Paoletti / Kritchevsky Advances in Lipid Research

1. Auflage 2014
ISBN: 978-1-4832-1532-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 10, 404 Seiten, Web PDF

Reihe: Advances in Lipid Research

Advances in Lipid Research, Volume 10 is a six-chapter text that is devoted to several special areas of lipid research, including significant progress in established areas of interest in the field. The introductory chapter surveys the application of electron microscopic techniques to the analysis of plasma lipoproteins. The subsequent chapter deals with the possible modification of reticuloendothelial functions by lipids and the role of lipids in cellular, humoral, and immune responses. These topics are followed by discussions of the microsomal enzymes of sterol biosynthesis and the enzymatic synthesis and degradation of glycerol lipids, which contain ether bonds. The remaining chapters focus on lipid neurochemistry. These chapters specifically examine particular brain lipids, such as fatty acids, phospholipids, sphingolipids, galatosyl lipids, and sterols. A discussion of lipids of the entire nervous system and their variation with age is also included. This book will prove useful to lipids chemists, biochemists, and organic chemists.

Autoren/Hrsg.

Paoletti, Rodolfo

Kritchevsky, David

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Lipid Research;4
3;Copyright Page;5
4;Table of Contents;6
5;LIST OF CONTRIBUTORS;10
6;PREFACE;12
7;CONTENTS OF PREVIOUS VOLUMES;14
8;Chapter 1. Application of Electron Microscopy to the Study of Plasma Lipoprotein Structure;20
8.1;I. Introduction;20
8.2;II. Physical and Chemical Characterization of Plasma Lipoproteins;21
8.3;III. Various Techniques of Electron Microscopy Applied to
Investigation of Lipoprotein Structure;23
8.4;IV. Concluding Remarks;56
8.5;References;57
9;Chapter 2.
Employment of Lipids in the Measurement and Modification of Cellular, Humoral, and Immune Responses;62
9.1;I. Introduction;62
9.2;II. Problems Relative to the Evaluation of Reticuloendothelial Function;64
9.3;III. Employment of Lipids to Measure Reticuloendothelial Function in Vivo;65
9.4;IV. In Vitro Employment of Lipids for Evaluation of Cellular and
Humoral Events in Phagocytosis;67
9.5;V. Evaluation of Plasma Humoral Recognition Factor Activity in
Human Subjects;72
9.6;VI. Employment of Lipids to Depress Phagocytic Activity of the Reticuloendothelial System;77
9.7;VII. Employment of Lipids to Stimulate Phagocytic Activity of the Reticuloendothelial System;86
9.8;VIII. Modification of Endotoxin Responses by Lipids;91
9.9;IX. Role of Intravenous Lipids in Modifying Infectious Processes;95
9.10;X. Influence of Intravenously Administered Lipids on the Immune Response;97
9.11;XI. Influence of Intravenously Administered Lipids on Transplantation
Reactions;101
9.12;XII. Summary;104
9.13;References;105
10;Chapter 3.
Microsomal Enzymes of Sterol Biosynthesis;108
10.1;I. Introduction;108
10.2;II. Solubilization of Microsomal Enzymes;115
10.3;III. Other Aspects of Purification of Microsomal Enzymes;153
10.4;References;157
11;Chapter 4.
Brain Lipids;162
11.1;I. Introduction;163
11.2;II. Fatty Acids;164
11.3;III. Galactosyl Mono- and Diglycerides;172
11.4;IV. Phospholipids : Introduction;172
11.5;V. Sphingolipids;185
11.6;VI. Cholesterol, Methyl Sterols, Trace Isoprenoids, and Other Trace Lipids;204
11.7;VII. Myelin and Other Subcellular Fractions of the Brain;215
11.8;VIII. Effect of Undernutrition of Lipids of the Brain;217
11.9;IX. Lipids and the Developing Brain;221
11.10;X. Enzymes of Significance to Brain Lipids;225
11.11;XI. Proteolipids;225
11.12;XII. Lipids in Cell-Enriched Fractions of the Brain;226
11.13;XIII. Metabolic Diseases of the Brain;228
11.14;XIV. Summary and Conclusions;237
11.15;References;238
12;Chapter 5.
Enzymatic Systems That Synthesize and Degrade Glycerolipids Possessing Ether Bonds;252
12.1;I. Introduction;252
12.2;II. Nomenclature and Structural Formulas;254
12.3;III. Methods of Analysis;258
12.4;IV. Biosynthesis;260
12.5;V. Degradation;269
12.6;References;275
13;Chapter 6.
Lipids in the Nervous System of Different Species as a Function of Age: Brain, Spinal Cord, Peripheral Nerve, Purified Whole Cell Preparations, and Subcellular Particulates: Regulatory Mechanisms and Membrane Structure;280
13.1;I. Introduction;281
13.2;II. Assessment of Methods for Accurate, Precise, Quantitative Lipid
Analysis and the Reporting of Lipid Class Composition Data;282
13.3;III. Human Nervous System Lipid Composition Changes with Age;295
13.4;IV. Animal Nervous System Lipid Composition Changes with Age and
Comparison to Humans;311
13.5;V. Conclusions Derived from Studies of Lipid Composition of Isolated Whole Cell and Subcellular Particulate Preparations of the Nervous System;326
13.6;VI. Membrane Biosynthesis and the Regulatory Mechanisms of Lipid
Metabolism That Determine Membrane Lipid Class Composition;351
13.7;VII. Membrane Structure;362
13.8;References;369
14;AUTHOR INDEX;380
15;SUBJECT INDEX;399