Paoletti / Kritchevsky Advances in Lipid Research

1. Auflage 2014
ISBN: 978-1-4832-1536-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 14, 288 Seiten, Web PDF

Reihe: Advances in Lipid Research

Advances in Lipid Research, Volume 14 is a five-chapter text that covers other important aspects of lipid chemistry, including an enzyme controlling cholesterol biogenesis, fatty acid activation, and lipid synthesis. The first chapter concerns with the control of activity of ?-hydroxy-?-methylglutaryl coenzyme A reductase. The second chapter deals with the specificity, localization, and function of fatty acid activation. The third chapter describes the interaction between polyene antibiotics and sterols. This chapter specifically tackles some antibiotic activity to understand membrane function and in vivo hypolipidemic activity. The fourth chapter focuses on the lipids in plant cultures, while the fifth chapter looks into the methods of synthesis of acylglycerols and phosphoglycerides. This book will prove useful to lipid chemists, biochemists, and researchers.

Autoren/Hrsg.

Paoletti, Rodolfo

Kritchevsky, David

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Lipid
Research;4
3;Copyright Page;5
4;Table of Contents;6
5;LIST OF CONTRIBUTORS;10
6;PREFACE;12
7;CONTENTS OF PREVIOUS VOLUMES;14
8;Chapter 1. Regulation of
HMG–CoA Reductase;22
8.1;I. Introduction;23
8.2;II. Unique Role of HMG–CoA Reductase in Sterol
Biosynthesis;24
8.3;III. Distribution of
HMG–CoA Reductase;27
8.4;IV. Assay of HMG–CoA
Reductase Activity;28
8.5;V. Solubilized Mammalian Liver Microsomal HMG-CoA Reductase;30
8.6;VI. Diurnal Rhythm of Mammalian Liver HMG-CoA Reductase;36
8.7;VII. Developmental Pattern of Rat Liver HMG-CoA Reductase;47
8.8;VIII. Hormonal Effects on HMG-CoA Reductase;51
8.9;IX. Modulation of HMG-CoA Reductase Activity;60
8.10;X. Regulation of Mammalian HMG-CoA Reductase by Steroids;64
8.11;XI. Familial
Hypercholesterolemia;78
8.12;XII. Microbial HMG-CoA Reductases;83
8.13;XIII. Conclusion;88
8.14;References;90
9;Chapter 2. Fatty Acid Activation: Specificity, Localization,
and Function;96
9.1;I. Introduction;96
9.2;II. Assays for Acyl-CoA Synthetases;98
9.3;III. Reaction Mechanism;100
9.4;IV. Substrate Specificity of Acyl-CoA Synthetases;102
9.5;V. Subcellular Localization of Acyl-CoA Synthetases;121
9.6;VI. Organ Distribution of Acyl-CoA Synthetases;128
9.7;VII. Function and Regulation of Acyl-CoA Synthetases;132
9.8;Note Added in Proof;140
9.9;References;140
10;Chapter 3. Polyene
Antibiotic–Sterol Interaction;148
10.1;I. Introduction;148
10.2;II. Structures and Chemical Properties of Polyene Antibiotics;150
10.3;III. Biological Properties of Polyene Antibiotics;161
10.4;IV. Molecular Basis of Polyene Antibiotics—Interaction with Membrane Sterols;166
10.5;V. Polyene Antibiotics
in the Study of Membrane Structure–Function Relationships;174
10.6;VI. Concluding Remarks;187
10.7;References;187
11;Chapter 4. The Lipids of Plant Tissue Cultures;192
11.1;I. Introduction;192
11.2;II. The Plant Tissue Culture Technique;193
11.3;III. Total Lipids of Plant Tissue Cultures;201
11.4;IV. Fatty Acid Patterns of Lipids in Plant Tissue Cultures;207
11.5;V. Variables Affecting the Lipids of Plant Tissue Cultures;212
11.6;VI. Applications of Plant Tissue Cultures;217
11.7;VII. Summary and Conclusion;225
11.8;References;226
12;Chapter 5. Synthesis of Some Acylglycerols and Phosphoglycerides;234
12.1;I. Introduction;235
12.2;II. General Considerations;235
12.3;III. Racemic Acylglycerols;245
12.4;IV. Synthesis of Enantiomeric Acylglycerols;256
12.5;V. Synthesis of Phosphoglycerides;261
12.6;VI. Summary;267
12.7;References;267
13;AUTHOR INDEX;270
14;SUBJECT INDEX;284