McGuffin / Murray The New Genetics of Mental Illness

1. Auflage 2013
ISBN: 978-1-4831-6427-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 316 Seiten, Web PDF

The New Genetics of Mental Illness is a collection of papers that discusses the advancement of molecular biology in the context of psychiatry. The book presents papers that are organized thematically. The text first discusses the basics of biology and quantitative models, and then proceeds to covering linkage analysis. Next, the book deals with various mental disorders, including schizophrenia, eating disorders, and developmental disorders. The remaining materials turn their attention to dementia and Huntington's disease. The book will be of great use to researchers and practitioners of behavioral sciences, such as psychology and psychiatry.

Autoren/Hrsg.

McGuffin, Peter

Murray, Robin

Inhaltsverzeichnis

1;Front Cover;1
2;The New Genetics of Mental Illness
;4
3;Copyright Page;5
4;Table of Contents;6
5;Contributors;8
6;Preface;11
7;Chapter 1. The cell, molecular biology and the new genetics
;14
7.1;THE STRUCTURE AND FUNCTION OF CHROMOSOMES;14
7.2;GENETICS AND THE MOLECULAR BASIS OF HEREDITY;19
7.3;THE NEW GENETICS;24
7.4;THE APPLICATION OF MOLECULAR GENETICS TO THE STUDY OF DISEASE
;28
7.5;THE STUDY OF GENE EXPRESSION;35
7.6;CONCLUSIONS;37
7.7;REFERENCES;38
8;Chapter 2. Genetic models of madness;40
8.1;SIMPLE GENETIC MODELS AND IRREGULAR TRAITS;42
8.2;MULTIFACTORIAL MODELS;45
8.3;ITERATIVE MODEL FITTING;49
8.4;SEGREGATION ANALYSIS;51
8.5;THE BENEFITS AND LIMITATIONS OF QUANTITATIVE MODELS
;53
8.6;REFERENCES;54
9;Chapter 3. The uses and abuses of linkage analysis in neuropsychiatric disorder
;57
9.1;INTRODUCTION;57
9.2;LINKAGE STUDIES;58
9.3;ILLUSTRATION AND INTERPRETATION;63
9.4;CONCLUSION;66
9.5;REFERENCES;67
10;Cgapter 4. The formal problems of linkage;71
10.1;THE APPLICATION OF NEW METHODS;72
10.2;THE PROBLEMS OF STUDYING THE PSYCHOSES;73
10.3;GENES RELATED TO BRAIN FUNCTION;73
10.4;THE NATURE OF LINKAGE;74
10.5;THE BASIS OF LINKAGE ANALYSIS;75
10.6;PROCEDURES FOR INCREASING THE YIELD OF LINKAGE DATA
;79
10.7;REFERENCES;82
11;Chapter 5. Schizophrenia: How far can we go in defining the phenotype?
;84
11.1;WHICH CRITERIA ARE THE 'MOST VALID' FOR GENETIC RESEARCH?
;85
11.2;THE LIMITATIONS OF OPERATIONAL CRITERIA;86
11.3;A POLYDIAGNOSTIC APPROACH TO THE CLASSIFICATION OF PSYCHOTIC ILLNESS
;88
11.4;CONCLUSIONS;95
11.5;REFERENCES;95
12;Chapter 6. Schizophrenia: Classical approaches with new twists and provocative results
;98
12.1;HISTORICAL DEMOGRAPHY AND CONTEMPORARY EPIDEMIOLOGY
;98
12.2;FAMILIAR FAMILIAL RISKS AS CLUES TO MODE OF TRANSMISSION
;102
12.3;UNEXPRESSED GENOTYPES, PATHOPLASTIC PHENOTYPES, AND COMPLEXITY
;105
12.4;CONCLUSIONS;108
12.5;REFERENCES;108
13;Chapter 7. Genetic linkage studies of schizophrenia
;111
13.1;INTRODUCTION;111
13.2;GENETICS AND SCHIZOPHRENIA;111
13.3;CONCLUSIONS;119
13.4;ACKNOWLEDGEMENTS;120
13.5;REFERENCES;120
14;Chapter 8. Aberrant neurodevelopment as the expression of the schizophrenia genotype
;125
14.1;NEURO-IMAGING STUDIES;126
14.2;EARLY DEVELOPMENTAL FACTORS;127
14.3;NEURODEVELOPMENT AND NEUROPATHOLOGY;128
14.4;GENETIC SPECIFICATION OF NEURODEVELOPMENT;133
