Paoletti / Kritchevsky Advances in Lipid Research

1. Auflage 2014
ISBN: 978-1-4832-2441-1
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 2, 512 Seiten, Web PDF

Reihe: Advances in Lipid Research

Advances in Lipid Research, Volume 2 provides a discussion of theories of triglyceride structure and presents a provocative comparison of in vitro versus in vivo lipid biosynthesis. This book covers brain phosphoinositide research, synthesis of phosphoglycerides, and the chemistry of lapoamino acids and phosphatidylglycerols. Organized into eight chapters, this volume begins with an overview of the procedure for calculating the percentages of the individual triglycerides as well as for triglyceride families. This text then examines the complex field of bacterial lipids. Other chapters consider the two aspects of the relationship between lipid metabolism and atherosclerosis. This book discusses as well the lipolytic and esterolytic activity of various tissues in connection with lipid transport and its relevancy to the development of atherosclerosis. The final chapter deals with the methods best adopted for in vitro and in vivo investigations of lipid biosynthesis. This book is a valuable resource for phospholipid chemists, biochemists, and scientists.

Autoren/Hrsg.

Paoletti, Rodolfo

Kritchevsky, David

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Lipid Research;4
3;Copyright Page;5
4;Table of Contents;10
5;CONTRIBUTORS TO THIS VOLUME;6
6;PREFACE;8
7;Chapter 1. Triglyceride Structure
;14
7.1;I. General;14
7.2;II. The 1,3 Random, 2 Random Distribution Hypothesis;15
7.3;III. The Validity of the 1,3 Random, 2 Random Distribution Hypothesis;19
7.4;IV. Mechanisms;23
7.5;References;29
8;Chapter 2. Bacterial Lipids;30
8.1;I. Introduction;30
8.2;II. Lipid Composition of Whole Cells;31
8.3;III. Intracellular Distribution of Lipids;65
8.4;IV. Biosynthesis of Lipid Components;82
8.5;References;97
9;Chapter 3. Phosphatidylglycerols and Lipoamino Acids;104
9.1;I. General Introduction;104
9.2;II. Phosphatidylglycerols;106
9.3;III. Lipoamino Acids;129
9.4;References;135
10;Chapter 4. The Brain Phosphoinositides;140
10.1;I. Introduction;140
10.2;II. Methods of Separation and Analysis;142
10.3;III. Chemistry of the Brain Inositides;148
10.4;IV. Enzymatic Breakdown;158
10.5;V. Biosynthesis;161
10.6;VI. Physiological Significance of Brain Inositides;169
10.7;References;176
11;Chapter 5. The Synthesis of Phosphoglycerides and Some Biochemical Applications;180
11.1;I. Introduction;181
11.2;II. Synthesis of Phosphatidylcholine;182
11.3;III. Synthesis of Phosphatidylethanolamine;196
11.4;IV. Synthesis of Phosphatidylserine;206
11.5;V. Synthesis of Miscellaneous Types of Phosphoglycerides and Derivatives;211
11.6;VI. Application of Synthetic Phosphoglycerides in Biochemical Problems;224
11.7;VII. Concluding Comments;241
11.8;References;242
12;Chapter 6. The Lipolytic and Esterolytic Activity of Blood and Tissues and Problems of Atherosclerosis;248
12.1;I. Introduction;248
12.2;II. Mast Cells, Lipid Transport, and Atherosclerosis;249
12.3;III. Effects of Protamine Sulfate Administration;253
12.4;IV. Some Observations on the Clearing Factor and Human Atherosclerosis;256
12.5;V. The Relationship between Lipoprotein Lipase, Postherapin Esterase, and Other "Clearing Factor Enzymes";267
12.6;VI. Lipolytic and Esterolytic Activity of Tissues;271
12.7;VII. Concluding Remarks;296
12.8;References;297
13;Chapter 7. Evaluation of Drugs Active against Experimental Atherosclerosis;308
13.1;I. Introduction;309
13.2;II. Experimental Atherosclerosis;311
13.3;III. Cholesterol Synthesis Inhibitors;341
13.4;IV. Acceleration of Cholesterol Degradation and Excretion;353
13.5;V. Sterols Related to Cholesterol;356
13.6;VI. Estrogens and Related Compounds;364
13.7;VII. Androgens and Related Compounds;377
13.8;VIII. Thyroid Hormones and Analogs;383
13.9;IX. Adrenal and Pituitary Hormones;398
13.10;X. Hypotensive Agents;409
13.11;XI Vitamins and Atherogenesis;412
13.12;XII. Unsaturated Fatty Acids;414
13.13;XIII. Lipoprotein Lipase and Heparin;419
13.14;XIV. Thrombosis, Fibrinolysis, and Anticoagulation;421
13.15;XV. Conclusions;429
13.16;References;430
14;Chapter 8. Comparative Evaluation of Lipid Biosynthesis in Vitro and in Vivo;460
14.1;I. Introduction;460
14.2;II. Study of Precursors;462
14.3;III. The Enzymatic Systems and the Mechanisms of Synthesis;463
14.4;IV. Localization of Synthesis;468
14.5;V. The Qualitative and Quantitative Regulation of Fatty Acid Synthesis;470
14.6;VI. Conclusion;472
14.7;References;472
15;AUTHOR INDEX;474
16;SUBJECT INDEX;504