Bioprocess Technology

Kinetics and Reactors
Softcover Nachdruck of the original 1. Auflage 1988
ISBN: 978-1-4613-8750-3
Verlag: Springer

Buch, Englisch, 451 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 727 g

This book is based on a 1981 German language edition published by Springer­ Verlag, Vienna, under the title Bioprozesstechnik. Philip Manor has done the translation, for which I am deeply grateful. This book differs from the German edition in many ways besides language. It is substantially enlargened and updated, and examples of computer simula­ tions have been added together with other appendices to make the work both more comprehensive and more practical. This book is the result of over 15 years of experience in teaching and research. It stems from lectures that I began in 1970 at the Technical University of Graz, Austria, and continued at the University of Western Ontario in London, Canada, 1980; at the Free University of Brussels, 1981; at Chalmers Technical University in G6teborg, Sweden; at the Academy of Sciences in lena, East Germany; at the "Haus der Technik" in Essen, West Germany, 1982; at the Academy of Science in Sofia, Bulgaria; and at the Technical University of Delft, Netherlands, 1986. The main goals of this book are, first, to bridge the gap that always exists between basic principles and applied engineering practice, second, to enhance the integration between biological and physical phenomena, and, third, to contribute to the internal development of the field of biotechnology by describing the process-oriented field of bioprocess technology.

Zielgruppe

Research

Autoren/Hrsg.

Moser, Anton

Weitere Mitwirkende

Manor, Philip

Inhaltsverzeichnis

1 Introduction.- 1.1 Biotechnology: A Definition and Overview.- 1.2 Bioprocess Technology.- 2 The Principles of Bioprocess Technology.- 2.1 Empirical Pragmatic Process Development.- 2.2 Basics of Quantification Methods for Bioprocesses.- 2.3 Systematic, Empirical Process Development with Mathematical Models.- 2.4 Mathematical Modeling in Bioprocessing.- 3 Bioreactors.- 3.1 Overview: Industrial Reactors.- 3.2 Systematics of Bioreactors.- 3.3 Quantification Methods.- 3.4 Operational Modes and Bioreactor Concepts.- 3.5 Bioreactor Models.- 3.6 “Perfect Bioreactors” in Bench and Pilot Scale for Process Kinetic Analysis.- 4 Process Kinetic Analysis.- 4.1 Kinetic Analysis in Different Types of Reactors.- 4.2 Regime Analysis—General Concept and Guidelines.- 4.3 Test of Pseudohomogeneity.- 4.4 Parameter Estimation of Kinetic Models with Bioreactors.- 4.5 Modeling Heterogeneous Processes.- 5 Bioprocess Kinetics.- 5.1 Temperature Dependence, k(T), Water Activity, aw, and Enthalpy/Entrophy Compensation.- 5.2 Microkinetic Equations Derived from the Kinetics of Chemical and Enzymatic Reactions.- 5.3 Basic Unstructured Kinetic Models of Growth and Substrate Utilization (Homogeneous Rate Equations).- 5.4 Kinetic Models for Microbial Product Formation.- 5.5 Multisubstrate Kinetics.- 5.6 Mixed Population Kinetics.- 5.7 Dynamic Models for Transient Operation Techniques (Nonstationary Kinetics).- 5.8 Kinetic Models of Heterogeneous Bioprocesses.- 5.9 Pseudokinetics.- 5.10 Kinetics of Sterilization.- 6 Bioreactor Performance: Process Design Methods.- 6.1 The Ideal Single-Stage, Constant-Volume Continuous Stirred Tank Reactor, CSTR (Pseudohomogeneous L-Phase Reactor Model).- 6.2 Variable Volume CSTR Operation (Fed-Batch and Transient Reactor Operation).- 6.3 Multistage Single and Multistream Continuous Reactor Operation.- 6.4 Continuous Plug Flow Reactors (CPFR).- 6.5 Recycle Reactor Operation.- 6.6 Gas/Liquid (Two-Phase) Reactor Models in Bioprocessing.- 6.7 Biofilm Reactor Operation.-6.8 Dialysis and Synchronous Culture Operation.- 6.9 Integrating Strategy as General Scale-Up Concept in Bioprocessing.- 6.10 Final Note.- Appendix I Fundamentals of Stoichiometry of Complex Reaction Systems.- Appendix II Computer Simulations.- Appendix III Microkinetics: Derivation of Kinetic Rate Equations from Mechanisms.