14.5;CONCLUSION;135
14.6;ACKNOWLEDGEMENTS;136
14.7;REFERENCES;136
15;Cha[pter 9. The familial aggregation of affective disorders: relation to symptom severity and social provocation;143
15.1;CASE DEFINITION AS A PREREQUISITE OF GENETIC EPIDEMIOLOGY
;143
15.2;EPIDEMIOLOGICAL PITFALLS IN GENETIC RESEARCH;144
15.3;STRATEGIC APPROACHES TO THE GENETICS OF AFFECTIVE DISORDERS
;145
15.4;THE CAMBERWELL DEPRESSION STUDY;149
15.5;REFERENCES;156
16;Chapter 10. Life events and depressive symptoms: a twin study perspective
;159
16.1;INTRODUCTION;159
16.2;METHODS;160
16.3;RESULTS;162
16.4;DISCUSSION;172
16.5;ACKNOWLEDGEMENTS;176
16.6;REFERENCES;176
17;Chapter 11. Genetic markers and affective disorder
;178
17.1;THE EVIDENCE FOR GENETIC INFLUENCES;179
17.2;MODE OF INHERITANCE;182
17.3;GENETIC MARKERS;184
17.4;CONCLUSIONS AND FUTURE PROSPECTS;190
17.5;REFERENCES;191
18;Chapter 12. The genetics of vulnerability to alcoholism
;195
18.1;CLASSICAL GENETIC STUDIES;195
18.2;HIGH RISK STUDIES;201
18.3;ALCOHOL CHALLENGE STUDIES IN TWINS;202
18.4;GENETIC MARKERS;203
18.5;ALCOHOL-METABOLIZING ENZYMES;204
18.6;MAPPING ALCOHOL-RELATED BEHAVIOURAL TRAITS IN MICE
;205
18.7;CONCLUSIONS;206
18.8;REFERENCES;207
19;Chapter 13. Genes and the aetiology of eating disorders
;211
19.1;RECENT EVIDENCE FOR FAMILIAL FACTORS IN THE AETIOLOGY OF ANOREXIA NERVOSA
;212
19.2;ACKNOWLEDGEMENTS;221
19.3;REFERENCES;221
20;Chapter 14. Growing together and growing apart: the non-genetic forces on children in the same family
;225
20.1;DOES SHARED ENVIRONMENT MATTER?;227
20.2;THE ROLE OF CHANCE IN BRAIN DEVELOPMENT;228
20.3;MEASUREMENT ERROR;232
20.4;POLARIZING AND EQUALIZING EFFECTS;233
20.5;REFERENCES;236
21;Chapter 15. Autism as a genetic disorder;238
21.1;TWIN STUDIES;239
21.2;FAMILY STUDIES;242
21.3;ASSOCIATED SINGLE-GENE CONDITIONS AND CHROMOSOME ANOMALIES
;248
21.4;DILEMMAS AND PROSPECTS;250
21.5;REFERENCES;253
22;Chapter 16. Learning disability and psychiatric/behavioural disorders: a genetic perspective
;258
22.1;INTRODUCTION;258
22.2;DOWN'S SYNDROME AND ALZHEIMER'S DISEASE;260
22.3;THE PRADER-WILLI SYNDROME, OBESITY ANDOVER-EATING;263
22.4;FUTURE DEVELOPMENTS;265
22.5;CONCLUSIONS;267
22.6;ACKNOWLEDGEMENTS;268
22.7;REFERENCES;268
23;Chapter 17. The genetics of the commonforms of dementia;272
23.1;INTRODUCTION;272
23.2;TWIN AND FAMILY STUDIES IN ALZHEIMER'S DISEASE;273
23.3;AGEING IN ALZHEIMER'S DISEASE;276
23.4;GENETIC LINKAGE STUDIES IN ALZHEIMER'S DISEASE;278
23.5;CONCLUSIONS;279
23.6;REFERENCES;283
24;Chapter 18. The molecular basis ofAlzheimer's-type dementia;287
24.1;WHAT IS THE AETIOLOGY OF LATE-ONSET, FAMILIALALZHEIMER'S DISEASE?;289
24.2;WHAT IS THE AETIOLOGY OF ALZHEIMER'S DISEASE INTHE VOLGA GERMAN POPULATION?;289
24.3;INTERPRETATION OF RECOMBINANTS: GOING FROMLINKAGE TO GENE;290
24.4;IS ALZHEIMER'S DISEASE HETEROGENEOUS AT THEMOLECULAR LEVEL? A UNIFYING HYPOTHESIS;291
24.5;REFERENCES;292
25;Chapter 19. Prediction and prevention inHuntington s disease;294
25.1;INTRODUCTION;294
25.2;PREVALENCE;294
25.3;EARLY ATTEMPTS AT PREDICTION;296
25.4;GENE MAPPING;298
25.5;PREDICTIVE TESTING;299
25.6;PROGRESS TOWARDS IDENTIFICATION OF THE HUNTINGTON'S DISEASE GENE
;304
25.7;ACKNOWLEDGEMENTS;305
25.8;REFERENCES;306
26;Index;312