Merbach / Helm / Tóth The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

2. Auflage 2013
ISBN: 978-1-118-50366-9
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 512 Seiten, E-Book

Magnetic Resonance Imaging (MRI) is one of the most importanttools in clinical diagnostics and biomedical research. The numberof MRI scanners operating around the world is estimated to beapproximately 20,000, and the development of contrast agents,currently used in about a third of the 50 million clinical MRIexaminations performed every year, has largely contributed to thissignificant achievement.
This completely revised and extended secondedition:
* Includes new chapters on targeted, responsive, PARACEST andnanoparticle MRI contrast agents.
* Covers the basic chemistries, MR physics and the most importanttechniques used by chemists in the characterization of MRI agentsfrom every angle from synthesis to safety considerations.
* Is written for all of those involved in the development andapplication of contrast agents in MRI.
* Presented in colour, it provides readers with truerepresentation and easy interpretation of the images.
A word from the Authors:
Twelve years after the first edition published, we areconvinced that the chemistry of MRI agents has a bright future. Byassembling all important information on the design principles andfunctioning of magnetic resonance imaging probes, this book intendsto be a useful tool for both experts and newcomers in the field. Wehope that it helps inspire further work in order to create moreefficient and specific imaging probes that will allow materializingthe dream of seeing even deeper and better inside the livingorganisms.
Reviews of the First Edition:
"...attempts, for the first time, to review the whole spectrumof involved chemical disciplines in thistechnique..."--Journal of the American Chemical Society"...well balanced in its scope and attention to detail...a valuableaddition to the library of MR scientists..."--NMR inBiomedicine

Autoren/Hrsg.

Merbach, Andre S.

Helm, Lothar

Tóth, Éva

Inhaltsverzeichnis

List of Contributors
Preface
1 GENERAL PRINCIPLES OF MRI
2 RELAXIVITY OF GADOLINIUM(III) COMPLEXES: THEORY AND MECHANISM
3 SYNTHESIS AND CHARACTERIZATION OF LIGANDS AND THEIR GADOLINIUM(III) COMPLEXES
4 STABILITY AND TOXICITY OF CONTRAST AGENTS
5 STRUCTURE, DYNAMICS AND COMPUTATIONAL STUDIES OF LANTHANIDE BASED CONTRAST AGENTS
6 ELECTRONIC SPIN RELAXATION AND OUTER-SPHERE DYNAMICS OF GADOLINIUM-BASED CONTRAST AGENTS
7 TARGETED MRI CONTRAST AGENTS
8 RESPONSIVE PROBES
9 PARAMAGNETIC CEST MRI CONTRAST AGENTS
10 Superparamagnetic Iron Oxide Nanoparticles for MRI
11 GD-CONTAINING NANOPARTICLES AS MRI CONTRAST AGENTS
Subject Index