Pavlath Myogenesis

1. Auflage 2011
ISBN: 978-0-12-385941-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 96, 360 Seiten, Web PDF

Reihe: Current Topics in Developmental Biology

Myogenesis is the formation of muscular tissue, in particular during embryonic development. This new volume in the 'Current topics in Developmental Biology' series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis. With an international team of authors, this volume is a must-have addition for researchers and students alike. - This new volume in the 'Current topics in Developmental Biology' series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis - With an international team of authors, this volume is a must-have addition for researchers and students alike

Autoren/Hrsg.

Pavlath, Grace

Inhaltsverzeichnis

1;Front Cover;1
2;Myogenesis;2
3;Copyright;5
4;Contents;6
5;Contributors;10
6;Preface;14
7;Chapter 1: Origin of Vertebrate Limb Muscle;16
7.1;1. Introduction;17
7.2;2. Myogenesis Overview;17
7.3;3. Expression Analyses of Pax3/7 and MRF Transcription Factors;22
7.4;4. Functional Analysis of Pax3/7 and MRF Transcription Factors;26
7.5;5. Cre-Mediated Lineage and Ablation Analyses of PAX3, PAX7, and MRF+ Cells;32
7.6;6. Molecular Signals Distinguishing Between Different Phases of Myogenesis;37
7.7;7. Current Model of Myogenesis;39
7.8;Acknowledgments;41
7.9;References;42
8;Chapter 2: Developmental Origins of Fusion-Negative Rhabdomyosarcomas;48
8.1;1. Introduction;49
8.2;2. Mutations Seen in Fusion-Negative RMS;50
8.3;3. Cell of Origin of RMS;59
8.4;4. Tumor Phenotype and Cancer Stem Cells;63
8.5;References;65
9;Chapter 3: Sculpting Chromatin Beyond the Double Helix;72
9.1;1. Introduction;73
9.2;2. Satellite Cells;73
9.3;3. Repressing Muscle Gene Expression:Skeletal Muscle Developmental Regulatorsand Polycomb Proteins in Embryonic Stem(ES) and Nonmuscle Cells;74
9.4;4. Sculpting Chromatin for Transcription in Skeletal Muscle Cells;76
9.5;5. Conclusions;87
9.6;Acknowledgments;87
9.7;References;87
10;Chapter 4: NF-kappaB Signaling in Skeletal Muscle Health and Disease;100
10.1;1. Introduction;101
10.2;2. The NF-kappaB Family and Signaling Pathway Activation;102
10.3;3. Classical NF-kappaB Signaling;104
10.4;4. Regulation of NF-kappaB in Skeletal Myogenesis;107
10.5;5. Alternative NF-kappaB Signaling During Muscle Differentiation;110
10.6;6. NF-kappaB Function in Postnatal Skeletal Muscle Development;111
10.7;7. Regulation of NF-kappaB in Skeletal Muscle Adaptations;112
10.8;8. NF-kappaB Involvement in Skeletal Muscle Disorders;115
10.9;9. NF-kappaB Therapeutics;123
10.10;10. Concluding Remarks;126
10.11;Acknowledgments;126
10.12;References;126
11;Chapter 5: Blood Vessels and the Satellite Cell Niche;136
11.1;1. Introduction;137
11.2;2. Satellite Cell Proximity to Blood Vessel;138
11.3;3. Angiogenesis, Myogenesis, and the Regulation of Muscle Homeostasis;139
11.4;4. The Amplifying/Differentiating Niche: Role of ECs and Surrounding Stromal Cells;141
11.5;5. The Quiescence Niche: Role of Periendothelial Cells;143
11.6;6. Conclusions and Few Questions;146
11.7;References;149
12;Chapter 6: Nonmyogenic Cells in Skeletal Muscle Regeneration;154
12.1;1. Introduction;155
12.2;2. Accessory Cells in Skeletal Muscle Regeneration;156
12.3;3. Accessory Cells in Regeneration: A Mechanism Common to Multiple Tissues;158
12.4;4. Primary and Accessory Cell Communication;159
12.5;5. Development Versus Adult Regeneration;160
12.6;6. Regulation of Acute Muscle Regeneration and Repair by Immune Cells;161
12.7;7. MSCs and Tissue Regeneration;167
12.8;8. Conclusion;172
12.9;References;173
13;Chapter 7: Cellular and Molecular Mechanisms Regulating Fibrosis in Skeletal Muscle Repair and Disease;182
13.1;1. Introduction;183
13.2;2. Muscle Tissue Regeneration: To Repair or Pathologically Scar;185
13.3;3. Fibrosis Development in Dystrophic Muscle by the TGFbeta Family of Growth Factors;188
13.4;4. From Muscle Injury to the Chronic Inflammatory Response and Pathological Muscle Fibrosis;193
13.5;5. Alteration of the ECM Proteolytic Environment Leads to Fibrosis Development in Dystrophic Muscle;199
13.6;6. Age-Associated Changes in Muscle Function and Fibrosis;204
13.7;7. Concluding Remarks;209
13.8;Acknowledgments;210
13.9;References;210
14;Chapter 8: Ferlin Proteins in Myoblast Fusion and Muscle Growth;218
14.1;1. Introduction;219
14.2;2. Ferlin Expression and Localization and Interacting Proteins in Muscle;226
14.3;3. Cytoskeletal Rearrangement in Myogenesis;229
14.4;4. Ferlin Proteins in Cytoskeletal Rearrangements During Myogenesis;233
14.5;5. Ferlin Proteins Participate in Muscle Damage Repair;236
14.6;6. Concluding Remarks;238
14.7;Acknowledgments;239
14.8;References;239
15;Chapter 9: Circadian Rhythms, the Molecular Clock, and Skeletal Muscle;246
15.1;1. Introduction;247
15.2;2. Characteristics of Oscillating Systems;248
15.3;3. Environmental Influence on Endogenous Oscillators;252
15.4;4. Organization of the Circadian System;257
15.5;5. The Organization of the Mammalian Molecular Clock;258
15.6;6. The Molecular Clock in Skeletal Muscle;269
15.7;7. Summary;277
15.8;References;277
16;Chapter 10: Regulation of Nucleocytoplasmic Transport in Skeletal Muscle;288
16.1;1. Introduction;289
16.2;2. Nuclear Envelope;290
16.3;3. Nuclear Pore Complexes;291
16.4;4. Nuclear Import Pathways;293
16.5;5. Identifying Classical Nuclear Import-Dependent Cargoes;302
16.6;6. Remodeling of the Nuclear Transport Machinery;304
16.7;7. Challenges in Studying Nucleocytoplasmic Transport in Multinucleated Cells;306
16.8;8. Summary;308
16.9;Acknowledgments;308
16.10;References;308
17;Index;318
18;Color Plates;360