Rapoport / Schewe Processing and Turnover of Proteins and Organelles in the Cell

FEBS Federation of European Biochemical Societies: 12th Meeting, Dresden, 1978
1. Auflage 2014
ISBN: 978-1-4831-8852-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 192 Seiten, Web PDF

Processing and Turnover of Proteins and Organelles in the Cell is a collection of papers that tackles the problems of post-translational processes, along with the dynamics of cell components. The materials in the title are organized thematically. The text first presents articles dealing with post-translational processing, such as the mode of anchoring of sucrase-isomaltase to the small intestinal brush-border membrane and its biosynthetic implications, as well as the decay and restoring in succinate dehydrogenase. The next papers discuss topics related to the selective degradation of proteins, such as selective control of proteinase action in yeast cells and studies of the mechanism and selectivity of intracellular protein breakdown. The final set of papers covers the turnover of organelles, which includes biogenesis and turnover of peroxisomes, and the effect of oxygen on the synthesis of mitochondrial proteins in Saccharomyces cerevisiae. The book will be of great use to microbiologists and biochemists. Scientists from biological science disciplines will also benefit from the text.

Autoren/Hrsg.

Rapoport, S.

Schewe, T.

Inhaltsverzeichnis

1;Front Cover;1
2;Processing and Turnover of Proteins and Organelles in the Cell;4
3;Copyright Page;5
4;Table of Contents;6
5;PREFACE;8
6;SESSION I:
Post-translational Processing;10
6.1;CHAPTER 1. POST-TRANSLATIONAL PROCESSING OF ONCORNAVIRUS PROTEINS;12
6.1.1;I. Expression of the genetic information of oncornaviruses;12
6.1.2;II. Processing of the gag gene polypeptides;14
6.1.3;Ill. Discussion;16
6.1.4;IV. Acknowledgements;18
6.1.5;V. References;18
6.2;CHAPTER 2. SYNTHESIS AND PROCESSING OF MULTICOMPONENT PROTEINS;20
6.2.1;ABSTRACT;20
6.2.2;INTRODUCTION;20
6.2.3;"GAG" GENE PROTEINS;21
6.2.4;VITELLOGENIN;22
6.2.5;ACTH/LPH/ENDORPHIN PRECURSOR;25
6.2.6;SIGNIFICANCE OF MULTICOMPONENT PROTEINS;26
6.2.7;REFERENCES;28
6.3;CHAPTER 3. THE MODE OF ANCHORING OF SUCRASE-ISOMALTASE TO THE SMALL INTESTINAL BRUSH-BORDER MEMBRANE AND ITS BIOSYNTHETIC IMPLICATIONS;30
6.3.1;ABSTRACT;30
6.3.2;INTRODUCTION;30
6.3.3;RESULTS AND DISCUSSION;32
6.3.4;REFERENCES;36
6.3.5;ACKNOWLEDGEMENTS;37
6.4;CHAPTER 4. THE SYNTHESIS AND PROCESSING OF COLLAGEN PRECURSORS;38
6.4.1;1. INTRODUCTION;38
6.4.2;2. THE NATURE OF COLLAGEN AND PROCOLLAGEN;38
6.4.3;3. TRANSLATION OF PROCOLLAGEN mRNA;41
6.4.4;4. HYDROXYLATION AND GLYCOSYLATION REACTIONS;42
6.4.5;5. ASSEMBLY AND SECRETION OF PROCOLLAGEN;45
6.4.6;6. EXTRACELLULAR MODIFICATIONS;46
6.4.7;REFERENCES;48
6.5;CHAPTER 5. SYNTHESIS AND PROCESSING OF MILK PROTEINS;52
6.5.1;REFERENCES;60
6.6;CHAPTER 6. SYNTHESIS AND PROCESSING OF IMMUNOGLOBULINS;66
