Overview
- Provides a unique and comprehensive overview on identified colorectal cancer subtypes
- Suggests directions for targeted therapy development
- Addresses the problem of therapy resistance and proposes potential solutions
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1110)
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About this book
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Recent years have increased significantly our understanding of the genetic alterations that can underlie CRC, but also unraveled the molecular heterogeneity of the disease. Although a simple correlation between genetic pathways, histopathological features and clinical outcome cannot be established, the heterogeneity of CRC is also an opportunity for the development of targeted therapeutic approaches, able to treat an individual tumor with higher efficiency and less toxic side effects. One CRC subtype is characterized by high mutation rates (MSI-H), DNA methylation changes (CIMP-H), mutation in the BRAF oncogene and occurrence of serrated adenomas in the proximal colon. Other groups prevail in the distal colon and consist of either adenomatous polyps with chromosomal aberrations (CIN) and WNT pathway activation, or carry frequent KRAS mutation and metabolic deregulation, or have strong mesenchymal andinfiltrative characteristics. Characterization of driver-mutation events in these CRC subgroups has led to the development of specific drugs targeting, for example, the MAPK pathway, but initial clinical trials have revealed unexpected response rates.
The collection of chapters in this volume address the biology of specific CRC subtypes and how these may be targeted to improve precision therapy and clinical benefit for the patients.
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
About the editor
Peter Jordan is the President of the National Institute of Health Dr. Ricardo Jorge Scientific Committee. His research group is dedicated to the study of cancer's molecular and cellular biology.
Bibliographic Information
Book Title: Targeted Therapy of Colorectal Cancer Subtypes
Editors: Peter Jordan
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-030-02771-1
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-030-02770-4Published: 30 January 2019
eBook ISBN: 978-3-030-02771-1Published: 08 January 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 150
Number of Illustrations: 9 illustrations in colour
Topics: Cancer Research, Human Genetics, Molecular Medicine, Biomedical Engineering/Biotechnology, Immunology