Buch, Englisch, 176 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 295 g
Reihe: Springer Theses
Buch, Englisch, 176 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 295 g
Reihe: Springer Theses
ISBN: 978-3-642-43652-9
Verlag: Springer
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Biotechnologie: Mikrotechnologie, Nanobiotechnologie
- Naturwissenschaften Biowissenschaften Biowissenschaften DNA und Transgene Organismen
- Naturwissenschaften Physik Angewandte Physik Biophysik
- Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
Weitere Infos & Material
A Novel DNA Model.- Methods.- Finite Size Effects.- Structural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.
