Xenotransplantation

Basic Research and Clinical Applications
1. Auflage 2002
ISBN: 978-0-89603-674-1
Verlag: Humana Press

Buch, Englisch, 270 Seiten, Format (B × H): 161 mm x 235 mm, Gewicht: 594 g

Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Platt, Jeffrey L

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Transplantationschirurgie
• Geisteswissenschaften Philosophie Angewandte Ethik & Soziale Verantwortung Medizinische Ethik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Ethik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1 Molecular and Cellular Hurdles to Xenotransplantation.- 2 Pathological Responses to Xenotransplantation.- 3 Natural Xenoreactive Antibodies.- 4 Specificity of Xenoreactive Natural Antibodies.- 5 Biophysical Properties of Xenoreactive Natural Antibodies.- 6 The Origin of Xenoreactive Natural Antibodies.- 7 Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies.- 8 The Complement Barrier to Xenotransplantation.- 9 Defects and Amplification of Costimulation Across the Species.- 10 Antibody-Dependent Effects on Cellular Immunity.- 11 Disordered Regulation of Coagulation and Platelet Activation in Xenotransplantation.- 12 Current Applications of Cellular Xenografts.