Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

Scientific and Clinical Aspects of Anemia in Cancer
2. rev. and enlarged Auflage 2008
ISBN: 978-3-211-25223-9
Verlag: Springer

Buch, Englisch, 866 Seiten, Format (B × H): 170 mm x 244 mm, Gewicht: 1631 g

Anemia is a frequent complication of cancer and of its treatments. It produces many unwanted symptoms and significantly impairs metabolic and physiologic functions, as well as patients' activity, well-being and quality of life. Life expectancy can also be adversely affected. This book, now in its second edition, offers a comprehensive presentation of current knowledge on anemia in cancer and its treatment with Recombinant Human Erythropoietin (rhEPO). In expanded, updated and newly added chapters, including a broader spectrum of topics, outstanding international experts describe the scientific and clinical aspects of anemia in various fields of oncology and give diagnostic and therapeutic recommendations on when and how to use rhEPO. Future prospects in research and development are also discussed. The book, widely considered a standard work, will continue to serve as an essential source of information for radiotherapists, medical oncologists, hematologists, internists, pediatricians, surgeons, specialists in transfusion and laboratory medicine, and pharmacologists.

Zielgruppe

Research

Autoren/Hrsg.

Nowrousian, Mohammad Resa

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hämatologie, Transfusionsmedizin
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Nuklearmedizin, PET, Radiotherapie

Inhaltsverzeichnis

Physiology of erythropoiesis.- Biology of EPO and EPO-receptor.- The role of erythropoietin receptor expression on tumor cells.- Problems associated with erythropoietin receptor determination on tumor cells.- Definition, classification and characterization of anemia in cancer.- Pathophysiology of anemia in cancer.- Prevalence and incidence of anemia and risk factors for anemia in patients with cancer.- Significance of anemia in cancer chemotherapy.- Incidence and impact of anemia in radiation oncology.- Relationship between hemoglobin levels and tumor oxygenation.- Tumor hypoxia and therapeutic resistance.- Symptoms of anemia.- Impact of anemia and red blood cell transfusion on organ function.- Relationship of hemoglobin, fatigue, and quality of life in anemic cancer patients.- When to use red blood cell transfusions in cancer patients with solid tumours?.- Pharmacology, pharmacokinetics and safety of recombinant human erythropoietin preparations.- Epoetin treatment of anemia associated with multiple myeloma and non-Hodgkin’s lymphoma.- rhEPO in anemic patients with solid tumors and chemotherapy — efficacy and safety.- Early intervention with recombinant human erythropoietin for chemotherapy-induced anemia.- Recombinant human erythropoietin (rhEPO) therapy in myelodysplasia.- Prediction of response to rhEPO in the anemia of cancer.- rhEPO in hematopoietic stem cell transplantation.- Treatment of anemia with rhEPO in radiation oncology.- Recombinant human erythropoietin in pediatric oncology.- rhEPO in surgical oncology.- Erythropoiesis, iron metabolism and iron supplementation during erythropoietin therapy.- Are there risks for use of iron in cancer patients?.- Metabolic and physiologic effects of rhEPO in anemic cancer patients.- Effects of rhEPO on quality of lifein anemic cancer patients.- Thrombosis during therapy with erythropoiesis stimulating agents in cancer.- The effect of rhEPO on survival in anemic cancer patients.- From bench to bedside: Neuroprotective effects of erythropoietin.- rhEPO in patients with anemia and congestive heart failure.- Cost-effectiveness of treating cancer anaemia.