Overview
- Tumor microenvironment is involved in the control of tumor
- growth and progression
- Inflammatory cells play a crucial role in the control of
- tumor microenvironment characteristics
- A new therapeutic approach in the treatment of cancer is the modulation of the biological activity of these cellular components
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About this book
This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.
Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.
In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.
Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.
In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.
New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
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Keywords
Table of contents (5 chapters)
Authors and Affiliations
Bibliographic Information
Book Title: The Role of Microenvironment in the Control of Tumor Angiogenesis
Authors: Domenico Ribatti
DOI: https://doi.org/10.1007/978-3-319-27820-9
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-27818-6Published: 16 February 2016
Softcover ISBN: 978-3-319-80222-0Published: 30 March 2018
eBook ISBN: 978-3-319-27820-9Published: 09 February 2016
Edition Number: 1
Number of Pages: XI, 86
Number of Illustrations: 12 b/w illustrations, 16 illustrations in colour
Topics: Cancer Research, Oncology, Pathology, Pharmacotherapy