Targeted Metallo-Drugs

Design, Development, and Modes of Action
1. Auflage 2024
ISBN: 978-1-032-22353-7
Verlag: Taylor & Francis Ltd

Buch, Englisch, 390 Seiten, Format (B × H): 228 mm x 152 mm, Gewicht: 634 g

Reihe: Metal Ions in Life Sciences Series

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.

- It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy

- It highlights recent metallo-drug developments targeting COVID-19

- It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs

Zielgruppe

Postgraduate, Professional, Undergraduate Advanced, and Undergraduate Core

Autoren/Hrsg.

Marmion, Celine J.

Farkas, Etelka

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Anorganische Chemie
• Naturwissenschaften Chemie Chemie Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli by Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol. Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy by Dmytro Havrylyuk, Austin Hachey, and Edith Glazer. Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes by Andrea Erxleben. Chapter 4 Transition Metal-Based Antiviral Agents against SARS-CoV-2 and Other Pathogenic Viruses by Maria Gil-Moles and Ingo Ott. Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs by Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi, and Luigi Messori. Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug-Resistant Bacteria by Andris Evans and Kevin Kavanagh. Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases by Dinorah Gambino and Lucía Otero. Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment by Sigridur G. Suman. Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells by Johannes Karges and Nils Metzler-Nolte. Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine by Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun. Chapter 11 Metal-Based Nanoclusters for Biomedical Applications by Edit Csapó. Chapter 12 Radiometals in Molecular Imaging and Therapy by Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikolajczak.

Über Autor(innen)

Etelka Farkas was appointed Full Professor of Chemistry at the University of Debrecen in 1999. After receiving her scientific degree (D.Sc.) from the Hungarian Academy of Sciences (HAS) in 1998, she has worked as elected member in some HAS Committees, e.g., the Committee on Physical Chemistry and Inorganic Chemistry (2011-), the Doctoral Council of Chemical Sciences (2018-2021), and she chaired the Working Commitee of Coordination Chemistry (2011-2017). From 2006-2019 she was also Chair of the International Relations of the Hungarian Chemical Society. She received many awards; to mention just three of them: (2005) Gold Cross of Merit of the Hungarian Republic; (2012) Albert Szent-Györgyi Award; (2019) Faculty of Science and Technology Award of the University of Debrecen. Professor Farkas was Editor of the RSC Specialist Periodical Reports (Vols. 37, 38, and 39) on Amino Acids, Peptides, and Proteins for the years 2012, 2013, and 2015. Furthermore, she was Guest Editor of the Special Issue 472 (2018) of Inorganica Chimica Acta and of the issue 206 (2020) of the Journal of Inorganic Biochemistry. Professor Farkas is very familiar with the MILS series having co-authored chapters in previous volumes.

Celine J. Marmion was appointed Full Professor of Bioinorganic Chemistry at the Royal College of Surgeons in Ireland (now RCSI University of Medicine and Health Sciences) in 2018. She is currently President of the Institute of Chemistry of Ireland, the national body representing all chemists in Ireland, the third female only to be elected as President since its establishment in 1922. She also co-founded the Irish Biological Inorganic Chemistry Society (IBICS) in 2017 and served as its President from 2018-2019. She has received several awards, among these is the prestigious RCSI Dean's Award in 2016 for 'Endeavour, Innovation, Collaboration and Service' to RCSI, an award presented to only one academic across the University each year. More

recently, she was the recipient of a national 'Teaching Hero' award in 2021 and also in 2016 (as nominated by students) as well as the recipient of several RCSI President's Teaching Awards. Her current research focuses on the rational design and development of multi-targeted metallodrug candidates for therapeutic exploitation. Professor Marmion is well familiar with the MILS series having published comprehensive reviews of two volumes.