Oestreich The Mizoroki-Heck Reaction

1. Auflage 2009
ISBN: 978-0-470-71606-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 608 Seiten, E-Book

Exploring the importance of Richard F. Heck's carbon couplingreaction, this book highlights the subject of the 2010 Nobel Prizein Chemistry for palladium-catalyzed cross couplings in organicsynthesis, and includes a foreword from Nobel Prize winner RichardF. Heck.
The Mizoroki-Heck reaction is a palladium-catalyzedcarbon-carbon bond forming process which is widely used inorganic and organometallic synthesis. It has seen increasing use inthe past decade as chemists look for strategies enabling thecontrolled construction of complex carbon skeletons. TheMizoroki-Heck Reaction is the first dedicated volume on thisimportant reaction, including topics on:
* mechanisms of the Mizoroki-Heck reaction
* intermolecular Mizoroki-Heck reactions
* focus on regioselectivity and product outcome in organicsynthesis
* waste-minimized Mizoroki-Heck reactions
* intramolecular Mizoroki-Heck reactions
* formation of heterocycles
* chelation-controlled Mizoroki-Heck reactions
* the Mizoroki-Heck reaction in domino processes
* oxidative heck-type reactions (Fujiwara-Moritanireactions)
* Mizoroki-Heck reactions with metals other than palladium
* ligand design for intermolecular asymmetric Mizoroki-Heckreactions
* intramolecular enantioselective Mizoroki-Heck reactions
* desymmetrizing Mizoroki-Heck reactions
* applications in combinatorial and solid phase syntheses, andthe development of modern solvent systems and reactiontechniques
* the asymmetric intramolecular Mizoroki-Heck reaction in naturalproduct total synthesis
Several chapters are devoted to asymmetric Heck reactions withparticular focus on the construction of otherwisedifficult-to-obtain sterically congested tertiary and quaternarycarbons. Industrial and academic applications are highlighted inthe final section. The Mizoroki-Heck Reaction will find aplace on the bookshelves of any organic or organometallicchemist.
"I am convinced that this book will rapidly become themost important reference text for research chemists in academia andindustry who seek orientation in the rapidly growing and -for the layman - confusing field described as the"'Mizoroki-Heck reaction'."(Synthesis, March 2010)

Autoren/Hrsg.

Oestreich, Martin

Inhaltsverzeichnis

Foreword by Professor Richard F. Heck
1 Mechanisms of the Mizoroki-Heck Reaction
Anny Jutand
2 Focus on Catalyst Development and Ligand Design
Irina P. Beletskaya and Andrei V. Cheprakov
3 Focus on Regioselectivity and Product Outcome in OrganicSynthesis
Peter Nilsson, Kristofer Olofsson and Mats Larhed
4 Waste-Minimized Mizoroki-Heck Reactions
Lukas Gooßen and KätheGooßen
5 Formation of Carbocycles
Axel B. Machotta and Martin Oestreich
6 Formation of Heterocycles
Thierry Muller and Stefan Bräse
7 Chelation-Controlled Mizoroki-Heck Reactions
Kenichiro Itami and Jun-ichi Yoshida
8 The Mizoroki-Heck Reaction in DominoProcesses
Lutz F. Tietze and Laura M. Levy
9 Oxidative Heck-Type Reactions (Fujiwara-MoritaniReactions)
Eric M. Ferreira, Haiming Zhang and Brian M. Stoltz
10 Mizoroki-Heck Reactions with Metals Other thanPalladium
Lutz Ackermann and Robert Born
11 Ligand Design for Intermolecular AsymmetricMizoroki-Heck Reactions
Anthony G. Coyne, Martin O. Fitzpatrick and Patrick J.Guiry
12 Intramolecular Enantioselective Mizoroki-HeckReactions
James T. Link and Carol K. Wada
13 Desymmetrizing Heck Reactions
Masakatsu Shibasaki and Takashi Ohshima
14 Combinatorial and Solid-Phase Syntheses
Thierry Muller and Stefan Bräse
15 Mizoroki-Heck Reactions: Modern Solvent Systems andReaction Techniques
Werner Bonrath, Ulla L´etinois, Thomas Netscher and JanSchütz
16 The Asymmetric Intramolecular Mizoroki-Heck Reactionin Natural Product Total Synthesis
Amy B. Dounay and Larry E. Overman

Über Autor(innen)

Martin Oestreich (born in 1971 in Pforzheim/Germany) iscurrently Professor of Organic Chemistry at the TechnischeUniversität Berlin. He received his diploma degree with PaulKnochel (Marburg, 1996) and his doctoral degree with Dieter Hoppe(Münster, 1999). After a two-year postdoctoral stint withLarry E. Overman (Irvine, 1999-2001), he completed his habilitationwith Reinhard Brückner (Freiburg, 2001-2005) and was appointedas Professor of Organic Chemistry at the WestfälischeWilhelms-Universität Münster (2006-2011). He also heldvisiting positions at Cardiff University in Wales (2005) and at TheAustralian National University in Canberra (2010).