Paoletti / Kritchevsky Advances in Lipid Research

1. Auflage 2014
ISBN: 978-1-4832-1542-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 21, 504 Seiten, Web PDF

Reihe: Advances in Lipid Research

Advances in Lipid Research, Volume 21 covers several significant and emerging areas in lipid metabolism, including apolipoprotein metabolism and leukotrienes. This book discusses the role of fat in the functioning of the immune system. Organized into eight chapters, this volume begins with an overview of the metabolism of apolipoprotein B, which is the principal protein of chylomicrons, very low density, and low density lipoprotein. This text then describes the metabolism, biosynthesis, and pharmacology of leukotrienes. Other chapters consider the relation of lipids to immunology and explain the roles played by lipids in the structure and function of yeast membrane. This book discusses as well the general importance in the plant kingdom and the place of some carotenoids in human biology. The final chapter deals with the influence of proteins on configuration and function of reconstituted lipid membranes. This book is a valuable resource for biologists, chemists, biochemists, scientists, and research workers.

Autoren/Hrsg.

Paoletti, Rodolfo

Kritchevsky, David

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Lipid Research;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;10
6;PREFACE;12
7;Chapter 1. Apolipoprotein B and Lipoprotein Metabolism;14
7.1;I. Introduction;14
7.2;II. Characterization of ApoB;15
7.3;III. Metabolism of ApoB in Lipoproteins;29
7.4;IV. Conclusions;51
7.5;ACKNOWLEDGMENTS;52
7.6;References;52
8;Chapter 2. Leukotrienes: Biosynthesis, Metabolism, and Analysis;60
8.1;I. Introduction;60
8.2;II. Mechanism of Leukotriene Biosynthesis;62
8.3;III. Metabolism of Leukotrienes;69
8.4;IV. Other Transformations of 5-Lipoxygenase;71
8.5;V. Leukotrienes Derived from 15-Lipoxygenase;74
8.6;VI. Control of Leukotriene Biosynthesis;76
8.7;VII. Analysis of Leukotrienes and Other Lipoxygenase Products;79
8.8;VIII. Concluding Remarks;85
8.9;References;85
9;Chapter 3. Pharmacology of the Leukotrienes;92
9.1;I. Slow-Reacting Substance of Anaphylaxis and Leukotrienes;92
9.2;II. Nomenclature of Leukotrienes;93
9.3;III. Leukotrienes and SRS-A Release;95
9.4;IV. Pharmacological Activities of Leukotrienes;96
9.5;V. Leukotrienes in Inflammatory Reactions;105
9.6;VI. Pharmacological Control of Leukotriene Synthesis;106
9.7;ACKNOWLEDGMENT;109
9.8;References;109
10;Chapter 4. Dietary Fat, Eicosanoids, and Immunity;116
10.1;I. Introduction;116
10.2;II. The Immune System and the Eicosanoids;118
10.3;III. Dietary Fat and the Immune Responses;134
10.4;IV. Conclusions;149
10.5;ACKNOWLEDGMENTS;152
10.6;References;152
11;Chapter 5. Gastrointestinal Digestion and Absorption of Lipid;156
11.1;I. Introduction;156
11.2;II. General Aspects of Intestinal Lipid Digestion and Absorption;157
11.3;III. Permeation of the Digested Fat into the Enterocyte;160
11.4;IV. The Intracellular Metabolism of the Absorbed Lipid;161
11.5;V. The Intracellular Assembly of Intestinal Lipoproteins;166
11.6;VI. Factors Affecting the Intestinal Chylomicron Secretion;176
11.7;VII. Regional Difference in Lymphatic Lipid Transport;182
11.8;VIII. Portal Transport of Long-Chain Fatty Acids;182
11.9;IX. Effect of Hormones on Intestinal Lipid Transport;183
11.10;X. Essential Fatty Acid-Deficient Rat;183
11.11;XI. Pluronic L-81 and Intestinal Lipid Transport;184
11.12;XII. Advances in the Past Two Decades;188
11.13;ACKNOWLEDGMENTS;191
11.14;References;192
12;Chapter 6. Lipids in the Structure and Function of Yeast Membrane;200
12.1;I. Introduction;200
12.2;II. Lipid Composition;202
12.3;III. Subcellular Localization;202
12.4;IV. Organization of Lipids;204
12.5;V. Factors that Influence Yeast Lipids;205
12.6;VI. Methods Employed to Alter Lipid Composition;213
12.7;VII. Lipids in Various Functions of Yeast;224
12.8;VIII. Lipids in the Structure of Yeast Membrane;241
12.9;IX. Conclusion;243
12.10;ACKNOWLEDGMENTS;244
12.11;References;244
13;Chapter 7. The in Vitro Biosynthesis of Carotenoids;256
13.1;I. Introduction;256
13.2;II. Structure and Nomenclature;257
13.3;III. Biosynthesis;258
13.4;IV. Preparation and Purification of Carotenogenic Cell Extracts;264
13.5;V. Assays of Carotenogenic Activities;268
13.6;VI. Properties of Carotenogenic Enzyme Preparations;271
13.7;VII. Regulation of Carotenoid Biosynthesis;281
13.8;VIII. Intracellular Distribution of Carotenogenic Enzymes;283
13.9;IX. Conclusions and Future Studies;285
13.10;ACKNOWLEDGMENTS;286
13.11;References;286
14;Chapter 8. Functional and Orientational Features of Protein Molecules in Reconstituted Lipid Membranes;294
14.1;I. Introduction;294
14.2;II. Methods Used for Reconstitution;299
14.3;III. Reconstitution of Transmembrane Integral Proteins and Complexes;320
14.4;IV. Reconstitution of Endoproteins;388
14.5;V. Proteoliposomes with More than One Reconstituted Protein or Complex;391
14.6;VI. In Vitro Assays of Incorporation of Mitochondrial Soluble Proteins into Liposomes;395
14.7;VII. General and Concluding Remarks;397
14.8;VIII. Appendix: Abbreviations;423
14.9;ACKNOWLEDGMENTS;424
14.10;References;424
15;Author Index;442
16;Subject Index;484
17;CONTENTS OF PREVIOUS VOLUMES;500