Ankylosing Spondylitis - Axial Spondyloarthritis

Cellular, Molecular and Environmental Factors
1. Auflage 2022
ISBN: 978-981-16-4732-1
Verlag: Springer Nature Singapore

Buch, Englisch, 188 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 507 g

Ankylosing Spondylitis is a chronic autoimmune disease that affects about 1-3% of the world population. This debilitating disease affecting primarily young males exerts considerable socio-economic consequences. The exact pathogenesis of AS has not yet been fully understood; therefore, novel, detailed information sources are required.

This book offers cutting-edge knowledge about the molecular basic and immunological mechanisms involved in the pathogenesis of Ankylosing Spondylitis. It is one of the scarce scientific resources discussing the environmental factors triggering the disease, along with the clinical manifestations, diagnostic methods, and treatments. This book covers the most recent and reliable researches and developments about spondyloarthropathies in order to provide elaborated, integrated guidance on the molecular mechanisms of Spondyloarthropathies. It will prove helpful for rheumatologists, immunologists, biologists, geneticists, and medical science students who wish to learn more about SpAs.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Nicknam, Mohammad Hossein

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Rheumatologie, Muskelerkrankungen
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Chirurgie Orthopädie- und Unfallchirurgie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Orthopädie, konservativ

Inhaltsverzeichnis

Part 1 Introduction.- 1 An overview to Ankylosing spondylitis and Spondyloarthropathies.- Part 2 Cells and cytokines.- 2 Innate Immune-Related Cells and Cytokines in Spondyloarthropathies.- 3 Adaptive Immune-Related Cells and Cytokines in Spondyloarthropathies.- Part 3.- 4 Association of HLA and HLA Related Genes with Ankylosing Spondylitis.- 5 Association of non-HLA genes with ankylosing spondylitis.- Part 4.- Environmental factors.- 6 Spondyloarthropathies and Gut microbiota.- 7 Spondyloarthropathies and Food Intake.- 8 Spondyloarthropathies and Environmental Stresses.

Über Autor(innen)

Dr. Nicknam obtained his medical and Ph.D. degree in Clinical Immunology from Tehran University of Medical Sciences. He also has a fellowship in Clinical Immunology in Pittsburgh University, Pennsylvania. Since 2010, Prof. Nicknam has worked as the head of the Department of Immunology and Biology, School of Medicine, Tehran University of Medical Sciences. He is responsible for a great deal of international affairs of Tehran University of Medical Sciences and the co-founder and Head of the Molecular Immunology Research Center.

Dr. Nicknam is also an expert on spondyloarthropathies (SpA); in particular, genetics and molecular factors that influence the development of SpA. He is a pioneer in understanding the role of immunologically related gene polymorphisms and describing relevant associations of HLA-B27 subtypes with AS. He is a member of several scientific organizations.