E-Book, Englisch, 236 Seiten, Web PDF
Mattson Membrane Lipid Signaling in Aging and Age-Related Disease
1. Auflage 2003
ISBN: 978-0-08-052250-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 236 Seiten, Web PDF
ISBN: 978-0-08-052250-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.
This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.
Autoren/Hrsg.
Weitere Infos & Material
1;Cover;1
2;TABLE OF CONTENTS;6
3;Preface;8
4;Chapter 1. Overview: Spatial Control of Signal Transduction by Caveolae and Lipid Rafts ;12
5;Chapter 2. Overview: Membrane Lipid Peroxidation;22
6;Chapter 3. Regulation of Invertebrate Longevity by Inositol Phosphate Signaling;38
7;Chapter 4. Ceramide-Driven Stress Signals in Cancer and Aging;58
8;Chapter 5. Sphingolipid Metabolism and Signaling in Atherosclerosis;82
9;Chapter 6. Sphingomyelin and Ceramide in Brain Aging, Neuronal Plasticity and Neurodegenerative Disorders ;108
10;Chapter 7. The Eicosanoid Pathway and Brain Aging;128
11;Chapter 8. Cellular Cholesterol, Membrane Signaling, and Disease;148
12;Chapter 9. Cholesterol, ß-amyloid, and Alzheimer’s Disease;174
13;Chapter 10. Phospholipase A2 in the Pathogenesis of Cardiovascular Disease;188
14;Chapter 11. Retinal Docosahexaenoic Acid, Age-Related Diseases, and Glaucoma;216
15;List of Contributors;234