Jasper's Basic Mechanisms of the Epilepsies

Neuausgabe 2012
ISBN: 978-0-19-974654-5
Verlag: OXFORD UNIV PR

Buch, Englisch, Band 80, 1264 Seiten, Format (B × H): 178 mm x 259 mm, Gewicht: 2903 g

Reihe: Contemporary Neurology Series

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade
and a half with these goals in mind — assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past
four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease
mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This
book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical
importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Zielgruppe

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment. The book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies. This book is now formatted to be used as a course textbook. It may be also used as supplementary reading for graduate courses in neuroscience and neurology that focus on the pathophysiology of neurological disease. Most clinical epileptologists and epilepsy research investigators at will likely purchase a laboratory copy.

Autoren/Hrsg.

Noebels, Jeffrey

Avoli, Massimo

Rogawski, Michael

Olsen, Richard

Delgado-Escueta, Antonio

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

SECTION 1 INTRODUCTION

1. THE NEXT DECADE OF RESEARCH IN THE BASIC MECHANISMS OF THE EPILEPSIES
2. HERBERT H. JASPER AND THE BASIC MECHANISMS OF THE EPILEPSIES
Massimo Avoli
3. Why - and how - do we approach basic epilepsy research
Section II: Fundamentals of neuronal excitability relevant to seizures and epilepsy
4. Voltage-gated Na+ Channels: Structure, Function, and Pathophysiology
Massimo Mantegazza and William A. Catterall
5. Potassium channels (including KCNQ) and epilepsy
Edward C. Cooper
6. Voltage-gated calcium channels in epilepsy
Stuart M Cain and Terrance P Snutch
7. Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channelopathy in epilepsy
Nicholas P. Poolos
8. Phasic GABAA-mediated inhibition
Enrico Cherubini
9. Tonic GABAA receptor-mediated signaling in epilepsy
Matthew C Walker and Dimitri M Kullmann
10. Glutamatergic mechanisms related to epilepsy: ionotropic receptors
Raymond Dingledine
11. Glutamate rECEPTORS IN epilepsy: Group I mGluR-MEDIATED epileptogenesis
Riccardo Bianchi, Robert K. S. Wong, and Lisa R. Merlin
12. Plasticity of Glutamate Synaptic Mechanisms
J. Victor Nadler
13. Neuronal synchronization and thalamocortical rhythms in sleep, wake and epilepsy Igor Timofeev, Maxim Bazhenov, Josée Seigneur, Terrence Sejnowski
14. Limbic Network Synchronization and Temporal Lobe Epilepsy
John G R Jefferys, Premysl Jiruska, Marco de Curtis, Massimo Avoli
15. Imaging of Hippocampal Circuits in Epilepsy
Hajime Takano and Douglas A. Coulter
16. Normal and Pathologic High-Frequency Oscillations
Richard J. Staba
17. INTERICTAL EPILEPTIFORM DISCHARGES IN PARTIAL EPILEPSY: COMPLEX NEUROBIOLOGICAL MECHANISMS BASED ON EXPERIMENTAL AND CLINICAL EVIDENCE
Marco de Curtis, John G R Jefferys, and Massimo Avoli
18. GABA-A RECEPTOR FUNCTION IN TYPICAL ABSENCE SEIZURES
Vincenzo Crunelli, Nathalie Leresche, and David W. Cope
19. GABAB RECEPTOR AND ABSENCE EPILEPSY
Hua A. Han, Miguel A. Cortez, and O. Carter Snead III
20. Brainstem networks: Reticulo-cortical synchronization in Generalized Convulsive Seizures
Carl L. Faingold
21. ON THE BASIC MECHANISMS OF INFANTILE SPASMS
John W. Swann and Solomon L. Moshe
22. Fast oscillations and synchronization examined with in vitro models of epileptogenesis
Roger D. Traub, Miles A. Whittington, Mark O. Cunningham
23. Computer Modeling of Epilepsy
Marianne J. Case, Robert J. Morgan, Calvin J. Schneider, Ivan Soltesz
Section III - Mechanisms of seizures susceptibility and epileptogenesis
24. Traumatic brain injury and posttraumatic epilepsy
David A. Prince, Isabel Parada, Kevin Graber
25. HEAD TRAUMA AND EPILEPSY
Asla Pitkänen and Tamuna Bolkvadze
26. Fever, febrile seizures and epileptogenesis
Céline M. Dubé, Shawn McClelland, ManKin Choy, Amy L. Brewster, Yoav Noam, Tallie Z. Baram
27. Role of Blood-Brain Barrier Dysfunction in Epileptogenesis
Alon Friedman and Uwe Heinemann
28. Cell death and survival mechanisms after single and repeated brief seizures
David C. Henshall1 and Brian S. Meldrum
29. PROGRAMMED NECROSIS AFTER STATUS EPILEPTICUS
Jerome Niquet, Maria-Leonor Lopez-Meraz, Claude G. Wasterlain
30. HISTOPATHOLOGY OF HUMAN EPILEPSY
Nihal C. de Lanerolle, Tih-Shih Lee, and Dennis D. Spencer
31. The Time Course and Circuit Mechanisms of Acquired Epileptogenesis
F. Edward Dudeka and Kevin J. Staley
32. Mossy Fiber Sprouting in the Dentate Gyrus
Paul S. Buckmaster
33. Kainate and Temporal Lobe Epilepsies: 3 decades of progress
Yehezkel Ben-Ari
34. Abnormal dentate gyrus network circuitry in temporal lobe epilepsy
Robert S. Sloviter, Argyle V. Bumanglag, Robert Schwarcz, and Michael Frotscher
35. Alterations in synaptic function in epilepsy
Christophe Bernard
36. Seizure-induced formation of basal dendrites on granule cells of the rodent dentate gyrus
Charles E. Ribak, Lee A. Shapiro, Xiao-Xin Yan, Khashayar Dashtipour, J. Victor Nadler, Andre Obe

