Biochemical Pharmacology

1. Auflage 2012
ISBN: 978-0-470-17445-6
Verlag: John Wiley and Sons Ltd

Buch, Englisch, 428 Seiten, Format (B × H): 182 mm x 256 mm, Gewicht: 916 g

This book explains the biochemical principles of drug action, to students of biochemistry and related scientific disciplines. For each drug discussed, the authors provide the biochemical concepts needed to understand its function. They explain some of the experimental methods used to characterize drugs and their receptors, together with examples of the evidence that these methods provide. Clinical and physiological aspects are outlined where useful to appreciate the significance of a drug's action. Finally, the authors point out some of the questions that remain to be solved by future researchers. End-of-chapter exercises encourage self-evaluation and further reading. The text contains many illustrations that also are available to course instructors as PowerPoint slides.

Autoren/Hrsg.

Palmer, Michael

Chan, Alice

Honek, John F.

Dieckmann, Thorsten

Honek, John

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Preface

Acknowledgments

1 Introduction

1.1 Origin and preparation of drugs

1.2 Drugs and drug targets

1.3 Drug molecules may or may not resemble the physiological ligands of their receptors

1.4 Strategies of drug discovery and development

2 Pharmacodynamics

2.1 Molecular features of drug-receptor interaction

2.2 Theory of drug-receptor binding

2.3 Dose-effect relationships in signaling cascades

2.4 Potency and efficacy

2.5 Beneficial and toxic drug effects

2.6 Appendix

3 Pharmacokinetics

3.1 Anatomical barriers to drug transport

3.2 Solute transport across cell membranes

3.3 Drug application

3.4 Drug distribution

3.5 Drug elimination via the kidneys

3.6 Quantitative experimental methods in pharmacokinetics

4 Drug metabolism

4.1 Overview: Possible functional outcomes of drug metabolism

4.2 Phase I and phase II reactions

4.3 Cytochrome P450

4.4 Reductive drug metabolism

4.5 Conjugation reactions

4.6 Enzyme induction

4.7 Metabolism-related toxicity as a therapeutic target

5 G protein-coupled receptors

5.1 Overview

5.2 GPCR structure

5.3 Structural GPCR families

5.4 Activation of GPCRs

5.5 GPCR dimerization and oligomerization

5.6 G proteins

5.7 GPCR phosphorylation, endocytosis, and G protein independent signalling

5.8 Appendix

6 Pharmacology of cell excitation

6.1 Ions, pumps and channels

6.2 ATP-driven active ion transport

6.3 Voltage-gated channels and the action potential

6.4 Channels controlled by intracellular ligands

6.5 Transient receptor potential (TRP) channels

6.6 Voltage-gated channels of nerve cells as drug targets

6.7 Synaptic transmission

6.8 Pharmacology of individual transmitters

6.9 Appendix

7 Hormones

7.1 Hormone receptors

7.2 The hypothalamus and the pituitary gland

7.3 Thyroid gland hormones

7.4 Steroid hormones

7.5 Endocrine control of bone mineralization

8 Pharmacology of nitric oxide

8.1 Characterization of nitric oxide as a biological signaling molecule

8.2 Nitric oxide synthase and its isoforms

8.3 Biochemical mechanisms of NO signaling

8.4 The biological function of iNOS

8.5 NO-releasing drugs

8.6 NOS inhibitors

8.7 Phosphodiesterase inhibitors

9 Eicosanoid mediators and related drugs

9.1 Biosynthesis of eicosanoids

9.2 The cyclooxygenase reaction

9.3 Cyclooxygenase isoforms and inhibitors

9.4 Phospholipase A2 inhibitors

9.5 Derivatives of prostaglandin H2 and related drugs

9.6 Lipoxygenases, leukotrienes and related drugs

9.7 Eicosanoids synthesized by cytochrome P450

9.8 Endocannabinoids and related drugs

9.9 The role of poly-unsaturated fatty acids in eicosanoid signaling

10 Intermediate metabolism, diabetes and atherosclerosis

10.1 Hereditary enzyme defects

10.2 Gout

10.3 Diabetes mellitus

10.4 Atherosclerosis

11 Chemotherapy of infectious diseases

11.1 Pathogenic microbes: Diversity and selective toxicity

11.2 Pharmacokinetic considerations

11.3 Resistance to antimicrobials

11.4 Antibacterial chemotherapy

11.5 Chemotherapy of fungal infections

11.6 Chemotherapy of parasite infections

11.7 Antiviral chemotherapy

12 Tumor chemotherapy

12.1 Some principles of tumor biology

12.2 Cell type-specific anti-tumor drugs

12.3 Drugs that target specific oncoproteins

12.4 Cytotoxic anti-tumor drugs

13 Ribonucleic acids as drug targets and drugs

13.1 RNA as drug target

13.2 RNA as a therapeutic agent

14 Drug delivery

14.1 Improving intestinal drug absorption

14.2 Improving drug distribution

14.3 Targeted drug delivery

14.4 Kinetically controlled drug release

14.5 Controlling drug toxicity

14.6 Delivery of nucleic acids

15 Drug Discovery

15.1 Target Selection and Validation

15.2 Screening of Candidate Compounds

15.3 Computational Screening

15.4 Phenotypic Screening

15.5 Compound Acquisition

Answers to

Über Autor(innen)

Honek, John F.
John Honek, PhD, is Professor in the Department of Chemistry at the University of Waterloo, associate editor for Future Medicinal Chemistry and Biochemistry and Cell Biology, and serves on the editorial boards of BioMed Central Biochemistry, Current Medicinal Chemistry, and Letters in Drug Design and Discovery.

Palmer, Michael
Michael Palmer, MD, is Associate Professor in the Department of Chemistry at the University of Waterloo, Ontario, Canada, where he teaches courses on metabolism, biological membranes, and biochemical pharmacology.

Dieckmann, Thorsten
Thorsten Dieckmann, PhD, is Associate Professor in the Department of Chemistry at the University of Waterloo. He has written over forty articles, papers, abstracts, and presentations.

Michael Palmer, MD, is Associate Professor in the Department of Chemistry at the University of Waterloo, Ontario, Canada, where he teaches courses on metabolism, biological membranes, and biochemical pharmacology.

Alice Chan, MSc, is a reader demonstrator at the University of Calgary.

Thorsten Dieckmann, PhD, is Associate Professor in the Department of Chemistry at the University of Waterloo. He has written over forty articles, papers, abstracts, and presentations.

John Honek, PhD, is Professor in the Department of Chemistry at the University of Waterloo, associate editor for Future Medicinal Chemistry and Biochemistry and Cell Biology, and serves on the editorial boards of BioMed Central Biochemistry, Current Medicinal Chemistry, and Letters in Drug Design and Discovery.