Perez-Lloret Clinical Trials In Parkinson's Disease

1. Auflage 2021
ISBN: 978-1-0716-0912-5
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 160, 396 Seiten, eBook

Reihe: Neuromethods

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center.
Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.   

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Perez-Lloret, Santiago

Inhaltsverzeichnis

Series Preface…Dedication…Preface…Table of Contents…Contributing Authors…
Part I Preclinical Models of Parkinson’s Disease
1. Toxin-Based Rodent Models of Parkinson’s DiseaseM. Angela Cenci Nilsson and Véronique Sgambato
2. Assessment of Non-Motor Symptoms in Rodent Models of Parkinson’s DiseaseFrancesca Rossi, Manolo Carta, and Elisabetta Tronci
3. Genetic Models of Parkinson’s Disease Philippe Kachidian and Paolo Gubellini
Part II Clinical Trials for Motor Symptoms in Parkinson’s Disease
4. A Review of Randomized Phase III Pharmacological Clinical Trials for Motor Symptoms in Parkinson’s Disease Patients and Quality of Evidence RecommendationsMónica M. Kurtis, Carmen Rodriguez-Blazquez, and Isabel Pareés
5. Clinical Trials for Motor Complications in Parkinson’s DiseaseTiago A. Mestre, Joaquim J. Ferreira, and Olivier Rascol
6. Clinical Trials for Gait Disorders in Parkinson’s DiseaseZuzana Kosutzka, Urban M. Fietzek, and Peter Valkovic
7.  Clinical Trials for Disease Modifying Agents in Parkinson’s DiseaseOrlando Artavia and Lana Chahine
8. Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson’s DiseaseSantiago Perez-Lloret, James A.G. Crispo, Maria Veronica Rey, Donald Mattison, and Daniel Krewski
Part III Clinical Trials for Non-Motor Symptoms in Parkinson’s Disease
9. Clinical Trials for Cognitive Impairment and Dementia in Parkinson’s DiseaseBrandon Barton
10. Clinical Trials for Depression, Anxiety, Fatigue, and Apathy in Parkinson’s DiseaseMatej Skorvanek and Marek Balaz
11. Clinical Trials for Sleep Disorders and Daytime Somnolence in Parkinson’s DiseaseMarissa N. Dean and Amy W. Amara
12. Clinical Trials on Management of Pain in Parkinson’s DiseaseAzman Aris, Raquel Taddei, Alexandra Rizos, Anna Sauerbier, and K. Ray Chaudhuri
13. Clinical Trials for Orthostatic Hypotension in Parkinson’s Disease and Other Synucleinopathies Jose-Alberto Palma and Horacio Kaufmann
14. Clinical Trials for Erectile Dysfunction in Parkinson's DiseaseShen-Yang Lim, Ai Huey Tan, and Mathis Grossmann
15. Clinical Trials for Constipation in Parkinson’s DiseasePatricio Millar Vernetti
Subject Index List…