Über Autor(innen)

Rogawski, Michael
Michael A. Rogawski, MD, PhD Dr. Rogawski is professor and chair of the Department of Neurology at the University of California, Davis School of Medicine. He previously served as chief of the Epilepsy Research Section at the National Institute of Neurological Disorders and Stroke. His research is on the cellular mechanisms of action of antiepileptic drugs and new epilepsy treatment approaches.

Delgado-Escueta, Antonio
Antonio V. Delgado-Escueta, MD Dr. Delgado-Escueta is Professor in Residence in Neurology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA). He is also director of the Epilepsy Center of Excellence at the VA Greater Los Angeles Healthcare System in West Los Angeles. The focus of his research is isolating human epilepsy genes and defining their disease mechanisms.

Olsen, Richard
Richard W. Olsen, PhD Dr. Olsen is Distinguished Professor of Neuroscience, Pharmacology, and Anesthesiology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA), in the Department of Molecular & Medical Pharmacology. The focus of his research is the structure and function of GABA-A receptors in the brain including their involvement in epilepsy and alcoholism.

Noebels, Jeffrey
Jeffrey L. Noebels MD, PhD Dr. Noebels is Cullen Trust for Health Care Endowed Chair Professor of Neurology, Neuroscience, and Molecular and Human Genetics at Baylor College of Medicine. He is also Vice Chair for Research and Director of the Blue Bird Circle Developmental Neurogenetics Laboratory in the Department of Neurology. The focus of his research is on genetic and cellular mechanisms of neuronal synchronization disorders in the developing brain.

Avoli, Massimo
Massimo Avoli, MD Dr. Avoli is Professor in the Department of Neurology and Neurosurgery, and in the Department of Physiology at McGill University. He is also Professor of Human Physiology at Sapienza University of Rome. His research focuses on the cellular and pharmacological mechanisms underlying excitability and epileptiform synchronization, epileptogenesis, and mental retardation syndromes.

Jeffrey L. Noebels MD, PhD
Dr. Noebels is Cullen Trust for Health Care Endowed Chair Professor of Neurology, Neuroscience, and Molecular and Human Genetics at Baylor College of Medicine. He is also Vice Chair for Research and Director of the Blue Bird Circle Developmental Neurogenetics Laboratory in the Department of Neurology. The focus of his research is on genetic and cellular mechanisms of neuronal synchronization disorders in the developing brain.

Massimo Avoli, MD
Dr. Avoli is Professor in the Department of Neurology and Neurosurgery, and in the Department of Physiology at McGill University. He is also Professor of Human Physiology at Sapienza University of Rome. His research focuses on the cellular and pharmacological mechanisms underlying excitability and epileptiform synchronization, epileptogenesis, and mental retardation syndromes.

Michael A. Rogawski, MD, PhD
Dr. Rogawski is professor and chair of the Department of Neurology at the University of California, Davis School of Medicine. He previously served as chief of the Epilepsy Research Section at the National Institute of Neurological Disorders and Stroke. His research is on the cellular mechanisms of action of antiepileptic drugs and new epilepsy treatment approaches.

Dr. Olsen is Distinguished Professor of Neuroscience, Pharmacology, and Anesthesiology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA), in the Department of Molecular & Medical Pharmacology. The focus of his research is the structure and function of GABA-A receptors in the brain including their involvement in epilepsy and alcoholism.

Antonio V. Delgado-Escueta, MD
Dr. Delgado-Escueta is Professor in Residence in Neurology at the David Geffen School of Medicine at the University of California Los Angeles (UCLA). He is also director of the Epilepsy Center of Excellence at the VA Greater Los Angeles Healthcare System in West Los Angeles. The focus of his research is isolating human epilepsy genes and defining their disease mechanisms.