6.6.1;ABSTRACT;66
6.6.2;INTRODUCTION;67
6.6.3;IMMUNOGLOBULINS SYNTHESIZED IN DIFFERENT B-CELL SUBPOPULATIONS;68
6.6.4;MALIGNANT STATES OF B-CELL SUBPOPULATIONS;69
6.6.5;Ig-SYNTHESIS AND PROCESSING IN PLASMA CELLS;70
6.6.6;Ig-SYNTHESIS AND PROCESSING IN SMALL, RESTING B-CELLS;73
6.6.7;Ig-SYNTHESIS AND PROCESSING IN PRECURSOR B-CELLS;74
6.6.8;REFERENCES;75
6.7;CHAPTER 7. IRON SULFUR CENTERS, RECONSTITUTIVE CAPACITY: DECAY AND RESTORING IN SUCCINATE DEHYDROGENASE;80
6.7.1;TABLE 1. EFFECT OF RHODANESE ON THE CATALYTIC ASSAYS AND RECONSTITUTIVE CAPACITY OF SUCCINATE DEHYDROGENASE;82
6.7.2;TABLE 2. EFFECT OF SULFUR DONORS ON THE RECONSTITUTIVE CAPACITY OF SUCCINATE DEHYDROGENASE;83
6.7.3;TABLE 3. EFFECT OF RHODANESE ON PARTICULATE SUCCINATE DEHYDROGENASE;85
6.7.4;TABLE 4. EFFECT OF MERCURIALS ON CATALYTIC ACTIVITY AND EPR SIGNALS OF SDH;87
6.7.5;SUMMARY;89
6.7.6;ACKNOWLEDGMENT;89
6.7.7;REFERENCES;90
7;SESSION II:
Selective Degradation of Proteins;92
7.1;CHAPTER 8. METHODS FOR DETERMINING PROTEIN TURNOVER;94
7.1.1;ESTIMATES OF BREAKDOWN OF WHOLE TISSUE PROTEINS FROM DECAY CURVES;94
7.1.2;ESTIMATES OF BREAKDOWN FROM MEASUREMENTS OF SYNTHESIS AND GROWTH;97
7.1.3;REFERENCES;102
7.1.4;ACKNOWLEGEMENTS;103
7.2;CHAPTER 9. SELECTIVE CONTROL OF PROTEINASE ACTION IN YEAST CELLS;104
7.2.1;ABSTRACT;104
7.2.2;REFERENCES;109
7.3;CHAPTER 10. STUDIES OF THE MECHANISM AND SELECTIVITY OF INTRACELLULAR PROTEIN BREAKDOWN;112
7.3.1;REFERENCES;114
7.3.2;ACKNOWLEDGEMENT;115
7.4;CHAPTER 11. THE ROLE OF CATHEPSINS L AND H FROM RAT LIVER LYSOSOMES IN PROTEIN DEGRADATION;116
7.4.1;REFERENCES;123
8;SESSION III: Turnover of Organelles;126
8.1;CHAPTER 12. BIOGENESIS AND TURNOVER OF PEROXISOMES;128
8.1.1;CHEMICAL PATHWAY OF CATALASE BIOSYNTHESIS;128
8.1.2;INTRACELLULAR PATHWAY OF CATALASE BIOSYNTHESIS;130
8.1.3;REFERENCES;133
8.2;CHAPTER 13. EFFECT OF OXYGEN ON THE SYNTHESIS OF MITOCHONDRIAL PROTEINS IN SACCHAROMYCES CEREVISIAE;134
8.2.1;ABSTRACT;134
8.2.2;INTRODUCTION;134
8.2.3;RESULTS;134
8.2.4;REFERENCES;141
8.3;CHAPTER 14. DEGRADATIVE PROCESSES IN YEAST MITOCHONDRIA AND THEIR RELATION TO MITOCHONDRIAL BIOGENESIS;142
8.3.1;ABSTRACT;142
8.3.2;INTRODUCTION;142
8.3.3;RESULTS AND DISCUSSION;143
8.3.4;REFERENCES;150
8.4;CHAPTER 15. MITOCHONDRIAL PROTEIN DEGRADATION;152
8.4.1;EXPERIMENTS WITH MITOCHONDRIAL PREPARATIONS;153
8.4.2;RADIOAUTOGRAPHY EXPERIMENTS;155
8.4.3;IMMUNOCYTOCHEMICAL LOCATION OF CARBAMYL PHOSPHATE SYNTHETASE (CPS) FROM RAT LIVER;157
8.4.4;REFERENCES;161
8.5;CHAPTER 16.
DEGRADATION OF MITOCHONDRIA IN RETICULOCYTES;164
8.5.1;ABSTRACT;164
8.5.2;KEYWORDS;164
8.5.3;INTRODUCTION;165
8.5.4;RESULTS AND CONCLUSIONS;166
8.5.5;ACKNOWLEDGEMENTS;176
8.5.6;REFERENCES;176
8.6;CHAPTER 17.
SYNTHESIS AND TURNOVER OF THE HEPATIC PLASMA MEMBRANE;178
8.6.1;ABSTRACT;178
8.6.2;INTRODUCTION;178
8.6.3;REFERENCES;186
9;AUTHOR INDEX;188
10;SUBJECT INDEX;190