fluorine on the metabolic stability6. Effect of fluorine on the bioavailability7. Positron emission tomography (PET) tracers8. 19F NMR Spectroscopic techniques for probing biochemical mechanisms9. Summary and outlook

Über Autor(innen)

Reddy, V Prakash
Dr. Prakash Reddy is currently active in research and teaching at the Missouri University of Science and Technology. He has received his Ph.D. in organic chemistry from the Case Western Reserve University, Cleveland, Ohio, and M.Phil. from the University of Hyderabad, India. He was an Adjunct and Visiting Professor at nationally reputed universities prior to joining Missouri University of Science and Technology in 2000. He received the Golden Key National Honor Society award for teaching excellence at Case Western Reserve University, and was a NASA Faculty Fellow at Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA. He has research interests in synthetic, mechanistic, and biological organic chemistry, and has significantly contributed to the area of carbocations and electrophilic reactions, superacids, and organofluorine chemistry.