Autoimmunity

Methods and Protocols
Softcover Nachdruck of the original 2. Auflage 2012
ISBN: 978-1-4939-5637-1
Verlag: Humana Press

Buch, Englisch, Band 900, 504 Seiten, Previously published in hardcover, Format (B × H): 178 mm x 254 mm, Gewicht: 1325 g

Reihe: Methods in Molecular Biology

Continued refinement of wide-spread access to transgenic technology has allowed for new animal models have been developed that exhibit features of autoimmune disease have been developed that exhibit features of autoimmune disease. The second edition of Autoimmunity: Methods and Protocols researchers in the field detail many of the most up-to-date methods which are now commonly used to study autoimmunity. The first half the book focuses on methods and protocols used to assess immunological and biochemical pathways of diseases pathogenesis in human subjects. While the second half investigates treatment of inflammatory arthritis, experimental allergic encephalomyelitis (EAE), IDDM, scleroderma, and uveitis in animal models and assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases. Written in the highly successful Methods in Molecular Biology(tm) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

 

  

Through and intuitive, Autoimmunity: Methods and Protocols, Second Edition seeks to aid scientists in the autoimmunity field to extract new meaning of old models and developing new ones.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Perl, Andras

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin

Inhaltsverzeichnis

Pathogenesis and Spectrum of Autoimmunity.-Mapping Susceptibility Gene in Systemic Lupus Erythematosus.-Methods and Protocols to study T Cell Signaling Abnormalities in Human Systemic Lupus Erythematosus.-Assessment of Mitochondrial Dysfunction in Lymphocytes of Patients with Systemic Lupus Erythematosus.-The Role of Endocytic Recycling in Autoimmunity.-Multi-Parameter Flow Cytometry and Bioanalytics for B Cell Profiling in Systemic Lupus Erythematosus.-Experimental Use of Mouse Models of Systemic Lupus Erythematosus.-Murine Models of Lupus Induced By Hypomethlated T Cell (DNA hypomethylation and lupus).-Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity.-Analysis of Renal Mononuclear Phagocytes in Murine Models of SLE.-A Murine Autoimmune Model of Rheumatoid Arthritis and Systemic Lupus Erythematosus Associated with Deregulated Production of IL-17 and IL-21.-The Parent-into-F1 Murine Model in the Study of Lupus-like Autoimmunity and CD8 Cytotoxic T Lymphocyte Function.-Genetic Approach to Study Lupus Glomerulonephritis.-Animal Models of Primary Biliary Cirrhosis:  Materials and Methods.-Modeling Innate Immunity in Murine Skin: Utilization of Subcutaneous Osmotic Pumps for Inflammatory and Fibrotic Skin Disease.-Flow Cytometric Identification of Fibrocytes in Scleroderma Lung Disease.-Oxidative Stress and Beta Cell Dysfunction.-Experimental Autoimmune Encephalomyelitis.-Mouse Models of Multiple Sclerosis:  Experimental Autoimmune Encephalomyelitis and Theiler’s Virus-Induced Demyelinating Disease.-Pathorgenesis of Multiple Sclerosis What Can we Learn from the Cuprizone Model.-Assessing Inflammatory Disease at Mucosal Surfaces in Murine Genetic Models.-Rodent Models of Experimental Autoimmune Uveitis (EAU).-Tolerance Induction via B-cell Delivered Gene Therapy.