Miller / Tanner Essentials of Chemical Biology

Structure and Dynamics of Biological Macromolecules
1. Auflage 2013
ISBN: 978-1-118-68783-3
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 592 Seiten, E-Book

"This excellent work fills the need for an upper-levelgraduate course resource that examines the latest biochemical,biophysical, and molecular biological methods for analyzing thestructures and physical properties of biomolecules... Thisreviewer showed [the book] to several of his senior graduatestudents, and they unanimously gave the book rave reviews.Summing Up: Highly recommended..." CHOICE
Chemical biology is a rapidly developing branch of chemistry,which sets out to understand the way biology works at the molecularlevel. Fundamental to chemical biology is a detailed understandingof the syntheses, structures and behaviours of biologicalmacromolecules and macromolecular lipid assemblies that togetherrepresent the primary constituents of all cells and all organisms.The subject area of chemical biology bridges many differentdisciplines and is fast becoming an integral part of academic andcommercial research.
This textbook is designed specifically as a key teachingresource for chemical biology that is intended to build onfoundations lain down by introductory physical and organicchemistry courses. This book is an invaluable text for advancedundergraduates taking biological, bioorganic, organic andstructural chemistry courses. It is also of interest to biochemistsand molecular biologists, as well as professionals within themedical and pharmaceutical industry.
Key Features:
* A comprehensive introduction to this dynamic area of chemistry,which will equip chemists for the task of understanding andstudying the underlying principles behind the functioning ofbiological macro molecules, macromolecular lipid assemblies andcells.
* Covers many basic concepts and ideas associated with the studyof the interface between chemistry and biology.
* Includes pedagogical features such as: key examples, glossaryof equations, further reading and links to websites.
* Clearly written and richly illustrated in fullcolour.

Autoren/Hrsg.

Miller, Andrew

Miller, Andrew D.

Tanner, Julian

Tanner, Julian A.

Inhaltsverzeichnis

Preface.
Glossary of physical terms.
1. The structures of biological macromolecules and lipidassemblies.
1.1. General introduction.
1.2. Protein structure.
1.3. Carbohydrate structure.
1.4. Nucleic acid structure.
1.5. Macromolecular lipid assemblies.
1.6. Structural forces in biological macromolecules.
2. Chemical and biological synthesis.
2.1. Introduction to synthesis in chemical biology.
2.2. Chemical synthesis of peptides and proteins.
2.3. Chemical synthesis of nucleic acids.
2.4. Chemical synthesis of oligosaccharides.
2.5. Chemical synthesis of lipids.
2.6. Biological synthesis of biological macromolecules.
2.7. Directed biological synthesis of proteins.
2.8. Biological syntheses of nucleic acids, oligosaccharides andlipids.
3. Molecular biology as a toolset for chemicalbiology.
3.1. Key concepts in molecular biology.
3.2. Tools and techniques in molecular biology.
3.3. Cloning and identification of genes in DNA.
3.4. Integrating cloning and expression.
3.5. Site-directed mutagenesis
4. Electronic and vibrational spectroscopy.
4.1. Electronic and vibrational spectroscopy in chemicalbiology.
4.2. UV-visible spectroscopy.
4.3. Circular dichroism spectroscopy.
4.4. Vibrational spectroscopy.
4.5. Fluorescence spectroscopy.
4.6. Probing metal centres by absorption spectroscopy.
5. Magnetic resonance.
5.1. Magnetic resonance in chemical biology.
5.2. Key principles of NMR.
5.3. Two-dimensional NMR.
5.4. Multi-dimensional NMR.
5.5. Biological macromolecule structural information.
5.6. EPR spectroscopy; key principles.
6. Diffraction and microscopy.
6.1. Diffraction and microscopy in chemical biology.
6.2. Key principles of X-ray diffraction.
6.3. Structural information from X-ray diffraction.
6.4. Neutron diffraction.
6.5. Key principles of electron microscopy.
6.6. Key principles of scanning probe microscopy.
7. Molecular recognition and binding.
7.1. Molecular recognition and binding in chemical biology.
7.2. Theoretical models of binding.
7.3. Analysing molecular recognition and binding.
7.4. Biological molecular recognition studies.
8. Kinetics and catalysis.
8.1. Catalysis in chemical biology.
8.2. Steady state kinetic schemes.
8.3. Pre-steady-state kinetics.
8.4. Theories of biocatalysis.
8.5. Electron transfer.
9. Mass spectrometry and proteomics.
9.1. Mass spectrometry in chemical biology.
9.2. Key principles in mass spectrometry.
9.3. Structural analysis of biological macromolecules and lipidsby mass spectrometry.
9.4. The challenge of proteomics.
9.5. Genomics - assigning function to genes and proteins.
10. Molecular selection and evolution.
10.1. Chemical biology and the origins of life.
10.2. Molecular breeding; natural selection acting onself-organisation.
10.3. Directed evolution of protein function.
10.4. Directed evolution of nucleic acids.
10.5. Catalytic antibodies.
References.
Index.