Mikami / Lautens New Frontiers in Asymmetric Catalysis

1. Auflage 2007
ISBN: 978-0-470-09799-1
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 448 Seiten, E-Book

A compilation of recent advances and applications in asymmetriccatalysis
The field of asymmetric catalysis has grown rapidly and plays a keyrole in drug discovery and pharmaceuticals. New Frontiers inAsymmetric Catalysis gives readers a fundamental understanding ofthe concepts and applications of asymmetric catalysis reactions anddiscusses the latest developments and findings. With contributionsfrom preeminent scientists in their respective fields, itcovers:
* "Rational" ligand design, which is critically dependent on thereaction type (reduction, oxidation, and C-C bond formation)
* Recent findings on activation of C-H bonds, C-C bonds, and smallmolecules (C=O, HCN, RN=C, and CO2) and the latest developments onC-C bond reorganization, such as metathesis
* Advances in "chirally economical" non-linear phenomena, racemiccatalysis, and autocatalysis
* Some of the recent discoveries that have led to a renaissance inthe field of organocatalysis, including the development of chiralBrönstead acids and Lewis acidic metals bearing the conjugatebase of the Brönstead acids as the ligands and the chiralbi-functional acid/base catalysts
The book ends with a thought-provoking perspective on the future ofasymmetric catalysis that addresses both the challenges and theunlimited potential in this burgeoning field. This is anauthoritative, up-to-date reference for organic chemists inacademia, government, and industries, including pharmaceuticals,biotech, fine chemicals, polymers, and agriculture. It is also anexcellent textbook for graduate students studying advanced organicchemistry or chemical synthesis.

Autoren/Hrsg.

Mikami, Koichi

Lautens, Mark

Inhaltsverzeichnis

Introductory Preface (K. Mikami and M. Lautens).
Chapter 1. Ligand Design for Catalytic Asymmetric Reduction (T. Ohkuma, M. Kitamura, and R. Noyori).
Chapter 2. Ligand Design for Oxidation (T. Yamada)
Chapter 3. Ligand Design for C-C Bond Formation (R. Shintani and T. Hayashi).
Chapter 4. Activation of small molecules (C=O, HCN, RN=C, and CO2) (K. Nozaki).
Chapter 5. Asymmetric Synthesis Based on the Catalytic Activation of C-H and C-C Bonds (C.-J. Li).
Chapter 6. Recent Progress in the Metathesis Reaction M. Mori).
Chapter 7. Activation and De-activation (K. Mikami and K. Aikawa).
Chapter 8. Auto-Catalysis (K. Soai).
Chapter 9. Recent Advances in Catalytic Asymmetric Desymmetrization Reactions (T. Rovis).
Chapter 10. History & Perspective of Chiral Organic Catalysts (G.Lelais and D.W.C.Macmillan).
Chapter 11. Chiral Acid Catalysts (K. Ishihara and H. Yamamoto).
Chapter 12. Recent Advances in Chiral Base Catalysts (M. Shibasaki and Motomu Kanai).
Future perspective (K. Mikami and M. Lautens).

Über Autor(innen)

Koichi Mikami is Professor in the Department of AppliedChemistry at the Tokyo Institute of Technology.
Mark Lautens is AstraZeneca Professor of OrganicSynthesis and Merck Frosst/NSERC Industrial Research Chair in theDavenport Laboratories at the University of Toronto.