Molecular Basis and Thermodynamics of Bioelectrogenesis

1990
ISBN: 978-0-7923-0975-8
Verlag: Springer Netherlands

Buch, Englisch, Band 5, 182 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1000 g

Reihe: Topics in Molecular Organization and Engineering

Despite the fact that many years have elapsed since the first microcalorimetric measurements of an action potential were made, there is still among the research workers involved in the study of bioelectrogenesis a complete overlooking of the most fundamental principle governing any biological phenomenon at the molecular scale of dimension. This is surprising, the more so that the techniques of molecular biology are applied to characterize the proteins forming the ionic conducting sites in living membranes. For reasons that are still obscure to us the molecular aspects of bioelectrogenesis are completely out of the scope of the dynamic aspects of biochemistry. Even if it is sometimes recognized that an action potential is a free energy-consuming, entropy-producing process, the next question that should reasonably arise is never taken into consideration. There is indeed a complete evasion of the problem of biochemical energy coupling thus reducing the bioelectrogenesis to only physical interactions of membrane proteins with the electric field: the inbuilt postulate is that no molecular transformations, in the chemical sense, could be involved.

Zielgruppe

Research

Autoren/Hrsg.

Margineanu, D. G.

Schoffeniels, E.

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Naturwissenschaften Chemie Physikalische Chemie Quantenchemie, Theoretische Chemie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie

Inhaltsverzeichnis

I The Description in Physico-Chemical Terms of Nervous System Properties.- I.1. Living systems as dissipative structures with local quasi equilibrium.- I.2. Information flows in living systems.- I.3. Evolution of the ideas about bioelectrogenesis. A brief account.- References.- II Cell Membranes and Bioelectrogenesis.- II.1. The ubiquitous cellular component.- II.2. Membrane molecular components and their dynamics.- II.3. Silent and excitable membranes.- References.- III Phenomenological Aspects of Bioelectricity.- III.1. Resting potential of the cells.- III.2. The passive propagation of potential changes. Axons as electric cables.- III.3. Regenerative propagation of action potentials in excitable membranes.- III.4. Intercellular transmission of excitation.- III.5. An overview of bioelectric phenomena.- References.- IV Molecular Approaches of Bioelectricity.- A. Intermediary metabolism in brain.- B. Control of glycolysis.- C. Non oxidative consumption of glucose during neural activity.- D. The pentose shunt.- E. The amino acids pool.- F. Concluding remarks.- References.- V Puzzle of Nerve Impulse Thermodynamics.- V.1. Oxygen consumption and heat production inactive nerve.- V.2. Energy dissipation by Na+/K+ pumps in nerves.- V.3. Energy changes during the action potential.- V.4. Thermodynamic inconsistency of the kinetics of n, m and h parameters.- References.- VI Thiamine Triphosphate as the Specific Operative Substance in Spike-Generation.- Conclusion.- References.- VII. Merging Electrophysiology and Molecular Approaches.- VII.1. Single-channel recording.- VII.2. The structure of channel proteins.- VII.3. From molecular mechanisms to complex brain functions.- VII.4. Levels of unitary events.- References.- Index of Names.- Index of Subjects.