Pharmacogenetics

1. Auflage 2012
ISBN: 978-0-470-43354-6
Verlag: Wiley

Buch, Englisch, 510 Seiten, Format (B × H): 161 mm x 240 mm, Gewicht: 918 g

The one-stop reference to pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practices

Pharmacogenetics and Individualized Therapy offers thorough coverage of the study of the genetic determinants of drug response at the single gene level-and its impact on pharmaceuticals, therapeutics, and clinical practice. Providing an overview of the molecular basis of pharmacogenetics, the book helps readers understand the implications of genetic variability on pharmacokinetics and pharmacodynamics, as well as other aspects such as adverse drug reactions. Providing coverage of specific disease areas, including cardiovascular concerns, cancer and asthma/COPD, transplantation, and pain medication, the book also looks at the clinical practices, along with the psychiatric and ethical issues that have come to dominate conversation about pharmacogenetics.

The technological applications of pharmacogenetics, including genotyping, drug disposition (metabolism and enzymes), and the impact of this research on the pharmaceutical industry and regulatory matters are all addressed in chapters by internationally recognized leaders from both academia and industry.

Including chapters on specific therapeutic areas and clinical aspects, Pharmacogenetics and Individualized Therapy helps readers, whether they're students or researchers, to understand the implications of genetic variability on pharmacokinetics and pharmacodynamics.

Autoren/Hrsg.

Maitland-Van Der Zee, Anke-Hilse

Daly, Ann K

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakotherapie, Psychopharmakotherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Preface (Dr A. H. Maitland-van der Zee and Dr A. K. Daly).

1.Pharmacogenetics: a historical perspective (Dr A. K. Daly).

Pharmacogenetics: relationship to pharmacokinetics and pharmacodynamics.

2. Pharmacogenetics in drug metabolism: Role of Phase I enzymes (Dr V. Dolzan).

3. Pharmacogenetics of phase II drug metabolizing enzymes (Prof I. Cascorbi).

4. Pharmacogenetics of drug transporters (Henriette E. Meyer zu Schwabedissne, Markus Grube, Prof. Heyo K. Kroemer).

5. Pharmacogenetics of drug targets (Dr M. Arranz and Prof A. Daly).

Pharmacogenetics in different therapeutic areas.

6. Cardiovascular Pharmacogenetics (Bas J. M. Peters, Prof. Anthonius de Boer, Prof. Tom Schalekamp, Prof. H. Klungel, Anke-Hilse Maitland-van der Zee, PharmaD PhD).

7. Pharmacogenetics in psychiatry (Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Ann K. Daly, Katherine J. Aitchison).

8. Pharmacogenetics in cancer (Dr S. Marsh).

9. Pharmacogenetics of Asthma and COPD (E. Koster, Dr G. H. Koppelman, Dr J.A. M. Raaijmakers, Dr A. H. Maitland-van der Zee).

10. Pharmacogenetics of adverse drug reactions (Prof. Ann K. Daly, Dr. Martin Armstrong and Prof. Munir Pirmohamed).

11. Pharmacogenomics of inflammatory bowel diseases (Dr. Alexander Teml, Dr. Susanne Karner, Dr. Elke Schaeffeler, Prof. Matthias Schwab).

12. Pharmacogenetics of pain medication (Dr. J. Loetsch).

Pharmacogenetics: implementation in clinical practice.

13. Ethical and social issues in pharmacogenetics testing (S. Vijverberg, Dt T. Pieters and Dr M. Cornel).

Developments in Pharmacogenetic Research.

14. High-throughput genotyping technologies for pharmacogenetics (Beatriz Sobrino and Dr. Angel Carracedo).

15. Developments in analyses in pharmacogenetic datasets (Dr A. Motsinger).

Pharmacogenetics in industry and in regulatory affairs.

16. Applications of Pharmacogenetics in Pharmaceutical Research and Development (Dr. Daniel K. Burns and Dr. Scott S. Sundseth).

17. Role of Pharmacogenetics in Registration Process (Dr. Myong-Jin Kim, Dr. Issam Zineh, Dr. Shiew-Mei Huang, and Dr. Lawrence J. Lesko).

Conclusions.

18. Pharmacogenetics: possibilities and pitfalls (Dr A. H. Maitland-van der Zee and Dr A. K. Daly).

Über Autor(innen)

Daly, Ann K
ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.

Maitland-Van Der Zee, Anke-Hilse
ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands

ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands.

ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.