A Picture is Worth a Thousand Tables

Graphics in Life Sciences
2012
ISBN: 978-1-4614-5328-4
Verlag: Springer US

Buch, Englisch, 429 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 846 g

This book is devoted to the graphics of patient data: good graphs enabling straight¬forward and intuitive interpretation, efficient creation, and straightforward interpretation. We focus on easy access to graphics of patient data: the intention is to show a large variety of graphs for different phases of drug development, together with a description of what the graph shows, what type of data it uses, and what options there are. The main aim is to provide inspiration in form of a “graphics cookbook.” Many graphs provide creative ideas about what can be done. The book is not intended to be technical. It introduces general principles of good visualization to make readers understand the concepts, but the main focus is on the creativity and usefulness: readers are enabled to browse through the book to get ideas of how their own data can be analyzed graphically.

For additional information visit Editor’s companion website: http://www.elmo.ch/doc/life-science-graphics/

Zielgruppe

Research

Autoren/Hrsg.

Oconnell, Michael

Krause, Andreas

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizinische Mathematik & Informatik

Inhaltsverzeichnis

Concepts and Principles of Clinical Data Graphics.- Graphics for Exploratory Analysis and Data Discovery in the Life Sciences.- Grables: Visual Displays That Combine the Best Attributes of Graphs and Tables.- The Use of Figures in Epidemiological Publications: A Survey of Current Practice and Consequent Recommendations.- Use of Graphics for Studies with Small Sample Sizes: A Simulated Case Study of an Early-Phase Asset for Treatment of Type 2 Diabetes Mellitus (T2DM).- Exploring Pharmacokinetic and Pharmacodynamic Data.- (Interactive) Graphics for Biomarker Assessment.- Graphical Displays for Biomarker Data.- Statistical Graphics in Clinical Oncology.- Efficient and Effective Review of Clinical Trial Data Safety Using Interactive Graphs and Tables.- Visualizing Dose-Response when the Signal to Noise Ratio is Low: The Bronchodilatory Response in Chronic Obstructive Pulmonary Disease.- Statistical Graphics in Late-Stage Drug Development.- Graphical Data Exploration in QT Model Building and Cardiovascular Drug Safety.- Data Visualization at the Individual Patient Level.- Graphics for Meta-Analysis.- Visualization of QT Data for Thorough QT Study Analysis and Review.- Graphics for Safety Analysis.- Cardiac Safety.- Data Visualization for Clinical Trials Data Management and Operations.- Post-Approval Uses of Clinical Data, Phase IV Data, and Sales & Marketing Data Visualizations.- Using Exploratory Visualization in the Analysis of Medical Product Safety in Observational Healthcare Data.

Über Autor(innen)

Andreas Krause

Andreas Krause has 20 years of experience in the pharmaceutical industry. Holding a PhD in statistics and econometrics, his areas of expertise include modeling and simulation, also known as pharmacometrics, biostatistics and bioinformatics. He is director and lead scientist modeling and simulation in the department of clinical pharmacology at Actelion Pharmaceuticals Ltd in Allschwil, Switzerland.

Graphics and visualization are a key element of his work as evidenced by a multitude of presentations and workshops. Recent publications include Interactive Visualization of Modeling Results for Effective Team Communication and Decision Making and Visualization Concepts for Modeling and Simulation (the former with Ronald Gieschke, the latter with Kevin Dykstra and Richard Pugh), both in the Journal of Clinical Pharmacology, 50(9), 2010.

Andreas Krause is co-author of The Basics of S-Plus (with Melvin Olson, Springer-Verlag, 1997-2005) and co-editor of Applied Statistics in the Pharmaceutical Industry (with Steve Millard, Springer-Verlag, 2001).

 Michael O’Connell

Michael O'Connell leads the Industry Analytics Group at TIBCO Software, developing analytic solutions across a number of industries including Life Sciences, Financial Services, Energy, Consumer Goods & Retail, and Telco, Media & Networks. He has been working on statistical software applications for the past 20 years, and has published more than 50 papers and several software packages on statistical methods. Michael has been particularly active in developing statistical graphics applications for review and reporting in clinical development, as has received several industry awards for his work in Life Sciences including recently being voted in the Top 100 Inspiring People in the Pharmaceutical Industry.  Michael did his Ph.D. work in Statistics at North Carolina State University and is an Adjunct ProfessorStatistics in the department.